A5020089586- Coffee research and impacts
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Physical Education and Gymnastics
- Sports Performance and Training
- Healthcare Regulation
- Natural Antidiabetic Agents Studies
- Physical Education and Sports Studies
- Exercise and Physiological Responses
- Phytochemistry Medicinal Plant Applications
- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Youth, Drugs, and Violence
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- Neuroendocrine regulation and behavior
- Urinary Bladder and Prostate Research
- Body Composition Measurement Techniques
- Blood Pressure and Hypertension Studies
- Agricultural and Food Sciences
- Brazilian Legal Issues
- Occupational Health and Burnout
Universidade Federal de Juiz de Fora
2025
Faculdade Guairacá
2017-2024
ORCID
2024
National Institute for Space Research
2024
Universidade Estadual do Centro-Oeste
2013-2023
Universidade de São Paulo
2020-2023
Universidade Federal do Paraná
2017-2021
Abcam (United States)
2021
Pontifícia Universidade Católica de Minas Gerais
2020
Faculdade de Medicina do ABC
2013-2020
<h3>Objective</h3> To evaluate whether eculizumab helps patients with anti–acetylcholine receptor–positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status minimal manifestations (MM), we assessed patients9 throughout REGAIN (Safety and Efficacy Eculizumab in AChR+ Refractory Generalized Gravis) its open-label extension. <h3>Methods</h3> Patients who completed randomized controlled trial continued into...
To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using Quality Life Neurological Disorders (Neuro-QOL) Fatigue subscale, and to correlations between improvements Neuro-QOL other clinical endpoints.Neuro-QOL Fatigue, MG Activities Daily Living (MG-ADL), Quantitative (QMG), 15-item (MG-QOL15) scales were administered during phase 3, randomized, placebo-controlled REGAIN study...
This study investigates how expanding transit catchment areas through new stations openings affects ridership and bilateral trip flows. Using the expansion of rapid network in São Paulo Metropolitan Region (SPMR) over a 10-year period, we combine household travel survey data with spatially detailed information econometric models to estimate changes behavior conditions. Our findings reveal that increases population within rail station positively influence flows, whereas BRT has no effect on...
Aims: This study aimed to evaluate the effects of Baccharis dracunculifolia extract on glycemic regulation, lipid profile, and metabolic parameters in diabetic rats, as well its potential a complementary therapeutic intervention for diabetes management. Study Design: Experimental using controlled animal model diabetes. Place Duration Study: The was conducted at UNICENTRO between 2017 2018. Methodology: Fifty-six male Wistar rats (120 days old) were divided into eight groups: Tween Control...
Background: In the phase III eculizumab for refractory generalized myasthenia gravis REGAIN study [ClinicalTrials.gov identifier: NCT01997229] and its open-label extension (OLE) NCT02301624], patients with treatment-refractory antiacetylcholine receptor antibody-positive had clinically meaningful improvements versus placebo. This subgroup analysis evaluated data from a recent history of chronic intravenous immunoglobulin (IVIg) use before entry. Methods: The comprised who received IVIg at...
The viewpoint and reaction of a country towards climate change are shaped by its political, cultural, scientific backgrounds, in addition to the distinct characteristics evolving anticipated actual consequences phenomenon times ahead. A region’s has significant impact on how water is managed used, mostly primary sector, both distribution ecosystem types amount spreading species Earth. As result, environment agricultural practices affected climate, so evaluating evolution extremely pertinent....
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of open-label extension (NCT02301624), eculizumab's efficacy and safety were assessed 11 Japanese 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized gravis. For who had received placebo during REGAIN, treatment resulted...
Studies evaluating the toxicity caused by fungal exopolysaccharides of β-(1-->6)-D-glucan type are rare. In this study, toxicological effects sub-chronic treatments with lasiodiplodan (β-(1-->6)-D-glucan from Lasiodiplodia theobromae MMPI) were evaluated in mice through assessment biochemical, hematological, and histopathological alterations. Thirty-two (16 male, 16 female) used study divided two groups; one group received (50 mg/kg body weight) daily for 28 days via gavage, another (control...
Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of Baccharis genus that are specifically distributed Americas.This study evaluated effects methanol extracts from dracunculifolia DC. Asteraceae on metabolic parameters, satiety, growth monosodium glutamate (MSG) induced-obesity model rats.MSG was administered to 32 newborn rats (4 mg/g body weight) once daily 5...
The essential hypertension has been associated with membrane cell damage. aim of the present study is investigate relationship between erythrocyte Na(+),K(+)-ATPase and lipoperoxidation in prehypertensive patients compared to normotensive status. involved (systolic: 136 ± 7 mmHg; diastolic: 86.8 6.3 n = 8) healthy men normal blood pressure 110 6.4 76.1 4.2 who were matched for age (35 4 years old). venous samples antecubital vein (5 mL) collected into a tube containing sodium heparin as...
Urinary bladder dysfunction affects several people worldwide and shows higher prevalence in women. Micturition is dependent on the Barrington´s nucleus, pontine urine storage center periaqueductal gray matter, but other brain stem areas are involved regulation. Neurons medulla oblongata send projections to hypothalamic nuclei as supraoptic which synthetizes oxytocin its turn, this peptide released circulation. We investigated effects of intravenous injection (OT) urinary sham ovariectomized...
The study investigated the effect of supplementation with maltodextrin (CHO) alone or associated to caffeine during exercise in T2DM subjects.
Context: Chronic stress results from repeated exposure to one or more types of stressors over a period, ranging days months, and can be associated with physical, behavioral, neuropsychiatric manifestations. Some physiological alterations resulting chronic potentially cause deficits on spatial learning memory.Objective: This study investigated the effects variable (CVS) administration l-arginine creatine memory in rats. Furthermore, body, heart, adrenal weight, plasma glucose corticosterone...
Lasiodiplodan, an exocellular (1→6)-β-d-glucan of molecular weight >1.4 × 106 Da produced by MMPI strain Lasiodiplodia theobromae (Pat.) Griffon & Maubl. (Brotyosphaeriaceae) is known to exhibit anti-proliferative activity on breast cancer cells (MCF-7), anticoagulant when sulfonylated, and reduction in transaminase administered rats.The effect intracerebroventricular (I.C.V) injection lasiodiplodan neurotoxicity behavioural changes induced d-penicillamine was investigated.Twenty-four male...
The development of obesity and prediabetes under conditions long-term consumption fructose solution in ratsVictoria Konopelnyuk, Alona Yurchenko, Taras Karpovets, Ludmila Ostapchenko
Recently, the Brazilian Electricity Regulatory Agency (ANEEL) regularized electricity prepayment system and opened a general discussion about technologies, resources, implementations for metering system. In several countries, consumer charges value equivalent to kilowatt-hours that he wishes buy use. However, some consumers purchase credit with expectation charge remains specific time, but they may be surprised end before expected time. For this reason, paper proposes automatic consumption...
OBJETIVO: O presente estudo verificou os efeitos da suplementação com cafeína associada ao exercício físico agudo sobre a resposta glicêmica em ratos diabéticos. MÉTODOS: Foram utilizados 32 animais, 60 dias de idade, e 238±3 g peso, divididos quatro grupos: controle, controle cafeína, diabetes diabetes/cafeína. modelo foi induzido pela administração intraperitoneal mg/kg estreptozotocina. De forma aguda, animais receberam 6 mg ou salina para grupos-controles minutos antes do físico. Os...
Objective: This study investigated the chronic (oral) and acute (hypothalamic infusion) effects of L-arginine supplementation on feed intake, body composition, behavioral changes in rats. Methods: Twenty rats were divided into two groups treated orally for 60 days; one group received (1 g/kg weight) saline mL/NaCl 0.9%). Daily consumption water food evaluated, weight monitored. After oral treatment, underwent stereotactic biopsy a was injected with 2 µL (0.5 mM) another an injection (0.9%...
RESUMO Introdução: A cafeína é atualmente a substância mais consumida no mundo, e associada ao exercício físico, vem trazendo importantes ganhos desempenho. Objetivo: Investigar efeitos bioquímicos da suple-mentação aguda de após um endurance em ratos Wistar. Métodos: Foram utilizados 27 Wistar machos, pesando 357 ± 73 g, distribuídos forma aleatória três grupos: 1) Controle (sem suplementação exercício); 2) Salina (salina + 3) Cafeína (6 mg/Kg exercício). As suple-mentações foram...