A5020929207- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Electrochemical sensors and biosensors
- Diabetes and associated disorders
- HIV-related health complications and treatments
- Pancreatitis Pathology and Treatment
- Urological Disorders and Treatments
- Respiratory Support and Mechanisms
- Diabetes Treatment and Management
- Acute Ischemic Stroke Management
- Erythropoietin and Anemia Treatment
- Long-Term Effects of COVID-19
- Lysosomal Storage Disorders Research
Faculdade de Medicina do ABC
2016-2025
Hospital Estadual Mário Covas
2024
Centro Universitário FEI
2024
Centre Hospitalier Universitaire de Bordeaux
2019
General Department of Preventive Medicine
2018
Inserm
2017
Institut du Cerveau
2017
Centre National de la Recherche Scientifique
2017
Sorbonne Université
2017
Yahoo (United Kingdom)
2013
Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, a class of compounds that stimulate endogenous erythropoietin production.We conducted two randomized, open-label, noninferiority phase 3 trials to evaluate the safety and efficacy vadadustat, as compared with darbepoetin alfa, in patients anemia incident or prevalent dialysis-dependent chronic kidney disease (DD-CKD). The primary end point, assessed time-to-event analysis, was first occurrence major adverse...
Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of DAPA-CKD trial, we determined effects dapagliflozin on cardiovascular and non-cardiovascular causes death.DAPA-CKD was an international, randomized, placebo-controlled trial with a median 2.4 years follow-up. Eligible participants were adult patients CKD, defined as urinary albumin-to-creatinine ratio (UACR) 200-5000 mg/g estimated glomerular filtration rate (eGFR) 25-75...
This pre-specified analysis of DAPA-CKD assessed the impact sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function high-risk patients based having chronic disease (CKD) and substantial albuminuria. was a randomized, double-blind, placebo-controlled trial that had median follow-up 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200–5000 mg/g estimated glomerular filtration rate 25–75 mL/min/1.73m2) were randomized to dapagliflozin 10 mg/day matched...
Community-acquired pneumonia (CAP) is amongst the leading causes of death worldwide. As inflammatory markers, cytokines can predict outcomes, if interpreted together with clinical data and scoring systems such as CURB-65, CRB, Acute Physiology Chronic Health Evaluation II (APACHE II). The aim this study was to determine impact biomarkers on early mortality hospitalized CAP patients. Twenty-seven patients needing hospitalization were enrolled for samples interleukin-1 (IL-1) interleukin-6...
Introduction: The COVID-19 pandemic represented a challenge in prevention policy and medicine development. For the prevention, vaccines were fast developed to restrain disease’s spread. CoronaVac was among first available middle- low-income countries. Renal patients are usually excluded from vaccine trials, little is known about need for specific dose booster. This study aimed evaluate antibody response chronic kidney disease (CKD) after three months of vaccination. Methods: It...
Abstract: Hepatitis B is responsible for the development of half hepatocellular carcinoma cases and a major cause hepatic insufficiency. The vaccine against hepatitis virus does not exhibit same high efficacy in patients on hemodialysis as it immunocompetent individuals. medical literature recommends vaccination with four doses (40 mg each) before beginning hemodialysis; however, approximately one-third do respond to this schedule. A new serologic test should be performed each year...
IntroductionDiabetic nephropathy is associated with specific histological changes. Early detection of poor glomerular and tubular function can be achieved biomarkers diabetes. The aim this study was to evaluate the accuracy kidney dysfunction in type 2 diabetes (T2D).MethodsPatients T2D were grouped according their glycated hemoglobin level. Patients’ urine blood samples taken measure cystatin C (CysC), neutrophil gelatinase-associated lipocalin, beta-trace protein levels, first morning void...
Summary Introduction: Obstructive sleep apnea and hypopnea syndrome (OSAHS) is one of the developmental factors high blood pressure (HBP), a relevant global public health problem. OSAHS characterized by reduction or complete cessation respiratory airflow due to intermittent airway collapse. Additionally, significant changes in rhythm pattern are observed these patients. Objective: To evaluate association between quality essential resistant hypertensives. Method: A cross-sectional,...
Abstract There is an unmet medical need for effective treatments hospitalized patients with coronavirus disease 2019 (COVID‐19). Ribavirin a broad‐spectrum antiviral demonstrated in vitro activity against multiple viruses, including severe acute respiratory syndrome 2 (SARS‐CoV‐2). This trial evaluated the potential of ribavirin inhalation solution (ribavirin aerosol) to reduce COVID‐19 severity adults confirmed SARS‐CoV‐2 infection and diagnosis distress. phase I, multicenter, open‐label,...
Summary Introduction: acute coronary syndromes (ACS) represent a widely prevalent health issue with high mortality in Brazil and worldwide. The severity of ACS is not known patients the city São Bernardo do Campo municipality contiguous adjacent to Paulo. Objectives: study profile disease hospitalized who underwent angiography emergency room between 2012 2013. Methods: this an observational that included consecutive admitted hospital. Data collection was performed using medical records...
Introduction Diabetic nephropathy (DN) is a disease that progresses with the slow and progressive decline of glomerular filtration rate (GFR); installation this pathology silent one major causes death in patients diabetes. Aims To identify new molecular biomarkers for early identification onset DN type II diabetes mellitus (DM2). We studied expression profile genes; suppressor mothers against decapentaplegic 1 ( SMAD1 ), neutrophil gelatinase-associated lipocalin NGAL ) IV collagen COLIV1A...
Dyspepsia is a condition that affects 25% of the U.S. population, and, when associated with pyrosis, its prevalence reaches 40%. Patients chronic renal insufficiency not only present higher circulating levels gastrin and gastric dysmotilty, but also make use great amount drugs for treatment their comorbidities. This situation increases chances developing gastrointestinal symptoms. The aim current study to evaluate dyspeptic disease profile in patients undergoing hemodialysis, comparing them...
Vancomycin (VCM) is indicated in combat against Gram-positive infections, but it not considered a first-choice drug because of its adverse effects. It believed that oxidative stress the primary mechanism endothelial injury and consequent VCM toxicity, which varies from phlebitis to nephrotoxicity. Moreover, dose recommendations, dilution, rates types infusion are still controversial. The aim this study was determine effect different dilutions endothelial, liver kidney injuries by biochemical...
Chronic kidney disease (CKD) is highly prevalent worldwide. Patients with CKD on hemodialysis are more likely to present behavioral changes and worse quality of life as a result their routine complications. They also have higher levels cytokines. The aim this study assess the relationship between inflammatory profile measured by KDOQL-SF36 in outpatients. older than 21 years age for at least 6 months treatment regular weekly basis were included anthropometric parameters serum markers...