A5086407188- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Bacterial Infections and Vaccines
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Infectious Encephalopathies and Encephalitis
- Thermal Regulation in Medicine
- Epilepsy research and treatment
- Infective Endocarditis Diagnosis and Management
- Autoimmune Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- COVID-19 and Mental Health
- Cardiac Arrest and Resuscitation
- Herpesvirus Infections and Treatments
- Pharmacological Effects and Toxicity Studies
- Pneumonia and Respiratory Infections
- Palliative Care and End-of-Life Issues
- Rabies epidemiology and control
- Infectious Diseases and Tuberculosis
- Neonatal and fetal brain pathology
- Vascular Malformations Diagnosis and Treatment
Universität Innsbruck
2016-2025
Innsbruck Medical University
2016-2025
Medical University of Vienna
1993-2023
Clinical Research Consortium
2021
The George Institute for Global Health
2015-2016
The University of Sydney
2015-2016
Hôpital Lariboisière
2015
NIHR Leicester Cardiovascular Biomedical Research Unit
2015
John Hunter Hospital
2015
University of Newcastle Australia
2015
<h3>Importance</h3> The COVID-19 pandemic continues to affect millions of people globally, with increasing reports neurological manifestations but limited data on their incidence and associations outcome. <h3>Objective</h3> To determine the phenotypes, incidence, outcomes among adults hospitalized COVID-19. <h3>Design, Setting, Participants</h3> This cohort study included patients clinically diagnosed or laboratory-confirmed at 28 centers, representing 13 countries 4 continents. was...
To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19.In this prospective, multicenter, observational cohort study we systematically evaluated signs diseases by detailed examination a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assessment), QoL (36-item Short Form), mental health (Hospital Anxiety Depression Scale, Posttraumatic Stress Disorder Checklist-5) disease...
Neurological sequelae from coronavirus disease 2019 (COVID-19) may persist after recovery acute infection. Here, the aim was to describe natural history of neurological manifestations over 1 year COVID-19.A prospective, multicentre, longitudinal cohort study in COVID-19 survivors performed. At a 3-month and 1-year follow-up, patients were assessed for impairments by examination standardized test battery including assessment hyposmia (16-item Sniffin' Sticks test), cognitive deficits...
There is a substantial amount of evidence from animal models that early brain injury (EBI) may play an important role for secondary after aneurysmal subarachnoid hemorrhage (aSAH). Cerebral microdialysis (CMD) allows online measurement metabolites, including the pro-inflammatory cytokine interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9), which indicative disruption blood-brain barrier.Twenty-six consecutive poor-grade aSAH patients with multimodal neuromonitoring were analyzed...
Background and Purpose —Intraventricular hemorrhage (IVH) remains associated with high morbidity mortality. Therapy external ventricular drainage alone has not modified outcome in these patients. Methods —Twelve pilot IVH patients who required were prospectively treated intraventricular urokinase followed by the randomized, double-blinded allocation of 8 to either treatment or placebo. Observed 30-day mortality was compared predicted obtained use a previously validated method. Results...
To determine the safety and efficacy of a novel intravascular cooling device (Cool Line catheter with Cool Gard system) to control body temperature (temperature goal <37 degrees C) in neurologic intensive care patients.A prospective, uncontrolled pilot study 51 consecutive unit at tertiary university hospital.Patients were patients an intracranial disease requiring central venous due primary (intracranial) disease. We excluded under age 19 yrs those active cardiac arrhythmia, full sepsis...
Object. Staphylococcal ventriculitis may be a complication in temporary external ventricular drains (EVDs). The limited penetration of vancomycin into the cerebrospinal fluid (CSF) is well known; pharmacodynamics and efficacy systemically compared with intraventricularly administered examined this prospective study. Methods. Ten patients whom EVDs were implanted to treat intracranial hemorrhage who suffering from drain-associated randomized two treatment groups. Five these (median age 47...
Objective: The present study was performed to test the ability of fosfomycin penetrate into CSF neurointensive care patients with ventriculostomy-associated ventriculitis.
Background and Purpose— We sought to study the effectiveness safety of endovascular cooling maintain prophylactic normothermia in comparison with standardized, stepwise, escalating fever management reduce burden patients severe cerebrovascular disease. Methods— This was a prospective, randomized, controlled trial blinded neurologic outcome evaluation between prophylactic, catheter-based (CoolGard; ie, body core temperature 36.5°C) conventional, stepwise anti-inflammatory drugs surface...
In this retrospective study, the authors analyzed frequency, anatomical distribution, and appearance of traumatic brain lesions in 42 patients a posttraumatic persistent vegetative state.Cerebral magnetic resonance (MR) imaging was used to detect number lesions, which ranged from as few five many 19, with mean 11 lesions. all cases there evidence on MR diffuse axonal injury, injury corpus callosum detected patients. The second most common area involved dorsolateral aspect rostral brainstem...
Journal Article A randomised comparison of meropenem with cefotaxime or ceftriaxone for the treatment bacterial meningitis in adults Get access E. Schmutzhard, Schmutzhard aUniversity Clinic InnsbruckAustria Search other works by this author on: Oxford Academic PubMed Google Scholar K. J. Williams, Williams bZeneca PharmaceuticalsMacclesfield, UK G. Vukmirovits, Vukmirovits cSt Laszlo Hospital Infectious DiseasesBudapest V. Chmelik, Chmelik dInfection Clinic, Ceske BudoviceCzech Republic B....
✓ Sixty consecutive patients with spontaneous subarachnoid hemorrhage (SAH) were prospectively studied by means of indirect funduscopy to address the question incidence and prognostic implications Terson's syndrome (TS) after SAH. was diagnosed in 10 (16.7%) 60 associated rebleeding seven 10. No correlation found between anatomical localization ruptured aneurysm TS laterality. Case fatality nine (90%) compared five (10%) 50 non-TS patients. It is concluded that not infrequent SAH has a poor...
Spontaneous subarachnoid hemorrhage (SAH) still has a high risk for poor outcome that is frequently attributable to symptomatic cerebral vasospasm (CVS). We hypothesize cellular microparticles (MP) play role in the pathogenesis of CVS and may serve as biomarkers CVS.In 20 consecutive SAH patients, endothelial, leukocyte, platelet, erythrocyte MP were measured during 15 days after ictus. was detected by transcranial Doppler sonography. Twenty matched volunteers served healthy...
Pressure reactivity index and oxygen are used to assess cerebral autoregulation after acute brain injury. The value of indices in the prediction delayed ischemia outcome patients with subarachnoid hemorrhage is still inconclusive. In this study, we aimed focus on predictive first 72 hours commonly referred as "early injury" comparison overall monitoring period.Retrospective observational cohort study.Neurocritical care unit at a tertiary academic medical center.Forty-three consecutive...
To assess patient characteristics associated with health-related quality of life (HR-QoL) and its mental physical subcategories 3 months after diagnosis COVID-19.
Background Neurocysticercosis (NCC), a zoonotic disease caused by the pork tapeworm T . solium , represents one of most common causes secondary epilepsy but remains often undiagnosed due to lack awareness and diagnostic facilities. Methodology We pooled data from four cross-sectional studies on NCC in eastern Africa. Study sites were Uganda, Malawi Tanzania (Dar es Salaam Haydom). The study Uganda community-based, two hospital-based. same questionnaire was used for assessment clinical...
Over a period of 22 months, 32 patients treated in three independent intensive care units the Innsbruck University Hospital were infected with extended-spectrum beta-lactamase-producing members family Enterobacteriaceae (30 Klebsiella pneumoniae isolates, 1 oxytoca isolate, and Escherichia coli isolate). As confirmed by sequencing bla gene PCR fragment, all isolates expressed SHV-5-type beta-lactamase. Genomic fingerprinting epidemic strains XbaI pulsed-field gel electrophoresis grouped 20...