A5085704684- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Effects of Vibration on Health
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Medical research and treatments
- Sex work and related issues
- Physical Education and Gymnastics
- Psychedelics and Drug Studies
- Migration, Aging, and Tourism Studies
- Nicotinic Acetylcholine Receptors Study
- Children's Physical and Motor Development
- Neuroinflammation and Neurodegeneration Mechanisms
Universidade Federal de São Paulo
2003-2019
Universidade Federal do ABC
2013-2014
The nonselective muscarinic antagonist scopolamine is known to impair the acquisition of some learning tasks such as inhibitory avoidance. There has been recent research into effects this drug in contextual fear conditioning and tone paradigms. purpose present study was assess role selective M1 dicyclomine these paradigms avoidance test. Rats were administered different doses or saline 30 min before training. animals tested 24 hr later, it observed that 16 mg/kg impaired both However, (up 64...
Evaluation of modafinil effects on the inhibitory avoidance task (IA).Rats were trained a multiple trial IA after receiving or vehicle injections. In experiment 1 they with weak protocol under baseline condition and in 2, stronger sleep-deprivation condition.In improved rats' acquisition whereas retention test remained unaffected. Experiment 2 did not interfere training performance, but lower dose prevented impairment sleep-deprived animals.Modafinil is able to improve normal rats reverse...
Nociceptin, or orphanin FQ (N/OFQ), the endogenous ligand of NOP receptors, is known to regulate learning and memory processes. To verify role N/OFQ in acquisition contextual (CFC) tone fear conditioning (TFC), Wistar male rats received intracerebroventricular injections (0.1-5.0 nmol) before training, were tested 24 48 hr later access freezing response context tone, respectively. The intermediate doses (1.0 2.5 impaired CFC test, sparing TFC. highest dose (5.0 reduced during both tests, a...
Pre-training rapid eye movement sleep (REMS) deprivation affects memory acquisition and/or consolidation. It also produces major REMS rebound at the cost of waking and slow wave (SWS). Given that both SWS appear to be important for processes, after training may disrupt organization cycles, i.e., excessive amount little could harmful formation.To examine whether lithium, a drug known increase reduce REMS, prevent impairment induced by pre-training deprivation.Animals were divided in 2 groups:...
Abstract Cellular prion protein ( P rP C ) is widely expressed in the brain. Although precise role of remains uncertain, it has been proposed to be a pivotal modulator neuroplasticity events by regulating glutamatergic and serotonergic systems. Here we report existence neurochemical functional interactions between dopaminergic system. was found co‐localize with neurons synapses striatum. Furthermore, genetic deletion down‐regulated dopamine D 1 receptors DARPP ‐32 density striatum decreased...
Numerous studies show that sleep deprivation (SD) impacts negatively on cognitive processes, including learning and memory. Memory formation encompasses distinct phases of which acquisition, consolidation retrieval are better known. Previous with pre-training SD induced by the platform method have shown impairment in fear conditioning tasks. Nonetheless, manipulations do not allow distinction between effects acquisition and/or consolidation, interfering, ultimately, recall of/performance...
Impaired cholinergic neurotransmission can affect memory formation and influence sleep-wake cycles (SWC). In the present study, we describe SWC in mice with a deficient vesicular acetylcholine transporter (VAChT) system, previously characterized as presenting reduced release cognitive behavioral dysfunctions. Continuous, chronic ECoG EMG recordings were used to evaluate pattern during light dark phases VAChT knockdown heterozygous (VAChT-KDHET, n=7) wild-type (WT, mice. evaluated for sleep...
Increasing evidence indicates that sleep deprivation (SD) alters responses to pharmacological agents by affecting specific transmitter systems. The present work addressed deficits in passive avoidance (PA) performance are seen after SD, and investigated whether treatment with the inverse benzodiazepine agonist beta-CCM could prevent such deficits. Male Wistar rats were deprived of for 96 h using platform method (SD group), or then allowed recover 24h (SR group). Animals treated saline...
ABSTRACT Objective To describe the socioeconomic and demographic characteristics of trans population in Baixada Santista region, São Paulo state. Methods This was a descriptive study involving adult people, selected through convenience sampling 2023. A quantitative questionnaire administered in-depth interviews were conducted, which analyzed using thematic grouping. Results total 237 people recruited. Of these, 42.2% identified as women/travestis 36.3% men/ transmasculine; 65.4% aged up to...
RESUMO Objetivo Descrever as características socioeconômicas e demográficas da população trans Baixada Santista. Métodos Trata-se de estudo descritivo, com pessoas adultas, selecionadas por amostra conveniência em 2023. Foi aplicado questionário quantitativo realizadas entrevistas profundidade, analisadas agrupamento temático. Resultados Foram recrutadas 237 pessoas. Dessas, 42,2% se identificaram como mulher trans/travesti 36,3% homem trans/transmasculino; 65,4% tinham até 29 anos idade;...