A5060624577- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Mesenchymal stem cell research
- COVID-19 and healthcare impacts
- Cardiac Valve Diseases and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiac Health and Mental Health
- Parathyroid Disorders and Treatments
- Extracellular vesicles in disease
- Peripheral Artery Disease Management
- Acute Kidney Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Synthesis of β-Lactam Compounds
- Cardiovascular Issues in Pregnancy
- Renal and Vascular Pathologies
- Cardiovascular Function and Risk Factors
Hôpitaux Universitaires de Strasbourg
2019-2024
Showa University
2016-2024
Showa University Koto Toyosu Hospital
2020-2024
Médecine Cardiovasculaire Translationnelle
2024
Koto Hospital
2020-2023
Regenerative NanoMedicine
2019-2023
Inserm
2019-2023
Kokura Memorial Hospital
2023
Toyo University
2023
Hôpital Civil, Strasbourg
2020-2021
Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators valve thrombosis. Human aortic stenosis promote activation valvular endothelial cells, leading to dysfunction, and proadhesive procoagulant responses.
Whilst the link between aging and thrombogenicity in atrial fibrillation (AF) is well established, cellular underlying mechanisms are unknown. In AF, role of senescence tissue remodeling prothrombotic state remains unclear.We investigated AF by comparing expression markers (p53 p16), with inflammatory proteins right appendages from patients sinus rhythm (SR).The 147 undergoing open-heart surgery were harvested. Twenty-one non-valvular patients, including paroxysmal (PAF) or permanent (PmAF),...
Background and Objective: Host defence mechanisms to counter virus infection include the activation of broncho-alveolar haemostasis. Fibrin degradation products secondary extravascular fibrin breakdown could contribute marked increase in D-Dimers during COVID-19. We sought examine prognostic value on lung injury non-critically ill COVID-19 patients without thrombotic events. Methods: This study retrospectively analysed hospitalized classified according a threshold following associated...
Summary Background Trichosporon asahii is the major causative agent of disseminated and deep‐seated trichosporonosis. It capable forming biofilms on surfaces, leading to medical device‐related infection. may be present as yeast form, hyphae and/or arthroconidia; however, relationship between its biofilm‐forming ability morphological transition unclear. Objectives We investigated whether T . contributes biofilm formation. also determined conditions required induce each morphologies. Methods...
While cardiovascular disease has been associated with an increased risk of coronavirus 2019 (COVID-19), no studies have described its clinical course in patients aortic stenosis who had undergone transcatheter valve replacement (TAVR). Numerous observational reported association between the A blood group and susceptibility to SARS-CoV-2 infection. Our objective was investigate frequency COVID-19 a large sample TAVR determine associations ABO occurrence outcomes. Patients 2010 were included...
The long-term safety and utility of intravascular ultrasound (IVUS)-guided zero-contrast percutaneous coronary intervention (PCI) in patients with chronic kidney disease (CKD) are unknown.Methods Results: A total 698 consecutive treated PCI (1,061 procedures) our center were studied. Patients acute syndrome, who on maintenance hemodialysis, had a planned rotational atherectomy excluded. Finally, they divided into 2 groups: (n=55, 78 conventional (n=462, 670 procedures). After propensity...
ABSTRACT Background Although cardiovascular disease has been associated with an increased risk of coronavirus 2019 (COVID-19), no studies have reported its clinical course in patients aortic stenosis who had undergone transcatheter valve replacement (TAVR). Several observational found association between the A blood group and susceptibility to SARS-CoV-2 infection, whereas O appears be protective. Objective To investigate frequency COVID-19 a large sample TAVR determine associations ABO...
Abstract This is the first study to show a stepwise increase in venous thrombotic events according COVID-19 coagulopathy (COVID-19-associated hemostatic abnormalities [CAHA]) staging and lung injuries assessed by chest computed tomography. Excess mortality and/or transfer intensive care unit CAHA staging.
Abstract Aims Recent insights have emphasized the importance of myocardial and systemic inflammation in Takotsubo syndrome (TTS). In a large registry unselected patients, we sought to evaluate whether residual high inflammatory response (RHIR) could impact cardiovascular outcome after TTS. Methods results Patients with TTS were retrospectively included between 2008 2018 three general hospitals. Three hundred eighty‐five patients split into subgroups, according tertiles C‐reactive protein...
Although there is an apparent rapid and spontaneous recovery of left ventricular ejection fraction (LVEF) in patients with Takotsubo syndrome (TTS), recent studies have demonstrated a long-lasting functional impairment those patients. The present study sought to evaluate the predictors incomplete following TTS its impact on cardiovascular mortality.
A novel and mild method was established to synthesize 6-methylidene penem compounds. This entails a MgBr(2)/Et(3)N-promoted aldol-type condensation on 6-bromopenem 12 with an appropriately substituted aldehyde yield the intermediate acetylated bromohydrin, which smoothly converted final product simultaneous deprotection of C3 carboxylic acid ester using activated zinc dust phosphate buffer at pH 6.5. process provides useful variation C-C bond formation for derivatives also serves as...
Background:Recent insights have emphasized the importance of inflammatory response in takotsubo syndrome (TTS). We sought to evaluate predictors systemic (SIRS) and its impact on cardiovascular mortality after TTS.
Bone marrow mesenchymal stem cells (BMMSCs) ameliorate tissue damage after ischemic injury. Erythropoietin (Epo) has pleiotropic effects in addition to hematopoietic activity. The aim of this study was investigate whether Epo enhanced cell survival and angiogenic effect BMMSC implantation rat limb ischemia model. MSCs were isolated from BM GFP-transgenic rats. In a culture study, promoted proliferation normoxia under the condition mimicking (1% oxygen nutrient deprivation). BMMSCs with...
Abstract Background Stroke is a major cause of disability after transcatheter aortic valve replacement (TAVR) and stroke prediction models data are crucially needed. Following TAVR, high molecular weight (HMW) multimers defect von Willebrand factor (VWF) as assessed by closure time adenosine diphosphate (CT-ADP) value > 180 seconds an independent predictor bleeding events. This study sought to identify predictors ischemic neurological events in patients who underwent TAVR the specific...
Diabetic patients often have coronary artery disease (CAD) without symptoms. It is known that females tend to silent or less chest pain and worse prognoses when they develop acute syndrome. Thus, sex differences may impact long-term outcomes in diabetes mellitus (DM) with myocardial ischemia (SMI). The present study aimed assess the influence of on DM SMI.A total 461 consecutive asymptomatic self-sufficient seen at our hospital from 2011 2017 were prospectively reviewed. Patients underwent...
Abstract Objective Trichosporon asahii is the major causative fungus of disseminated or deep-seated trichosporonosis and forms a biofilm on medical devices. Biofilm formation leads to antifungal drug resistance, so biofilm-related infections are relatively difficult treat infected devices often require surgical removal. Therefore, prevention important in clinical settings. In this study, identify metal cations that affect formation, we evaluated effects cation chelators T. . Results We...
Some asymptomatic patients with diabetes mellitus (DM) have critical coronary artery disease (CAD), although the guidelines do not recommend aggressive screening for CAD in patients. Chronic kidney (CKD) is among serious co-morbidities of severe systemic atherosclerosis. Thus, CKD may be associated potential myocardial ischaemia. Therefore, present study aimed to determine impact on incidence silent ischaemia (SMI) and long-term outcomes DM. This investigated 461 consecutive All who were...