A5019081879- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Work-Related Fatigue
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Obesity, Physical Activity, Diet
- Dysphagia Assessment and Management
- Epilepsy research and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sports Performance and Training
- Stress Responses and Cortisol
- Physical Activity and Health
- Memory and Neural Mechanisms
- High Altitude and Hypoxia
- Cardiovascular Syncope and Autonomic Disorders
Universidade Federal de São Paulo
2016-2025
Associação Fundo de Incentivo à Pesquisa
2009-2024
Fundação de Apoio à Universidade Federal de São Paulo
2010-2024
Instituto do Sono
2005-2023
Universidade de São Paulo
2008-2019
Universidade Federal de Minas Gerais
2015-2018
Fundação de Amparo à Pesquisa do Estado de São Paulo
1976-2018
Universidade Estadual Paulista (Unesp)
2018
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2018
Hospital Santa Marcelina
2016-2017
The goal of the current study was to estimate prevalence sleep bruxism (SB) in general population using a representative sample 1,042 individuals who answered questionnaires and underwent polysomnography (PSG) examinations. After PSG, were classified into 3 groups: absence SB, low-frequency high-frequency SB. results indicated that by confirmed 5.5%. With PSG used exclusively as criterion for diagnosis, 7.4% regardless SB self-reported complaints. alone, 12.5%. Of 5.5% (n = 56) with 26 30...
A recent study of patients with moderate-severe obstructive sleep apnea (OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We sought to verify this finding a new cohort examine the generalizability OSA an international ethnically diverse cohort.Using data 972 (apnea-hypopnea index [AHI] ≥ 15 events per hour) recruited from Sleep Apnea Global Interdisciplinary Consortium (SAGIC), we performed latent class analysis 18 self-reported symptom variables,...
The objective of the present study was to assess toxicology melatonin (10 mg), administered for 28 days 40 volunteers randomly assigned groups receiving either (N=30) or placebo (N=10) in a double‐blind fashion. following measurements were performed: polysomnography (PSG), laboratory examinations, including complete blood count, urinalysis, sodium, potassium and calcium levels, total protein albumin, glucose, triglycerides, cholesterol, high‐density lipoprotein (HDL), low‐density (LDL), very...
Voltage-gated sodium channels are required for the initiation and propagation of action potentials. Mutations in neuronal voltage-gated channel SCN1A associated with a growing number disorders including generalized epilepsy febrile seizures plus (GEFS+),(7) severe myoclonic infancy, familial hemiplegic migraine. To gain insight into effect mutations on excitability, we introduced human GEFS+ mutation SCN1A-R1648H orthologous mouse gene. Scn1a(RH/RH) mice homozygous R1648H exhibit spontaneous...
The objective of this study is to analyze the influence a previously reported hPer3 gene-length polymorphism in delayed sleep-phase syndrome and morningness-eveningness tendencies at low latitudes southern hemisphere.We have genotyped length gene characterized by short repeat allele (4-repeat) long (5-repeat).Seventeen patients with syndrome; 156 volunteers chosen according Horne-Ostberg questionnaire morning, intermediate, or evening preference; 110 no score as sample general population.We...
▪ Abstract Objective: To investigate whether active anodal transcranial direct current stimulation (tDCS) (of dorsolateral prefrontal cortex [DLPFC] and primary motor [M1]) as compared to sham treatment is associated with changes in sleep structure fibromyalgia. Methods: Thirty‐two patients were randomized receive or tDCS the anode centered over M1 DLPFC (2 mA, 20 minutes for five consecutive days). A blinded evaluator rated clinical symptoms of All‐night polysomnography was performed before...
To evaluate if a portable monitor could accurately measure the apnea-hypopnea index (AHI) in patients with suspicion of obstructive sleep apnea (OSA). Prospective and randomized. Sleep laboratory. 80 participants: 70 clinical OSA 10 subjects without OSA. N/A Three-order randomized evaluations were performed: (1) STD (Stardust II) used at participants' home (STD home), (2) simultaneously PSG lab (STD+PSG lab), (3) performed (PSG lab). Four AHI values generated analyzed: (a) home; (b) from...
The fear and uncertainty caused by the coronavirus disease 2019 (COVID-19) pandemic, threats to survival are one of main problems everyday life; however, mental health care must also be considered a priority. During social isolation called self-quarantine, restricted mobility contact, concern about financial resources availability supplies, infection, questions duration cause anxiety, depression, stress, insomnia reduced quality quantity sleep, that may present greater risk general...
Rationale: Apnea-hypopnea index (AHI) used for the diagnosis of obstructive sleep apnea (OSA) captures only frequency respiratory events and has demonstrable limitations. Objective: We propose a novel automated measure termed ventilatory burden (VB) that represents proportion overnight breaths with less than 50% normalized amplitude show its ability to overcome limitations AHI. Methods: Data from two epidemiological cohorts (Sao Paolo Epidemiological Study (EPISONO), Sleep Heart Health...
Abstract Objectives/Hypothesis To identify upper airway and craniofacial abnormalities is the principal goal of clinical examination in patients with obstructive sleep apnea–hypopnea syndrome. The aim was to anatomical that could be seen during a simple physical determine their correlation index (AHI). Study Design Consecutive syndrome who were evaluated public otorhinolaryngology center studied. Methods Adult previously polysomnography met inclusion criteria. All subjects underwent history...
This study was designed to evaluate the variability of apnoea–hypopnoea index (AHI) in 20 patients with obstructive sleep syndrome (OSAHS) and determine possible relationships this other polysomnographic parameters. The subjects were recorded on four consecutive nights. mean AHI values not significantly altered throughout recording nights ( P =0.67). intraclass correlation coefficient 0.92. However, Bland Altman plot showed that, individually, presented an important variability, which...
Examine the effects of donepezil on sleep and rapid eye movement (REM) electroencephalogram (EEG) in patients with Alzheimer disease, using polysomnography, correlation between REM EEG parameters cognitive scores.Randomized, double-blind, placebo-controlled design.Two research centers, University Hospital.Thirty-five mild to moderate allocated 2 groups: treated (n=17) placebo (n=18).Patients were administered or placebo.Polysomnography spectral analysis evaluation Disease Assessment Scale,...
The purposes of this study were to assess the relationship between different increments mandibular protrusion and a reduction obstructive sleep apnea (OSA) severity use magnetic resonance imaging temporomandibular joint (TMJ) morphology condyle position after insertion an oral appliance (OA). Six mild moderate OSA patients treated with titratable OA (KlearwayTM) changes in hypopnea index (AHI) secondary amount advancement evaluated. In seven patients, TMJ was compared before titration...