A5059378498- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Heart Rate Variability and Autonomic Control
- Motor Control and Adaptation
- Neuroendocrine regulation and behavior
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Muscle activation and electromyography studies
- Neonatal Respiratory Health Research
- Memory and Neural Mechanisms
- Mast cells and histamine
- High Altitude and Hypoxia
- Photoreceptor and optogenetics research
- Virtual Reality Applications and Impacts
- Tactile and Sensory Interactions
- Effects of Vibration on Health
- Advanced Chemical Sensor Technologies
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Adipose Tissue and Metabolism
- Hemoglobin structure and function
- Asthma and respiratory diseases
- Spinal Cord Injury Research
Showa University
2016-2025
Showa University Fujigaoka Hospital
2024
Tokyo Ariake University of Medical and Health Sciences
2014
Chiba University
2000
Ibarakihigashi National Hospital
1996
Abstract Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC that specifically chemoattracts receptor 4-positive (CCR4+) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against could inhibit induction asthmatic reaction mice elicited by OVA. was constitutively expressed lung up-regulated allergic inflammation. The specific Ab attenuated OVA-induced airway eosinophilia diminished degree...
Emotion recognition is known to change with age, but associations between the and brain atrophy are not well understood. In current study atrophied regions associated emotion were investigated in elderly younger participants. Group comparison showed no difference score, while score was years of education, age. We measured gray matter volume 18 interest including bilateral precuneus, supramarginal gyrus, orbital straight superior temporal sulcus, inferior frontal insular cortex, amygdala,...
Experiments were carried out on blindfolded human subjects to study the contribution of proprioceptive inputs from both arms in a forearm position matching task. Blindfolded accuracy was compared with when subject could see their indicator (matching) arm, they used dummy arm for matching, and looked at mirror image arm. The had been arranged so that coincided reference None these conditions significantly altered errors. When elbow flexors vibrated 70-80 Hz, illusion extension reported by...
The natural anticoagulant-activated protein C may inhibit inflammation and fibrosis in the lung. Platelet-derived growth factor is involved pathogenesis of lung fibrosis. This study assessed effect activated on platelet-derived expression human cell lines an vivo model Activated significantly inhibited secretion lines, primary bronchial epithelial cells, macrophages. In vitro studies also showed that endothelial receptor expressed by cells macrophages, this proteolytic activity are...
A growing number of brain imaging studies show functional connectivity (FC) between regions during emotional and cognitive tasks in humans. However, emotions are accompanied by changes physiological parameters such as heart rate respiration. These may affect blood oxygen level-dependent signals, well areas. This study aimed to clarify the effects noise on areas related default mode network using resting-state magnetic resonance (rs-fMRI). Healthy adult volunteers (age range: 19-51 years,...
Human bone marrow-derived mesenchymal stem/stromal cells (hMSCs) have shown potential in facilitating recovery from spinal cord injury (SCI) through communicating with microglia/macrophages (MG/MΦ). We here focused on chemokines as a candidate for the communication. Selected MG/MΦ-related were determined gene expression after SCI and further CCL2/CCR2 CCL5/CCR5 to estimate role of by hMSCs. Male C57/BL6 mice subjected transection. Gene was assayed cords following selected their receptors....
The oxygen affinity of hemoglobin is critical for gas exchange in the lung and O(2) delivery peripheral tissues. In present study, we generated model mice that carry low with Titusville mutation alpha-globin gene or Presbyterian beta-globin gene. mutant showed increased consumption CO(2) production tissue metabolism, suggesting enhanced by Hbs. histology muscle a phenotypical conversion from fast glycolytic to oxidative type. Surprisingly, spontaneously ran twice as far controls despite mild...
Abstract Electronic devices have become an indispensable part of our daily lives, while their negative aspects been reported. One disadvantage is that reading comprehension reduced when from electronic device; the cause this deficit in performance unclear. In study, we investigated for decline on a smartphone by simultaneously measuring respiration and brain activity during 34 healthy individuals. We found that, compared to paper medium, elicits fewer sighs, promotes overactivity prefrontal...
The long-term safety and utility of intravascular ultrasound (IVUS)-guided zero-contrast percutaneous coronary intervention (PCI) in patients with chronic kidney disease (CKD) are unknown.Methods Results: A total 698 consecutive treated PCI (1,061 procedures) our center were studied. Patients acute syndrome, who on maintenance hemodialysis, had a planned rotational atherectomy excluded. Finally, they divided into 2 groups: (n=55, 78 conventional (n=462, 670 procedures). After propensity...
Differences in the extent of cerebral white matter lesions (WML) and regional blood flow (rCBF) early-stage cognitive impairment (ESCI) contribute to prognosis decline; however, it is unclear precisely how WML rCBF affect decline ESCI.We examined association between WML, rCBF, ESCI, using path analysis clarify these variables each other.Eighty-three patients who consulted our memory clinic regarding loss were included this study based on Clinical Dementia Rating. Participants underwent...
We examined the effects of carotid body denervation on ventilatory responses to normoxia (21% O2 in N2 for 240 s), hypoxic hypoxia (10 and 15% 90 120 s, respectively), hyperoxic hypercapnia (5% CO2 s) spontaneously breathing urethane-anesthetized mouse. Respiratory measurements were made with a whole body, single-chamber plethysmograph before after cutting both sinus nerves. Baseline air showed that was accompanied by lower minute ventilation reduction respiratory frequency. On basis an...
Pancreatic cancer has an extremely poor prognosis, and identification of novel predictors therapeutic efficacy prognosis is urgently needed. Chemoresistance-related molecules are correlated with may be effective targets for treatment. Here, we aimed to identify chemoresistance in pancreatic cancer. We established 10 patient-derived xenograft (PDX) lines from patients performed next-generation sequencing (NGS) tumor tissues PDXs after treatment standard drugs. a gene-transferred cell line...
The aim of this study was to investigate the relationship between olfactory recognition and morphological changes in brain regions including amygdala, hippocampus, rectus, parahippocampus, orbitofrontal cortex, medial frontal cortex 27 elderly subjects younger healthy controls. specific determine which areas are associated with initial decline olfaction subjects, occurs before onset dementia. All underwent magnetic resonance imaging measure anatomical volume cortical thickness, were assessed...
Autobiographical odor memory (AM-odor) accompanied by a sense of realism specific elicits strong emotions. AM-odor differs from triggered other sensory modalities, possibly because olfaction involves unique process. Here, we examined the orbitofrontal cortex (OFC), using functional magnetic resonance imaging (fMRI) to determine which OFC subregions are related AM-odor. Both and control successively increased subjective ratings comfortableness pleasantness. Importantly, also arousal levels...
This study aimed to explore the relationship between gray matter volume changes and various clinical parameters in patients with migraine, focusing on symptom severity, quality of life, states depression anxiety. Using a case-control design, we examined 33 or without aura, 27 age-matched healthy subjects. We used magnetic resonance imaging assess volumes 140 bilateral brain regions. Clinical evaluations included Migraine Disability Assessment, Specific Quality Life Questionnaire, Center for...
Abstract Introduction Pathological abnormalities first appear in the medial temporal regions including entorhinal cortex and parahippocampus patients with Alzheimer's disease. Previous studies showed that olfactory decline elderly subjects was associated volume reductions left hippocampus without cognitive impairment. The aim of this study is to investigate link between olfaction parahippocampus, cortex, hippocampal subfields. Method 27 young controls were measured acuity, function,...