A5076597967- Advanced Polymer Synthesis and Characterization
- Network Security and Intrusion Detection
- Medical Imaging and Pathology Studies
- Glaucoma and retinal disorders
- Receptor Mechanisms and Signaling
- biodegradable polymer synthesis and properties
- Ion channel regulation and function
- Wireless Communication Networks Research
- Advanced Wireless Network Optimization
- Nuclear Materials and Properties
- Nuclear and radioactivity studies
- Wireless Networks and Protocols
- Software-Defined Networks and 5G
- Retinal and Macular Surgery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mobile Ad Hoc Networks
- Intraocular Surgery and Lenses
- Engineering Applied Research
- Graphite, nuclear technology, radiation studies
- Surfactants and Colloidal Systems
- Retinal Diseases and Treatments
- Estrogen and related hormone effects
- Pickering emulsions and particle stabilization
- IPv6, Mobility, Handover, Networks, Security
- Bacterial Genetics and Biotechnology
Tokyo University of Science
2004-2024
Seirei Hamamatsu General Hospital
1994-2024
Tachikawa Hospital
2013-2024
Ludwig-Maximilians-Universität München
2024
Friedrich Baur Stiftung
2024
Kobe University
2004-2023
Toyota Motor Corporation (Japan)
2023
Fukushima Medical University
2017-2022
Southern Tohoku General Hospital
2019-2022
Tokyo Medical University Hachioji Medical Center
2022
ABSTRACT Escherichia coli mRNA interferases, such as MazF and ChpBK, are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) systems present in its genome. A homologue Staphylococcus aureus (MazF Sa ) has been shown to inhibit cell growth when induced E. . Here, we determined the cleavage site for with use of phage MS2 RNA a substrate CspA, an chaperone, which prevents formation secondary structures substrate. specifically cleaves at pentad sequence, U↓ACAU. Bioinformatics...
In this paper, we present an unobtrusive cuffless blood pressure (BP) monitoring system based on pulse arrival time (PAT) for facilitating long-term home BP monitoring. The proposed consists of electrocardiograph (ECG), a photoplethysmograph (PPG), and control circuit with Bluetooth module, all which are mounted common armchair to measure ECG PPG signals from users while sitting the in order calculate continuous PAT. Considering good linear correlation systolic (SBP) nonlinear diastolic...
Abstract The phase III double-blind PROPEL study compared the novel two-component therapy cipaglucosidase alfa + miglustat (cipa mig) with alglucosidase placebo (alg pbo) in adults late-onset Pompe disease (LOPD). This ongoing open-label extension (OLE; NCT04138277) evaluates long-term safety and efficacy of cipa mig. Outcomes include 6-min walk distance (6MWD), forced vital capacity (FVC), creatine kinase (CK) hexose tetrasaccharide (Hex4) levels, patient-reported outcomes safety. Data are...
The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis caused by antithyroid drugs are still unclear because most reports describe only a small number patients.The objective was to analyze large patients with MPO-ANCA-associated determine the time onset, drug and dose taken, symptoms, relationship between symptoms MPO-ANCA titer, incidence.We analyzed 92 in whom adverse reaction reported Chugai Pharmaceutical, company that markets...
The Mycobacterium tuberculosis genome harbors a striking number (>40) of toxin-antitoxin systems. Among them are at least seven MazF orthologs, designated MazF-mt1 through MazF-mt7, four which have been demonstrated to function as mRNA interferases that selectively target for cleavage distinct consensus sequences. As is characteristic all systems, each the mazF-mt toxin genes organized in an operon downstream putative antitoxin genes. However, only one upstream antitoxins (designated...
Four synthetic peptides (residues 20-30 and 17-34) within the growth factor-like domain (GFD) of murine human urokinase-type plasminogen activator (uPA) were examined to determine whether they inhibit production experimental spontaneous lung metastasis by Lewis carcinoma (3LL) cells. In an in vivo assay, which determines mainly later steps metastatic migration process (extravasation from bloodstream then into pulmonary tumor), none introduced i.v. single co-injection syngeneic C57B1/6 mice...
The influence of sodium dodecyl sulfate (SDS) on the shell formation hollow polymer particles prepared by SaPSeP method, which was proposed authors for preparation micrometer-sized particles, investigated. A single hole observed in seeded polymerization micrometer-sized, monodisperse divinylbenzene/p-xylene droplets aqueous medium presence SDS at concentrations above 43.3 mM, were dynamic swelling method. fraction having a and area increased with concentration.
Emulsion polymerizations of styrene using poly(oxyethylene) nonylphenyl ether nonionic emulsifier were carried out at different and initiator (potassium persulfate, KPS) concentrations to prepare polystyrene (PS) seed particles with incorporated emulsifier. Seeded emulsion the PS amounts develop a novel method for preparation multihollow particles. When small amount used, non-hollow spherical prepared. However, obtained in case large Moreover, higher concentration particles, more effectively...
The natural anticoagulant-activated protein C may inhibit inflammation and fibrosis in the lung. Platelet-derived growth factor is involved pathogenesis of lung fibrosis. This study assessed effect activated on platelet-derived expression human cell lines an vivo model Activated significantly inhibited secretion lines, primary bronchial epithelial cells, macrophages. In vitro studies also showed that endothelial receptor expressed by cells macrophages, this proteolytic activity are...
Chromophobe renal cell carcinoma (chRCC) is a tumor subtype with good prognosis, characterized by multiple chromosomal copy number variations (CNV). The World Health Organization (WHO) chRCC classification guidelines define classic and an eosinophilic variant. Large cells reticular cytoplasm prominent membranes (pale cells) are characteristic for chRCC. Classic variants were defined in 42 Swiss chRCCs, 119 Japanese chRCCs whole-slide digital images of 66 from the Cancer Genome Atlas (TCGA)...
Urinary trypsin inhibitor (UTI) inhibits efficiently tumor cell invasion and the formation of metastasis. The anti‐metastatic effect is dependent on COOH‐terminal domain II UTI [UTI‐(78−136)‐peptide]. To develop a molecule that binds with high affinity to urokinase (uPA) receptor (uPAR) surfaces, bifunctional hybrid [uPA‐(1−134)‐UTI‐(78−136)] consisting uPAR‐binding NH 2 ‐terminal fragment [UTI‐(78−136)‐peptide] uPA at ‐terminus UTI‐(78−136)‐peptide was produced in Escherichia coli by...
To study a correlation between age at the onset and myopic refraction axial length in patients with idiopathic macular hole to evaluate of size surgical outcome length.In prospective clinical study, 94 eyes 91 stage III IV were enrolled. A standardised protocol was performed using vitrectomy gas tamponade. This evaluated rate anatomical functional success surgery. assess dimensions hole, confocal laser scanning tomography employed.Age showed significant increase relation (r = 0.689, p...
To determine improved postresection survival in patients with hepatocellular carcinoma, two postoperative protocols were compared: adoptive Chemoimmunotherapy versus chemotherapy. Following resection, 24 allocated at random to receive (1) arterial infusion of Adriamycin. re-combinant interlcukin-2 and lymphokine-activated killer cells or (2) Adriamycin alone. The spleen was removed operation used prepare cells. Each group had 12 patients. They followed until signs recurrence appeared....
article Free Access Share on Optimal routing in closed queuing networks Authors: Hiroshi Kobayashi 16 Suwazaka, KDD-211, Tsurumi-ku, Yokohama 230, Japan JapanView Profile , Mario Gerla BH 3732H, Computer Science Dept., U.C.L.A., Los Angeles, CA CAView Authors Info & Claims ACM Transactions SystemsVolume 1Issue 4Nov. 1983 pp 294–310https://doi.org/10.1145/357377.357381Online:01 November 1983Publication History 35citation612DownloadsMetricsTotal Citations35Total Downloads612Last 12...
Submicrometer-sized raspberry-like polystyrene (PS) particles, which were prepared by emulsion polymerization with polyoxyethylene nonylphenyl ether nonionic emulsifier (Emulgen 910, HLB 12.2) and potassium persulfate initiator, contained 8.5 vol % (relative to the particle) of water 5.5 wt PS) Emulgen 910 in inside. The absorption decreased glass transition temperature PS particles dispersed an aqueous medium. incorporated increased increasing initial concentration polymerization, but total...
We resolved the longtime enigma in emulsion polymerization of styrene with K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>by showing fact that hollow polystyrene particles were successfully prepared by heat treatment state.
Abstract Background The functional dynamics of coagulation and fibrinolysis in patients with disseminated intravascular (DIC) vary due to the pathology severity various underlying diseases. Conventional measurements hemostasis such as thrombin–antithrombin complex, plasmin-α2-plasmin-inhibitor fibrinogen-fibrin degradation products may not always reflect critical pathophysiologic mechanisms DIC. This article aims clarify sepsis-associated DIC using assessment comprehensive fibrinolysis....