A5057104106- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Laser Applications in Dentistry and Medicine
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Exercise and Physiological Responses
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Disease and Adiposity
- Mesenchymal stem cell research
- Cardiac pacing and defibrillation studies
- Electrospun Nanofibers in Biomedical Applications
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Cardiac Arrhythmias and Treatments
- Eicosanoids and Hypertension Pharmacology
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Peptidase Inhibition and Analysis
Universidade Federal de São Paulo
2015-2024
Fundação de Apoio à Universidade Federal de São Paulo
2004-2017
Universidade Nove de Julho
2014-2016
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016
Universidade Federal do Espírito Santo
2013
Hy-Line (United States)
2007
Universidade Estadual Paulista (Unesp)
1984-2006
Universidade de São Paulo
1992
Background— The present study addresses the hypothesis that activity of dipeptidyl peptidase IV (DPPIV), an enzyme inactivates peptides possess cardioprotective actions, correlates with adverse outcomes in heart failure (HF). therapeutic potential DPPIV inhibition preventing cardiac dysfunction is also investigated. Methods and Results— Measurements blood samples obtained from 190 patients HF 42 controls demonstrated exhibited increase ≈130% circulating compared healthy subjects....
SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless presence or absence diabetes, but mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested hypothesis that inhibitor empagliflozin (EMPA) inhibits proximal tubule (PT) NHE3 activity improves renal salt water handling.Male Wistar were subjected to myocardial infarction sham operation. After 4 weeks, developed treated EMPA untreated for an additional weeks....
Mechanisms underlying inotropic failure in septic shock are incompletely understood. We previously identified the presence of exosomes plasma patients. These released mainly by platelets, produce superoxide, and induce apoptosis vascular cells a redox-dependent pathway. hypothesized that circulating platelet-derived could contribute to dysfunction sepsis. collected blood samples from 55 patients with 12 healthy volunteers for exosome separation. Exosomes individuals were investigated...
Background Cardiac cell transplantation is compromised by low retention and poor graft viability. Here, the effects of co-injecting adipose tissue-derived stem cells (ASCs) with biopolymers on cardiac retention, ventricular morphometry performance were evaluated in a rat model myocardial infarction (MI). Methodology/Principal Findings 99mTc-labeled ASCs (1×106 cells) isolated from isogenic Lewis rats injected 24 hours post-MI using fibrin a, collagen (ASC/C), or culture medium (ASC/M) as...
Myocardial infarction (MI) is accompanied by cardiac growth, increased collagen deposition, cell death and new vascularization of the tissue, which results in reduced ventricular compliance. The MiRNA-29 family (29a, 29b, 29c) targets mRNAs that encode collagens other proteins involved fibrosis. In this study we assessed effects swimming training (ST) on expression miRNA-29 genes encoding after MI rats.ST consisted 60 min/day/10 weeks began four MI. MiRNA analysis were performed infarcted...
Cell therapy approaches for biologic cardiac repair hold great promises, although basic fundamental issues remain poorly understood. In the present study we examined effects of timing and routes administration bone marrow cells (BMC) post-myocardial infarction (MI) efficacy an injectable biopolymer scaffold to improve cell retention function.(99m)Tc-labeled BMC (6 x 10(6) cells) were injected by 4 different in adult rats: intravenous (IV), left ventricular cavity (LV), with temporal aorta...
Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the size, and evaluate anatomic functional variables of left ventricle. Myocardial infarction produced 43 female Wistar rats by ligature coronary artery. Echocardiography performed 5 weeks later measure ventricular diameter transverse area (mean 3 planes), size (percentage arc with on systolic function change fractional area,...
Heart failure (HF) is associated with a reduced effective circulating volume that drives sodium and water retention extracellular expansion. We therefore hypothesized Na + /H exchanger isoform 3 (NHE3), the major apical transcellular pathway for reabsorption in proximal tubule, upregulated an experimental model of HF. HF was induced male rats by left ventricle radiofrequency ablation. Sham-operated (sham) were used as controls. At 6 wk after surgery, exhibited cardiac dysfunction dramatic...
Myocardial hypertrophy and dysfunction occur in response to excessive catecholaminergic drive. Adverse cardiac remodelling is associated with activation of proinflammatory cytokines the myocardium. To test hypothesis that exercise training can prevent myocardial production induced by β‐adrenergic hyperactivity, male Wistar rats were assigned one following four groups: sedentary non‐treated (Con); isoprenaline treated (Iso); exercised (Ex); plus (Iso+Ex). Echocardiography, haemodynamic...
systemic arterial hypertension is the most prevalent cardiovascular disease; physical activity for hypertensive patients related to several beneficial adaptations. This paper evaluated effect of water- and land-ergometry exercise sessions on post-exercise hypotension (PEH) healthy normotensive subjects versus treated or untreated patients.Forty-five older women composed three experimental groups: (N, n = 10), (TH, 15) (UH, 20). The acute session protocol was performed at 75% maximum oxygen...
In studies utilizing the isolated isovolumic blood-perfused canine heart, left ventricular pressure was measured following a sudden expansion of volume. An increase in performance occurred two phases: first, there an instantaneous rise developed simultaneous with distension; second phase, continued to for several minutes until final steady state reached. The immediate prolongation time-to-peak pressure, and no further change during time-dependent pressure. another series experiments,...
To assess the level of physical activity in public school teachers.Cross-sectional study conducted with 1,681 teachers from city São Paulo, southeastern Brazil, 2009. The International Physical Activity Questionnaire short version was applied and categorized as low, moderate or high. sample stratified by age, gender area (south east). chi-square test used for comparisons at a 5% significance.The prevalence high levels 46.3%, 42.7% 11%, respectively. Low more prevalent among those aged 31 to...
Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions, even when inflammation is a secondary consequence, such myocardial infarction (MI). However, the mechanism by which LLLT able to protect remaining myocardium remains unclear. The present study tested hypothesis that reduces after acute MI female rats and ameliorates cardiac function. potential participation of Renin-Angiotensin System (RAS) Kallikrein-Kinin (KKS) vasoactive peptides...
Triphenyltetrazolium chloride (TTC) staining and echocardiography (ECHO) are methods used to determine experimental myocardial infarction (MI) size, whose practical applicability should be expanded. Our objectives were analyze the accuracy of ECHO in determining size rats during first days following coronary occlusion test whether a simplified single measurement by TTC correctly indicates MI as determined average value for multiple slices. Infarction was induced female Wistar artery analysis...
1. The aim of the present study was to evaluate effect swimming on myocardial remodelling after infarction (MI) in female rats induced by coronary occlusion, which not performed sham rats. 2. Rats were divided six groups, three sedentary (sham (SSh; n = 14), moderate infarct (SMI; 8) and large (SLI; 10)) trained (TSh; 16), (TMI; 9) (TLI; 8)) groups. Training (8 weeks, 60 min/day, 5 days/week) initiated 4 weeks MI or operation. did affect mortality rate, but attenuated increases...
Sympathetic hyperactivity induces adverse effects in myocardial. Recent studies have shown that exercise training cardioprotection against sympathetic overload; however, relevant mechanisms of this issue remain unclear. We analyzed whether can prevent pathological hypertrophy induced by with modulation the kallikrein-kinin and angiogenesis pathways. Male Wistar rats were assigned to non-trained group received vehicle; isoproterenol treated (Iso, 0.3 mg kg−1 day−1); trained (Iso+Exe) which...
We investigated whether low-level laser therapy (LLLT) prior to or post resistance exercise could attenuate muscle damage and inflammation. Female Wistar rats were assigned non-LLLT LLLT groups. An 830-nm DMC Laser Photon III was used irradiate their hind legs with 2J, 4J, 8J doses. Irradiations performed (4J) bouts. Resistance consisted of four maximum load climbs. The work during a bout similar between Control (non-LLLT, 225 ± 10 g), 2J (215 8 4J (210 9 (226 g) Prior did not induce...