A5088158492- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- MicroRNA in disease regulation
- Genetics and Physical Performance
- Renin-Angiotensin System Studies
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Circular RNAs in diseases
- Heart Rate Variability and Autonomic Control
- Sports Performance and Training
- Cardiovascular Function and Risk Factors
- Hormonal and reproductive studies
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Pharmacological Effects and Assays
- Peripheral Artery Disease Management
- Nitric Oxide and Endothelin Effects
- Extracellular vesicles in disease
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Birth, Development, and Health
Universidade de São Paulo
2015-2024
University of South Florida
2023-2024
Universidade Federal dos Vales do Jequitinhonha e Mucuri
2024
Grupo Hospitalar Conceição
2023
Universidade Federal de Minas Gerais
2022
National Council for Scientific and Technological Development
2020
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2020
Hospital São Paulo
2020
James Cook University
2020
Laboratoire de Biochimie
2004-2018
Aerobic exercise training leads to a physiological, nonpathological left ventricular hypertrophy; however, the underlying biochemical and molecular mechanisms of physiological hypertrophy are unknown. The role microRNAs regulating classic novel cardiac renin-angiotensin (Ang) system was studied in trained rats assigned 3 groups: (1) sedentary; (2) swimming with protocol 1 (T1, moderate-volume training); (3) 2 (T2, high-volume training). Cardiac Ang I levels, Ang-converting enzyme (ACE)...
MiRNAs regulate cardiac development, hypertrophy, and angiogenesis, but their role in hypertrophy (CH) induced by aerobic training has not previously been studied. Aerobic promotes physiological CH preserving function. This study assessed involvement of miRNAs-29 trained rats. Female Wistar rats (n=7/group) were randomized into three groups: sedentary (S), 1 (T1), 2 (T2). T1: swimming sessions 60 min/5 days/wk/10 wk. T2: similar to T1 until 8th On the 9th wk swam 2×/day, on 10th 3×/day....
MicroRNA (miRNA)-126 is angiogenic and has two validated targets: Sprouty-related protein 1 (Spred-1) phosphoinositol-3 kinase regulatory subunit 2 (PI3KR2), negative regulators of angiogenesis by VEGF pathway inhibition. We investigated the role swimming training on cardiac miRNA-126 expression related to angiogenesis.Female Wistar rats were assigned three groups: sedentary (S), (T1, moderate volume), (T2, high volume). T1 consisted 60 min·d swimming, five times per week for 10 wk with 5%...
Aerobic exercise training (ET) lowers hypertension and improves patient outcomes in cardiovascular disease. The mechanisms of these effects are largely unknown. We hypothesized that ET modulates microRNAs (miRNAs) involved vascularization. miRNA-16 regulates the expression vascular endothelial growth factor antiapoptotic protein Bcl-2. miRNA-21 targets miRNA-126 functions by repressing regulators pathway. investigated whether miRNA-16, -21 -126 modulated ET. Twelve-week-old male...
Regular physical activity is an effective non-pharmacological therapy for prevention and control of hypertension. We investigated the effects aerobic exercise training in vascular remodelling mechanical functional alterations coronary small mesenteric arteries from spontaneously hypertensive rats (SHR).Normotensive Wistar Kyoto (WKY), SHR trained on a treadmill 12 weeks were used to evaluate structural, properties.Exercise did not affect lumen diameter, wall thickness wall/lumen ratio but...
The effect of swimming training (ST) on vagal and sympathetic cardiac effects was investigated in sedentary (S, N = 12) trained (T, male Wistar rats (200-220 g). ST consisted 60-min sessions 5 days/week for 8 weeks, with a 5% body weight load attached to the tail. autonomic nervous system generating training-induced resting bradycardia (RB) examined indirectly after muscarinic adrenergic receptor blockade. Cardiac hypertrophy evaluated by myocyte morphometry. Plasma catecholamine...
We evaluated the effects of swimming and anabolic steroids (AS) on ventricular function, collagen synthesis, local renin-angiotensin system in rats. Male Wistar rats were randomized into control (C), steroid (S; nandrolone decanoate; 5 mg/kg sc, 2x/wk), + losartan (SL; 20 mg.kg(-1).day(-1)), trained (T), (T+S), (T+SL; n = 14/group) groups. Swimming was performed times/wk for 10 wk. Serum testosterone increased S T+S. Resting heart rate lower T Percent change left (LV) weight-to-body weight...
Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls are altered in heart failure (HF), which seems to be due changes cyclooxygenase (COX) pathway receptors on afferent neurons, including transient receptor potential vanilloid type-1 (TRPV1) cannabinoid (CB1). The purpose of the present study was test hypotheses: 1) exercise training (ET) alters control sympathetic nerve activity (MSNA) HF patients. 2) alteration is accompanied by increased expression TRPV1...
Myocardial infarction (MI) is accompanied by cardiac growth, increased collagen deposition, cell death and new vascularization of the tissue, which results in reduced ventricular compliance. The MiRNA-29 family (29a, 29b, 29c) targets mRNAs that encode collagens other proteins involved fibrosis. In this study we assessed effects swimming training (ST) on expression miRNA-29 genes encoding after MI rats.ST consisted 60 min/day/10 weeks began four MI. MiRNA analysis were performed infarcted...
Background Accumulated evidence shows that the ACE-AngII-AT1 axis of renin-angiotensin system (RAS) is markedly activated in chronic heart failure (CHF). Recent studies provide information Angiotensin (Ang)-(1–7), a metabolite AngII, counteracts effects AngII. However, this balance between AngII and Ang-(1–7) still little understood CHF. We investigated exercise training on circulating skeletal muscle RAS ischemic model Methods/Main Results Male Wistar rats underwent left coronary artery...
SUMMARY 1. The present study sought to evaluate cardiovascular adaptations, such as blood pressure (BP), heart rate (HR) and cardiac hypertrophy, resistance training (RT) in a rat model. 2. protocol consisted of four sets 10–12 repetitions the squat exercise performed at 65–75% one repetition maximum (1RM) over 4 weeks. Animals were randomly divided into three groups: control ( n = 8, CO), electrically stimulated ES) trained TR; also stimulated). Blood HR measured by direct method conscious...
Aerobic exercise training has been established as an important nonpharmacological treatment for hypertension. We investigated whether the number and function of endothelial progenitor cells (EPCs) are restored after training, potentially contributing to neovascularization in hypertension.Twelve-week-old male spontaneously hypertensive rats (SHRs, n = 14) Wistar-Kyoto (WKY, were assigned four groups: SHR; trained SHR (SHR-T); WKY; WKY. Exercise consisted 10 weeks swimming. EPC function, well...
In order to verify the effects of heat and exercise acclimation (HA) on resting exercise-induced expression plasma leukocyte shock protein 72 (Hsp72) in humans, nine healthy young male volunteers (25.0 ± 0.7 years; 80.5 2.0 kg; 180 2 cm, mean SE) exercised for 60 min a hot, dry environment (40 0°C 45 0% relative humidity) 11 days. The protocol consisted running treadmill using controlled hyperthermia technique which work rate was adjusted elevate rectal temperature by 1°C 30 maintain it...
Objective Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity cardiac RAS activation. The study hypothesis was to investigate whether its association with EXT alter the systemic components an obese Zucker rat strain. Methods rats were divided into following groups: Lean (LZR); lean plus (LZR+EXT); (OZR) (OZR+EXT). consisted of 10 weeks 60-min swimming sessions, 5 days/week. At...
Impaired cardiomyocyte contractility and calcium handling are hallmarks of left ventricular contractile dysfunction. Exercise training has been used as a remarkable strategy in the treatment heart disease. The microRNA-1, which targets sodium/calcium exchanger 1 (NCX), microRNA-214, sarcoplasmic reticulum ATPase-2a (Serca2a), involved cardiac function regulation. Thus, aim this study was to evaluate effect exercise on microRNA-1 -214 expression after myocardial infarction.Wistar rats were...
Aerobic exercise-induced cardiac hypertrophy (CH) is a physiological response involving accurate orchestration of gene and protein expression contractile metabolic components. The microRNAs: miR-208a, miR-208b miR-499 are each encoded by myosin thus also known as 'MyomiRs', regulating several mRNA targets that in turn regulate CH pathways. To understand the role myomiRs fine-tuning heavy chain (MHC) isoform exercise training-induced hypertrophy, Wistar rats were subjected to two different...
Background . We previously reported that exercise training (ET) facilitates the clearance of damaged proteins in heart failure. Here, we characterized impact ET on cardiac protein quality control during compensated ventricular hypertrophy spontaneously hypertensive rats (SHR). Methods and Results SHR were randomly assigned into sedentary swimming-trained groups. Sedentary displayed with preserved function compared to normotensive rats, characterizing a hypertrophy. Hypertensive presented...