Christian Ruiz

ORCID: 0000-0002-0969-7129
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About
Contact & Profiles
Research Areas
  • Cardiovascular Effects of Exercise
  • Diabetes Treatment and Management
  • Bacterial Identification and Susceptibility Testing
  • Receptor Mechanisms and Signaling
  • Cardiomyopathy and Myosin Studies
  • Pharmacological Receptor Mechanisms and Effects
  • Malaria Research and Control
  • Viral Infections and Immunology Research
  • Pharmaceutical Practices and Patient Outcomes
  • Viral Infections and Vectors
  • Neuropeptides and Animal Physiology
  • Diabetes Management and Research
  • Mosquito-borne diseases and control
  • Antimicrobial Resistance in Staphylococcus
  • Streptococcal Infections and Treatments

Novant Health
2023

Virginia Commonwealth University
2022

Cardiac troponin (cTn) T and cTnI are considered cardiac specific equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source cTnT. We aimed to confirm reliability/cardiac specificity cTnT patients with various muscle disorders (SMDs).We prospectively enrolled presenting muscular complaints (≥2 weeks) for elective evaluation 4 hospitals 2 countries. After workup, were adjudicated into 3 predefined disease categories....

10.1161/circulationaha.121.058489 article EN Circulation 2022-04-07

The μ opioid receptor (MOR) has been an intrinsic target to develop treatment of use disorders (OUD). Herein, we report our efforts on developing centrally acting MOR antagonists by structural modifications 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl) carboxamido] morphinan (NAP), a peripherally MOR-selective antagonist. An isosteric replacement concept was applied and incorporated with physiochemical property predictions in the molecular design. Three analogs, namely, 25,...

10.1021/acs.jmedchem.2c00087 article EN Journal of Medicinal Chemistry 2022-03-08

Background: Eastern equine encephalitis virus (EEEV) is a rare mosquito-borne illness exhibiting rapid neurological deterioration and permanent damage. Despite its >30% mortality >60% long-term damage, EEEV has no approved antiviral medication or vaccination. This report uniquely aims to describe case of provide current literature review therapeutic preventative options from the clinical perspective guide clinicians public health workers, along with informing them about impact knowledge...

10.1089/vbz.2023.0011 article EN Vector-Borne and Zoonotic Diseases 2023-10-23

The modified Dundee classification has recently been validated in various studies for nonpurulent skin and soft tissue infections. This yet to be applied the United States within community hospital settings optimize antimicrobial stewardship ultimately patient care.A retrospective, descriptive analysis was performed of 120 adult patients admitted St. Joseph's/Candler Health System infections between January 2020 September 2021. Patients were classified into their classes, frequencies...

10.1093/ofid/ofad186 article EN cc-by-nc-nd Open Forum Infectious Diseases 2023-04-06
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