A5055410678- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Liver Disease Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Neuroendocrine regulation and behavior
- Adolescent Sexual and Reproductive Health
- Urinary Bladder and Prostate Research
- COVID-19 diagnosis using AI
- Glycogen Storage Diseases and Myoclonus
- Neuroblastoma Research and Treatments
- Ovarian function and disorders
- HIV/AIDS Impact and Responses
- Pituitary Gland Disorders and Treatments
- Blood donation and transfusion practices
- Digital Imaging for Blood Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Respiratory viral infections research
- Reproductive tract infections research
- Asthma and respiratory diseases
- Sex work and related issues
- Biochemical and Molecular Research
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2025
Irmandade da Santa Casa de Misericórdia de São Paulo
2024
Faculdade de Medicina do ABC
2012-2023
Instituto Adolfo Lutz
2022
Universidade Federal de São Paulo
2021
Instituto de Saúde
2020
Fundação Oswaldo Cruz
2005-2010
Abstract Cytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), production abnormal cytokine levels appears to contribute progression disease, viral persistence, and affects response therapy. Cytokine genes are polymorphic at specific sites, certain polymorphisms located within coding/regulatory regions have been shown affect overall expression secretion cytokines. The aim present study was identify potential markers cytokines associated with...
ABSTRACT Introduction Recombinant human growth hormone (GH) therapy shows variable responses in patients with deficiency (GHD), highlighting the need for reliable biomarkers to predict individual sensitivity. Objective This study investigated circulating microRNAs (miRNAs) involved plate regulation during GH prepubertal children GHD, aiming establish a miRNA panel correlating responsiveness. Patients and Methods Sixteen were treated daily recombinant (0.033 mg/kg) 6 months. Two participants...
Hepatitis C virus (HCV) infection has been identified as the major cause of chronic liver disease among patients on hemodialysis (HD), despite important reduction in risks obtained by testing candidate blood donors for anti-HCV antibodies and use recombinant erythropoietin to treat anemia. A cross-sectional study was performed estimate prevalence HCV genotypes HD Salvador, Northeastern Brazil. Anti-HCV seroprevalence determined ELISA 1243 from all ten different dialysis centers city....
Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IDUs), with seroprevalence ranging from 50-90%. In this paper, serological and virological parameters were investigated 194 IDUs, 94 ex-IDUs 95 non-IDUs that sampled by "snowball" technique in three localities renowned for both intense use trafficking activities Salvador, Brazil. The majority of participants male, but sex mean age differed significantly between IDUs/ex-IDUs (p < 0.05). Anti-HCV...
To evaluate the prevalence of Mycoplasma hominis, genitalium, Ureaplasma urealyticum, Chlamydia trachomatis, Trichomonas vaginalis and Neisseria gonorrhoeae in women with no gynecologic complaints screened Human Reproduction outpatient clinic Faculdade de Medicina ABC, Brazil.A total 106 without reproductive age were evaluated. DNA was extracted from cells genitourinary tract bacteria for detection six types by polymerase chain reaction.We found that 11.3 % had infection M. hominis 2.83 C....
The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in State Bahia. Anti-HCV investigated by ELISA a cohort 268 A/B who were followed-up reference unit for hemotherapy viremia genotypes also determined subset 66 anti-HCV seropositive hemophiliacs. Seroprevalence among 42.2% (95% CI 36.5-48.1) significantly higher (p<0.05) according age > or =10 years, presence factor VIII/IX inhibitory antibodies other infection markers. None less...
Urinary bladder dysfunction affects several people worldwide and shows higher prevalence in women. Micturition is dependent on the Barrington´s nucleus, pontine urine storage center periaqueductal gray matter, but other brain stem areas are involved regulation. Neurons medulla oblongata send projections to hypothalamic nuclei as supraoptic which synthetizes oxytocin its turn, this peptide released circulation. We investigated effects of intravenous injection (OT) urinary sham ovariectomized...
We determined the frequency of hepatitis C virus (HCV) genotypes in anti-HCV seropositive patients state Alagoas, Brazil, by means nested-reverse transcription-polymerase chain reaction (RT-nested-PCR) followed restriction fragment length polymorphism (RFLP) amplified fragments 5´NCR. The nested-PCR with genotype-specific primers from core region was carried out when detection not possible first approach. Detectable HCV-RNA present 115 (74.7%) 154 serum samples. Genotype 1 most frequent...
HCV infected patients frequently ask their physician about the risk of transmission to partners. Although it is easy answer that does exist, difficult quantify. We studied infection in stable heterosexual couples: anti-HCV positive hemodialytic therapy and Thirty-four couples were tested by third generation ELISA RIBA. Blood samples evaluated RT-PCR detected sequences genotyped restriction fragment length polymorphism. Concordance was observed only one couple which both subjects dialytic...
Background: The disease caused by hepatitis C virus (HCV) is asymptomatic, silent, and progressive liver disease. In HCV-infected patients the increase in serum HA associated with development of hepatic fibrosis progression. Methods: HCV-RNA detection was performed all serological samples blood donors that tested positive using HCV Ultra ELISA. Determination hyaluronan (HA) ELISA-like fluorometric method. content compared to viral load, genotype virus, as well ALT GGT biomarkers. Results:...
The purpose of this prospective non-randomized study was to the effectiveness semen washing followed by intrauterine insemination (IUI) in Human Immune Deficiency Virus (HIV)-discordant couples which male partner infected, preventing HIV transmission uninfected and offspring. performed a private assisted reproductive center specialized with infectious diseases enrolled sixty-nine fertile tested positive for HIV, seeking treatment. Triple sperm viral RNA purification real-time polymerase...
McArdle disease presents clinical and genetic heterogeneity. There is no obvious association between genotype phenotype. PYGM (muscle glycogen phosphorylase gene) mRNA expression its with clinical, morphological, aspects of the as a set have not been studied previously.We investigated variation in considering number PTCs (premature termination codon) per sample compared skeletal muscle samples from 15 patients 16 controls to different disease.The main variant found was c.148C>T...
Ectopic posterior pituitary (EPP) is a rare congenital abnormality, sometimes associated with other midline defects, such as stalk interruption syndrome (PSIS), in which thin or absent and anterior hypoplasia are combined to EPP. Most cases sporadic, few reports of familial cases, many hypopituitarism (CH) remain unsolved.
The Santo André Regional Center from Adolfo Lutz Institute evaluated 91 537 samples by reverse transcription-polymerase chain reaction (RT-PCR) to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) March 2020 April 2021. age, sex, and race of patients three cities in southeastern Brazil, namely São Bernardo do Campo (SBC), Diadema, Mauá were assessed association the rate positive results using generalized linear models. Circulating lineages obtained GISAID intralineage...