A5051448781- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Biomedical Text Mining and Ontologies
- Software Engineering Research
- Logic, programming, and type systems
- Formal Methods in Verification
- Software Testing and Debugging Techniques
- Data-Driven Disease Surveillance
- Diphtheria, Corynebacterium, and Tetanus
- Vaccine Coverage and Hesitancy
- Pharmacovigilance and Adverse Drug Reactions
- Advanced Malware Detection Techniques
- Security and Verification in Computing
- Misinformation and Its Impacts
- Pharmacogenetics and Drug Metabolism
- Infectious Diseases and Mycology
- Respiratory viral infections research
- Historical Medical Research and Treatments
- Computational Drug Discovery Methods
- Pharmaceutical Quality and Counterfeiting
- Machine Learning in Bioinformatics
- Pharmaceutical studies and practices
- Cerebrovascular and genetic disorders
- Healthcare Policy and Management
Technical University of Munich
2022-2024
Klinikum rechts der Isar
2024
Université Paris-Saclay
2020-2022
Centre National de la Recherche Scientifique
2020-2022
Erasmus MC
2015-2022
Numerical Method (China)
2019-2021
Université Paris-Sud
2020
Laboratoire de Recherche en Informatique
2020
University Medical Center
2016
University Hospital and Clinics
2016
Abstract 5q-associated spinal muscular atrophy is a rare neuromuscular disorder with the leading symptom of proximal muscle weakness. Three different drugs have been approved by European Medicines Agency and Food Drug Administration for treatment patients, however, long-term experience still scarce. In contrast to clinical trial data restricted patient populations short observation periods, we report here real-world evidence on broad spectrum patients early-onset treated nusinersen focusing...
There is growing interest in whether social media can capture patient-generated information relevant for medicines safety surveillance that cannot be found traditional sources. The aim of this study was to evaluate the potential contribution mining networks using following associations as case studies: (1) rosiglitazone and cardiovascular events (i.e. stroke myocardial infarction); (2) human papilloma virus (HPV) vaccine infertility. We collected publicly accessible, English-language posts...
Abstract Background The development and approval of disease modifying treatments have dramatically changed progression in patients with spinal muscular atrophy (SMA). Nusinersen was approved Europe 2017 for the treatment SMA irrespective age severity. Most data on therapeutic efficacy are available infantile-onset SMA. For type 2 3, there is still a lack sufficient evidence long-term experience nusinersen treatment. Here, we report from SMArtCARE registry non-ambulant children typen 3 under...
We describe our approach to the chemical–disease relation (CDR) task in BioCreative V challenge. The CDR consists of two subtasks: automatic disease-named entity recognition and normalization (DNER), extraction chemical-induced diseases (CIDs) from Medline abstracts. For DNER subtask, we used concept tool Peregrine, combination with several optimization steps. CID system, which named RELigator, was trained on a rich feature set, comprising features derived graph database containing prior...
Background and objectives: Disease progression in patients with spinal muscular atrophy (SMA) has changed dramatically within the past years due to approval of three different disease-modifying treatments. Nusinersen was first drug be approved for treatment SMA patients. Clinical trials provided data from infants type 1 children 2, but there is still insufficient evidence only scarcely reported long-term experience nusinersen ambulant Here, we report SMArtCARE registry under a follow-up...
We describe the development of a chemical entity recognition system and its application in CHEMDNER-patent track BioCreative 2015. This community challenge includes Chemical Entity Mention Patents (CEMP) task Passage Detection (CPD) classification task. addressed both tasks by an ensemble that combines dictionary-based approach with statistical one. For this purpose performance several lexical resources was assessed using Peregrine, our open-source indexing engine. combined results on patent...
Abstract Background Assessment of drug and vaccine effects by combining information from different healthcare databases in the European Union requires extensive efforts harmonization codes as vocabularies are being used across countries. In this paper, we present a web application called CodeMapper, which assists mapping case definitions to vocabularies, while keeping transparent record complete process. Methods CodeMapper builds upon coding contained Metathesaurus Unified Medical Language...
The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test system for rapid benefit-risk (B/R) monitoring vaccines using European healthcare databases. Event misclassification can result biased estimates. Using different algorithms identifying cases Bordetella pertussis (BorPer) infection as case, we aimed describe strategy quantify event misclassification, when manual chart review not feasible. Four...
Postmarketing drug safety surveillance relies upon measures of disproportionate reporting in spontaneous systems. It has been hypothesized that products or events reported frequently may "mask" signals.We analyzed the masking effect vaccines pediatrics EudraVigilance database by conducting disproportionality analysis full (containing vaccine exposures) and a restricted set (excluding exposures). We measured performance odds ratio (ROR) both data sets using pediatric-specific reference...
Identifying the cause of a proof failure during deductive verification programs is hard: it may be due to an incorrectness in program, incompleteness program annotations, or prover. The changes needed resolve depend on its category, but prover cannot provide any help categorisation. When using SMT solver discharge obligation, that can propose model from failed attempt, which possible counterexample derived. But invalid, case add more confusion than help. To check validity and categorise...
Background Multiple sclerosis (MS) shares clinical/radiological features with several monogenic diseases that can mimic MS. Objective We aimed to determine if exome sequencing identify in patients diagnosed MS according the McDonald criteria thus uncovering them as being misdiagnosed. Methods performed whole a cohort of 278 MS, clinically or radiologically isolated syndrome without cerebrospinal fluid-specific oligoclonal bands (CSF-OCBs) (n = 228), positive family history 44), both 6),...
The Eighth International Congress of Hygiene and Demography, held at Buda-Pesth September 2 to 8, 1894, can be considered as one the most remarkable important reunions representatives medical sciences from all countries during latest times. This judged reports so far published. One proceedings was discussion on etiology prophylaxis diphtheria, which may shortly related in following: Löffler, Greifswald Germany, says that diphtheria is produced by a specific bacillus, whose importance not...
<h3>Report of 121 Cases Diphtheria Treated at the City Hospital, Urban, by W. Koerte.</h3> —The first injections serum were made in January, 1894, and continued without interruption all children with diphtheria until end March. In consequence a want specific treatment was suspended June, when it recommenced July 21. Then second interval came, middle September, from which time third series factories Hochst-am-Main followed. The treatment, besides use serum, merely symptomatic. cases diagnosis...
ZUSAMMENFASSUNG Die 5q-assoziierte spinale Muskelatrophie (SMA) ist eine autosomal-rezessiv vererbte Erkrankung, die durch biallelische Defekte im SMN1-Gen (survival of motor neuron 1) auf Chromosom 5q verursacht wird. Der Gendefekt bewirkt einen fortschreitenden Untergang motorischer Vorderhornzellen Rückenmark, was zu progredienten atrophen Paresen führt. Manifestationsalter und Schweregrad können sehr unterschiedlich sein. Anzahl der SMN2-Genkopien entscheidende Modifier, es werden jedoch...
Vaccine information in European electronic health record (EHR) databases is represented using various clinical and database-specific coding systems drug vocabularies. The lack of harmonization constitutes a challenge reusing EHR data collaborative benefit-risk studies about vaccines. We designed an ontology the properties that are commonly used vaccine descriptions, called Ontology Descriptions (VaccO), with dictionary for analysis multilingual descriptions. implemented five algorithms...