A5102900549- Proteoglycans and glycosaminoglycans research
- Obesity, Physical Activity, Diet
- Glycosylation and Glycoproteins Research
- Nutritional Studies and Diet
- Fibroblast Growth Factor Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Youth, Drugs, and Violence
- Cognitive Abilities and Testing
- Protease and Inhibitor Mechanisms
- Aquaculture Nutrition and Growth
- Liver Disease Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Consumer Attitudes and Food Labeling
- Urinary Bladder and Prostate Research
- Infant Development and Preterm Care
- Glaucoma and retinal disorders
- Abdominal Trauma and Injuries
- Thyroid and Parathyroid Surgery
- Education, Achievement, and Giftedness
- Cardiac Fibrosis and Remodeling
- Agricultural and Food Sciences
- Dupuytren's Contracture and Treatments
Universidade Federal de São Paulo
2009-2024
Universidad Internacional
2021
National Council for Scientific and Technological Development
2021
Gavekal Intelligence Software (France)
2017
Inserm
2017
Centro San Giovanni di Dio Fatebenefratelli
2017
Centre National de la Recherche Scientifique
2017
AXA Research Fund
2017
Istituti di Ricovero e Cura a Carattere Scientifico
2017
Sorbonne Université
2017
Shrimp head waste is a major byproduct of crustacean processing in North-eastern Brazil and represents an interesting source bioactive molecules. Additionally, its use increases the sustainability fishery products. The present study reports process developed for recovering molecules from shrimp heads through autolysis. A protein hydrolysate (120 ± 0.4 g) formed by 9% (w/v) solution was recovered lyophilized 1 kg heads. Approximately 195 0.5 mg carotenoids as ethanolic extract. recovery...
The year 2007 was marked by widespread adverse clinical responses to heparin use, leading a global recall of potentially affected batches in 2008. Several analytical methods have since been developed detect impurities preparations; however, many are costly and dependent on instrumentation with only limited accessibility. A method based simple UV-scanning assay, combined principal component analysis (PCA), impurities, such as glycosaminoglycans, other complex polysaccharides aromatic...
Hyaluronan (HA) shows promise for detecting cancerous change in pleural effusion and urine. However, there is uncertainty about the localization of HA tumor tissue its relationship with different histological types other components extracellular matrix, such as angiogenesis. We evaluated association between degree malignancy through expression lung sputum. Tumoral had significantly increased compared to normal tissue. Strong staining intensity associated cancer cells was significant squamous...
Calcitonin (CT) is a sensitive marker of medullary thyroid carcinoma (MTC) and used for primary diagnosis follow-up after thyroidectomy. However, persistently elevated CT observed even complete surgical removal without evidence recurrent or persistent tumor.To investigate the presence assay interference in serum MTC patients who are apparently structural disease.We studied three index cases 14 with metastatic MTC. The level was measured using an immunofluorometric assay. Screening performed...
Summary objective Immunosuppressive treatment of Graves’ opthalmopathy (GO) should be restricted to patients with active eye disease, but assessing disease activity is difficult. Several methods evaluate GO have been introduced, none them satisfactory. Glycosaminoglycans (GAGs) are complex polysaccharides that participate on the pathogenesis and attempts correlate its local increase urinary GAGs (uGAGs) or serum hyaluronan (sHA) made, available techniques labourious, time‐consuming difficult...
Various branded low molecular weight heparins (LMWHs) have been used for the treatment and prevention of thrombotic over 20 years. With introduction generic LMWHs recent events involving heparin contamination, a great deal effort is being expended in investigating ways monitoring regulating this class complex drugs. In paper, we present characterization different forms LMWHs, as well comparison 5 enoxaparin copies from manufactures. The data suggests that, while some these drugs are...
Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim present study was to investigate alterations in extracellular matrix disease. used tissues collected surgical procedure from individuals that presented a well-established disease, while control samples were obtained biopsies fresh cadavers. Immunohistochemistry analysis followed digital quantification performed evaluate TGF-β, heparanases...
Objective To compare and evaluate concentrations of hyaluronic acid (HA) in normal vocal folds both young elderly people sexes. Study Design Experimental study. Setting The research was carried out at the ENT, Head Neck Surgery Department Pharmacology Institute São Paulo Federal University. Subjects Methods Enzyme‐linked immunosorbent assay plates coated with biotin‐conjugated binding protein streptavidin‐europium conjugate were sequentially incubated samples from middle portion cover,...
Background. Cardiac remodeling is ultimately regulated by components of the extracellular matrix (ECM). We investigated important role that growth factors play in regulation ECM occurs as a consequence myocardium damage.
Dupuytren's disease (DD) is a prevalent fibroproliferative disorder of the hand, shaped by genetic, epigenetic, and environmental influences. The extracellular matrix (ECM) complex assembly diverse macromolecules. Alterations in ECM's content, structure organization can impact both normal physiological functions pathological conditions. This study explored content glycosaminoglycans, proteoglycans, collagen ECM patients at various stages DD, assessing their potential as prognostic...
Purpose: The present study evaluates chondroitin sulfate (CS) and heparan (HS) in the urine hyaluronic acid (HA) plasma of patients with prostate cancer before after treatment compared to a control group. Materials Methods: Plasma samples were used for HA dosage quantification CS HS from forty-four fourteen controls. Clinical, laboratory radiological information correlated glycosaminoglycan by statistical analysis. Results: Serum was significantly increased (39.68 ± 30.00 ng/ mL) group...
Objective To investigate the relationship between macronutrient intake adequacy and national diet quality index score. Methods The study analyzed a representative sample of 1,662 individuals from municipality São Paulo who participated in cross-sectional called Health Survey-Capital (2008/2009). Two 24-hour recalls were collected. Habitual was determined by Multiple Source Method. Brazilian calculated as suggested, given World Organization Food Agriculture recommendations. A generalized...
Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about safety of heparin, since in 2008, adverse effects associated with presence oversulfated chondroitin sulfate (OSCS) were observed preparations which led to death patients, causing a global public health crisis. However, it not clarified whether OSCS added preparation, or already introduced during production raw heparin. Using combination different...
This study characterized heparin isolated from tuna skins. Glycosaminoglycans were skin after digestion using anion exchange resin. Heparin was eluted the resin by sodium chloride gradient and further fractionated acetone fractionation. Anticoagulant activity determined activated partial thromboplastin time Heptest assays. Potency amidolytic antifactor IIa Xa The presence of in extracted glycosaminoglycans confirmed (13)C-nuclear magnetic resonance. clotting times doubled at concentrations...
Metastasis is responsible for the majority of deaths among patients with malignant melanoma. Despite recent advances, current and modern therapies are ineffective and/or financially unfeasible. Thus, in this study, we investigated two low‑cost highly‑diluted natural complexes (HDNCs) that have been shown to be effective against melanoma a murine model vivo. The aim study was determine mechanisms through which these HDNCs directly affect cells, either alone or an artificial tumor...
Background: The disease caused by hepatitis C virus (HCV) is asymptomatic, silent, and progressive liver disease. In HCV-infected patients the increase in serum HA associated with development of hepatic fibrosis progression. Methods: HCV-RNA detection was performed all serological samples blood donors that tested positive using HCV Ultra ELISA. Determination hyaluronan (HA) ELISA-like fluorometric method. content compared to viral load, genotype virus, as well ALT GGT biomarkers. Results:...
OBJETIVO: Avaliar a densidade energética da dieta de adultos do município São Paulo e fatores associados. SUJEITOS E MÉTODOS: Participantes estudo ISA-Capital, com amostragem probabilística (n = 710 adultos). O consumo alimentar foi avaliado pelo R24h. As correlações foram investigadas coeficiente correlação Pearson. associações dados demográficos, socioeconômicos estilo vida por modelos regressão multivariados. RESULTADOS: A média 1,98 kcal/g (IC95% [1,94; 2,01]) correlacionou-se...
INTRODUÇÃO: A fibromatose gengival hereditária (FGH) é uma condição rara, considerada desordem genética e/ou de desenvolvimento, não induzida por biofilme. Clinicamente manifesta-se pelo aumento progressivo e benigno dos tecidos gengivais, que podem cobrir total ou parcialmente os dentes. Etiologicamente, possui origem genética, sendo transmitida predominantemente forma autossômica dominante. OBJETIVO: O objetivo deste artigo apresentar técnicas cirúrgicas para a remoção do excesso tecido...