A5053393012- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
- Neuroendocrine regulation and behavior
- Nitric Oxide and Endothelin Effects
- Biochemical effects in animals
- Circadian rhythm and melatonin
- Eicosanoids and Hypertension Pharmacology
- Pelvic floor disorders treatments
- Respiratory Support and Mechanisms
- Renin-Angiotensin System Studies
- High Altitude and Hypoxia
- Cardiovascular Syncope and Autonomic Disorders
- Thyroid Disorders and Treatments
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Urinary Tract Infections Management
- Mechanical Circulatory Support Devices
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Anesthesia and Neurotoxicity Research
- Hemoglobin structure and function
- Apelin-related biomedical research
Faculdade de Medicina do ABC
2016-2025
Hospital Universitário da Universidade de São Paulo
2022
Universidade Federal de São Paulo
1999-2022
Universidade Nove de Julho
2022
Centro Universitário de Barra Mansa
2022
Union des Industries Ferroviaires Européennes
2004-2022
Universidade Federal Rural do Rio de Janeiro
2022
Universidade Presbiteriana Mackenzie
2022
Fundação do ABC
2019
Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória
2019
Urinary stress incontinence has a high prevalence in women, with many associated risk factors, such as impact and intensity sports due to increased intra-abdominal pressure causing stretching weakening of the pelvic floor muscles. No previous study investigated effects undulatory resistance training (URT), deemed sports’s modality, on urinary bladder (UB) tissue remodeling. Healing depends equilibrium metalloproteinases (MMPs) their inhibitors (TIMPS). We aimed investigate histomorphological...
Many studies have investigated the importance of oxidative stress on cardiovascular system. In this study we evaluated effects central catalase inhibition cardiopulmonary reflex in conscious Wistar rats. Male rats were implanted with a stainless steel guide cannula fourth cerebral ventricle. The femoral artery and vein cannulated for mean arterial pressure heart rate measurement drug infusion, respectively. After basal recordings, was tested dose phenylbiguanide (PBG, 8 μg/kg, bolus)....
Introduction:In this study we aimed to evaluate the peak cough flow (PCF) in healthy Brazilian subjects.Methods: We evaluated 484 subjects between 18 and 40 years old.Subjects were seated oriented asked perform a maximal inspiration followed by quick, short explosive expiration on meter.Three measures carried out recorded average of three results for each individual. Results:The PCF values ranged 240 500 L/min.The lower females than males.The was inversely proportional age. Conclusion:The...
Abstract — It has been suggested that increased sympathetic activity and arterial chemoreceptors are important for the high blood pressure in spontaneously hypertensive rats (SHR). Electrolytic lesions of commissural nucleus solitary tract (commNTS) abolish (1) cardiovascular responses to chemoreflex activation with potassium cyanide (KCN) normotensive (2) hypertension follows acute aortic baroreceptor denervation rats. Therefore, this study we investigated effects electrolytic commNTS on...
This study aimed to investigate whether previous exercise training could prevent or attenuate acute cardiac alterations after myocardial infarction.Female rats were submitted swim (1 h/day; 5 days/week) allowed remain sedentary for 8 weeks. Afterwards, they randomly assigned left coronary artery occlusion sham surgery. After this procedure, the remained one week until euthanasia. Cardiac structural and functional analyses performed using Doppler echocardiography. The that had a moderate...
Neurons in the commissural nucleus of solitary tract (commNTS) play an important role certain cardiovascular responses dependent on sympathetic vasoconstrictor activation, including arterial chemoreceptor reflex. Electrolytic lesions commNTS elicit a fall pressure (AP) spontaneously hypertensive rats (SHR). To determine whether latter result 1) arose from elimination neuronal activity rather than en passant axons and 2) was accompanied by reduction nerve activity, we evaluated effect...
In the present study, we investigated effects of inhibition caudal ventrolateral medulla (CVLM) with GABA(A) agonist muscimol combined blockade glutamatergic mechanism in nucleus solitary tract (NTS) kynurenic acid (kyn) on mean arterial pressure (MAP), heart rate (HR), and regional vascular resistances. male Holtzman rats anesthetized intravenously urethane/chloralose, bilateral injections (120 pmol) into CVLM or kyn (2.7 nmol) NTS alone increased MAP to 186 +/- 11 142 6 mmHg, respectively,...
Purpose: To compare baroreflex sensitivity among conscious rats of the same strain. 
 Methods: Male WKY (eight weeks old) were studied. Cannulas inserted into abdominal aortic artery through right femoral to measure mean arterial pressure (MAP) and heart rate (HR). Baroreflex gain was calculated as ratio between variation HR in function MAP (?HR/?MAP) tested with a depressor dose sodium nitroprusside (SNP, 50µg/kg, iv) pressor phenylephrine (PE, 8µg/kg, iv). We divided four groups: 1)...
Inhibition of the commissural nucleus solitary tract (commNTS) induces a fall in sympathetic nerve activity and blood pressure spontaneously hypertensive rats (SHR), which suggests that this subnucleus NTS is source sympathoexcitation. Exercise training reduces arterial pressure. The purpose present study was to investigate whether swimming exercise can modify regional vascular responses evoked by inhibition commNTS neurons SHR normotensive Wistar-Kyoto (WKY) rats. consisted swimming, 1...
In this minireview we describe the involvement of atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role exerts complex effects on cardio-circulatory hemodynamics, it is produced by left atrium key regulating sodium water balance mammals humans. dominant stimulus for its release wall tension, commonly caused involved process lipolysis through cGMP signaling pathway and, as consequence, reducing blood pressure decreasing...
Cigarette exposure increases brain oxidative stress. The literature showed that increased stress affects cardiovascular regulation. However, no previous study investigated the involvement of in animals exposed to cigarette and its relationship with We aimed evaluate effects central catalase inhibition on baroreflex responses rats sidestream smoke (SSCS). evaluated males Wistar (320-370 g), which were implanted a stainless steel guide cannula into fourth cerebral ventricle (4th V). Femoral...
Nitric oxide (NO) and α 2 ‐adrenoceptor imidazoline agonists such as moxonidine may act centrally to inhibit sympathetic activity decrease arterial pressure. In the present study, we investigated effects of pretreatment with L ‐NAME (NO synthesis inhibitor), injected into 4th ventricle (4th V) or intravenously (i.v.), on hypotension, bradycardia vasodilatation induced by V in normotensive rats. Male Wistar rats a stainless steel cannula implanted anaesthetized urethane were used. Blood flows...
Exogenous catalase influences neural control of cardiovascular system; however, we do not know yet if its inhibition into the fourth cerebral ventricle (4(th) V) baroreflex regulation. We evaluated effects central on in conscious Wistar rats. used males rats (320-370 g), which were implanted with a stainless steel guide cannula 4(th) V. The femoral artery and vein cannulated for mean arterial pressure (MAP) heart rate (HR) measurement drug infusion, respectively. After basal MAP HR...
Exercise training reduces sympathetic activity in hypertensive humans and rats. We hypothesized that the swimming exercise would change neurotransmission rostral ventrolateral medulla (RVLM), a key region involved outflow, hemodynamic control spontaneously rats (SHR) Wistar-Kyoto (WKY) Bilateral injections of kynurenic acid (KYN) were carried out RVLM sedentary- (S-) or exercised- (E-) SHR WKY submitted to for 6 weeks. Rats were<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Vancomycin (VCM) is indicated in combat against Gram-positive infections, but it not considered a first-choice drug because of its adverse effects. It believed that oxidative stress the primary mechanism endothelial injury and consequent VCM toxicity, which varies from phlebitis to nephrotoxicity. Moreover, dose recommendations, dilution, rates types infusion are still controversial. The aim this study was determine effect different dilutions endothelial, liver kidney injuries by biochemical...
The side stream cigarette smoke (SSCS) is a contributing factor in the pathogenesis of smoking-induced toxicity. Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions functions tissues have similar actions by providing O2 (oxygen) for respiratory chain, detoxification ROS nitric oxide (NO), protect against irreversible lesions. We aimed to investigate effects SSCS exposure on gene protein expression Ngb, Cygb, Mb tissue. Ngb Cygb...
Abstract The present study examined the acute effects of static stretching (SS) exercise order on cardiac responses. Seventeen individuals were submitted to two experimental SS session: Order “A” (larger small muscles groups) and “B” (small larger groups). Heart rate (HR), systolic (SBP) diastolic blood pressure (DBP), rate-pressure product (RPP) oxygen saturation (SpO 2 ), heart variability (HRV) measured at rest, midpoint session, immediately after in 5, 10, 20 minutes after. increased HR...