A5069466726- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Sleep and related disorders
- Stress Responses and Cortisol
- Pectus Deformity Diagnosis and Treatment
- Shoulder and Clavicle Injuries
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Muscle metabolism and nutrition
- Genetics and Physical Performance
- High Altitude and Hypoxia
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Shoulder Injury and Treatment
- Nerve injury and regeneration
- Neurological diseases and metabolism
- Nerve Injury and Rehabilitation
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
Universidade Federal de São Paulo
2013-2025
Fundação de Apoio à Universidade Federal de São Paulo
2021
Associação Paulista de Medicina
1995
The methods used to induce paradoxical sleep (PS) deprivation are believed be stressful. In the present study, two were compared in regard their ability activate hypothalamic‐pituitary‐adrenal (HPA) axis. Animals placed on multiple large (MLP) or small (MSP) platforms single (SLP) (SSP) and blood sampled at end of a 4‐day period PS (experiment 1) Days 1 (short‐term) 4 (long‐term) 2). ACTH corticosterone (CORT) levels determined by RIA. results experiment showed that all experimental animals...
RATS were deprived of sleep for 96 h by the platform technique and total glutathione (GSHτ) levels measured in seven different brain areas. Glutathione found to be significantly reduced hypothalamus sleep-deprived animals when compared with large (−18%) or home cage (−31%) controls. Deprived rats also had GSHπ thalamus controls only. did not differ among three groups any other areas examined. These results indicate that specific may differentially susceptible oxidative stress after...
Abstract Numerous studies indicate that sleep deprivation alters energy expenditure. However, this conclusion is drawn from indirect measurements. In the present study, we investigated alterations of expenditure, body composition, blood glucose levels, plasma insulin, adrenocorticotropic hormone (ACTH) and corticosterone levels immediately after 4 days or recovery. Rats were deprived maintained in a control environment (groups sleep‐deprived/deprivation control/deprivation). One half these...
Older adolescents tendo to stay awake longer in the evening and prefer rise later but it is still unclear if these sleep changes occur as become older or more pubertally mature. This was investigated a cross-sectional study with community sample of 121 9-to-17-year-old Brazilian who informed on their circadian preferences (Morningness-Eveningness Scale for Children: MESC) habits [bed/rise times weekdays weekends, time bed (TIB) social jetlag]. We analyzed factors according four development...
Adolescence is marked by physiological and social changes, such as puberty, increased responsibilities earlier school start times. This often leads to insufficient sleep on nights the need compensate for lost weekends, causing a misalignment between biological times, which has been termed jetlag (SJL). SJL triggers stress responses associated with several negative health outcomes, including higher cardiometabolic risk in adults. In adolescence, however, only consistently related increases...
Sleep quality is essential for health, with sleep deprivation linked to physical and mental issues. Homeless populations face additional challenges, yet this topic remains underexplored. This study assessed among homeless individuals in São Paulo, Brazil, considering demographics substance use. A psychiatrist conducted interviews collect demographic use data assessing using the Pittsburgh Quality Index (PSQI). Generalized Linear Model analyzed PSQI scores, sleeping location, gender, use,...
Evaluation of modafinil effects on the inhibitory avoidance task (IA).Rats were trained a multiple trial IA after receiving or vehicle injections. In experiment 1 they with weak protocol under baseline condition and in 2, stronger sleep-deprivation condition.In improved rats' acquisition whereas retention test remained unaffected. Experiment 2 did not interfere training performance, but lower dose prevented impairment sleep-deprived animals.Modafinil is able to improve normal rats reverse...
Recent indications of oxidative stress in hypothalamus sleep deprived rats prompted us to address the possibility that deprivation may induce pathological cell loss changes brain. Indices necrosis and apoptosis were quantified after 96 h induced by classical platform technique rats. Binding peripheral-type benzodiazepine ligand [³H]PK 11195 reactive astrocytes, a reliable sensitive index necrotic changes, was not altered any 14 brain regions examined. Likewise, no found mRNA levels...
Abstract Behavioral sensitization to ethanol's stimulant effect has been proposed as a marker for individual abuse liability. In previous work we have demonstrated that mice showing an increased propensity EtOH had higher levels of dopamine (DA) D2 receptor binding in localized brain areas compared less sensitization. the present study examined whether altered D1 or DA transporter (DAT) might also be associated with differential develop Male Swiss received 2.4 g/kg saline intraperitoneally...
Abstract To compare outcomes between autologous fascia lata and hamstring grafts for chronic pectoralis major muscle (PMM) rupture repair, perform histological, imaging analyses. Forty male patients with PMM ruptures (time since injury ranging from >3 months to 5 years) a mean age of 37.3 years (SD = 9.7 were evaluated. One group (20 patients) received an semitendinosus graft, another graft reconstruction. These by Bak 2criterium 60% the presented excellent results, 20% good 15% fair...
Hyperhomocysteinemia has been associated with pathological and stressful conditions is a risk factor for cardiovascular disease. Since sleep deprivation condition that disruption of various physiological processes, we investigated whether it would also be increases in plasma homocysteine levels. Further, since hyperhomocysteinemia may promote oxidative stress, had previously found evidence stress brain following deprivation, searched systemic by measuring glutathione thiobarbituric acid...
Abstract Cellular prion protein ( P rP C ) is widely expressed in the brain. Although precise role of remains uncertain, it has been proposed to be a pivotal modulator neuroplasticity events by regulating glutamatergic and serotonergic systems. Here we report existence neurochemical functional interactions between dopaminergic system. was found co‐localize with neurons synapses striatum. Furthermore, genetic deletion down‐regulated dopamine D 1 receptors DARPP ‐32 density striatum decreased...