A5032315045- Ancient and Medieval Archaeology Studies
- Historical and Archaeological Studies
- Parkinson's Disease Mechanisms and Treatments
- Archaeology and ancient environmental studies
- European history and politics
- Cytokine Signaling Pathways and Interactions
- Archaeological Research and Protection
- Bone Metabolism and Diseases
- Neurological disorders and treatments
- Bone health and treatments
- Bone health and osteoporosis research
- Historical and Cultural Archaeology Studies
- Historical Geopolitical and Social Dynamics
- Pleistocene-Era Hominins and Archaeology
- Orthopaedic implants and arthroplasty
- Biochemical Analysis and Sensing Techniques
- German Literature and Culture Studies
- Taxation and Legal Issues
- Orthopedic Infections and Treatments
- Law and Political Science
- Estrogen and related hormone effects
- Olfactory and Sensory Function Studies
- Cultural Heritage Management and Preservation
- Central European national history
- Pharmacological Effects of Natural Compounds
Novartis (Switzerland)
2015-2025
Heidelberg University
2003-2024
University Hospital Heidelberg
1994-2024
University College London
2008-2024
Museum of London Archaeology
2013-2023
Novartis Institutes for BioMedical Research
2015
University Hospital Carl Gustav Carus
2012
TU Dresden
2000-2012
UCL Australia
2007
Heidelberg University
2007
Recent studies support the idea of olfactory dysfunction as a very early sign idiopathic Parkinson's disease (IPD). Aim present study was to clinically follow-up patients with hyposmia find out percentage developing IPD after 4 years time. At baseline, tests had been combined transcranial sonography substantia nigra and 123I-FP-CIT SPECT imaging. neurological examination, 7% individuals developed clinical IPD. Altogether, 13% presented abnormalities motor system. Our data suggest that...
The response of psoriasis to antibodies targeting the interleukin (IL)-23/IL-17A pathway suggests a prominent role T-helper type-17 (Th17) cells in this disease. We examined clinical and immunological patterns 100 subjects with moderate-to-severe receiving 3 different intravenous dosing regimens anti-IL-17A antibody secukinumab (1 × mg/kg or 1 10 on Day 1, Days 15 29) placebo phase 2 trial. Baseline biopsies revealed typical features active psoriasis, including epidermal accumulation...
Abstract Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether “idiopathic” olfactory dysfunction might relate to nigral degeneration. tests were combined with transcranial sonography substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed idiopathic participated. Eleven these exhibited an increased echogenicity SN in sonography. In 10 11 patients, SPECT scans 123 I‐FP‐CIT performed. Median uptake...
Abstract This study investigates the effects of kyphoplasty on pain and mobility in patients with osteoporosis painful vertebral fractures compared conventional medical management. Introduction: Pharmacological treatment primary does not prevent impaired activity fractures. Therefore, we evaluated clinical outcome after associated chronic for >12 months. Materials Methods: Sixty presenting months were included this prospective, nonrandomized controlled study. Twenty-four hours before...
Abstract This first‐in‐human study evaluated the safety, tolerability, single‐ and multiple‐dose pharmacokinetic profiles with dietary influence, pharmacodynamics (PD) of DFV890, an oral NLRP3 inhibitor, in healthy participants. In total, 122 participants were enrolled into a three‐part trial including single 2‐week multiple ascending doses (SAD MAD, respectively) randomized (3:1) to DFV890 or placebo [3–600 mg] MAD [fasted: 10–200 mg, once‐daily fed: 25 50 twice‐daily]). was generally...
Antibiotic-loaded PMMA bone cement is frequently used in modern trauma and orthopedic surgery. Although many of the antibiotics routinely applied are described to have cytotoxic effects literature, clinical experience shows no adverse for healing. To determine antibiotic-loaded spacers on osteogenesis vitro, we cultivated human marrow mesenchymal stem cells (BM-hMSCs) presence containing Gentamicin, Vancomycin, Gentamicin + Clindamycin as well Vancomycin addition a blank control (agarose)...
The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors and growth factor-induced signal transduction. C-terminal SOCS box region is thought to regulate protein stability most likely via an elongin C interaction. In the present study, we have found that phosphorylation SOCS3 at two tyrosine residues in conserved box, Tyr204 Tyr221, can inhibit SOCS3-elongin interaction activate proteasome-mediated degradation. Jak-mediated decreased half-life, both Tyr221 was required...
Angiogenesis is indispensable during fracture repair, and vascular endothelial growth factor (VEGF) critical in this process. CCN1 (CYR61) an extracellular matrix signaling molecule that has been implicated neovascularization through its interactions with several integrin receptors. shown to be up-regulated the reparative phase of healing; however, role therein remains unclear. Here, regulation expression osteoblasts functional consequences thereof were studied. Stimulation VEGF resulted a...
Persistent activation of the transcription factor STAT3 has been detected in many types cancer and plays an important role tumor progression, immune evasion metastasis. To analyze persistent we coexpressed with v-Src. We found that tyrosine phosphorylation by v-Src is independent Janus kinases (Jaks), canonical activators STATs. The STAT3-induced feedback inhibitor, suppressor cytokine signaling 3 (SOCS3), did not interfere However, protein inhibitor activated (PIAS3) suppressed gene...
Abstract Background Calcium phosphate cements are used frequently in orthopedic and dental surgeries. Strontium-containing drugs serve as systemic osteoblast-activating medication various clinical settings promoting mechanical stability of the osteoporotic bone. Methods calcium cement (SPC) (CPC) were compared regarding their local effects on bone tissue a standard animal model for A defect was created distal femoral metaphysis 60 ovariectomized Sprague-Dawley rats. CPC SPC to fill defects...
Inflammatory bowel disease (IBD) consists of chronic conditions that severely impact a patient's health and quality life. Interleukin-10 (IL-10), potent anti-inflammatory cytokine has strong genetic links to IBD susceptibility shown efficacy in rodent models, suggesting it great therapeutic potential. However, when tested clinical trials for IBD, recombinant human IL-10 (rhIL-10) showed weak inconsistent due its short half-life pro-inflammatory properties counteract the efficacy. Here we...
This article comprises a brief report on the 2023 excavations of an extensive Eneolithic cemetery undertaken as UCL collaboration with colleagues from Muzeul Județean Satu Mare.The site represents largest Middle Bodrogkeresztúr culture in Romania and has yielded grave finds, including items gold copper.
Abstract The current consensus recommendation papers dealing with the unique requirements for analytical validation of assays performed by flow cytometry address sensitivity (both and functional) only in general terms. In this paper, a detailed approach designing validating rare event methods is described. impact panel design optimization on lower limit quantification (LLOQ) suggestions reporting data near, or below, LLOQ are addressed. This paper serves to provide best practices...
Abstract Background This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only. Methods We assessed pain, disability parameters by visual analogue scale (VAS 0‐100), Oswestry Disability Index re‐evaluating available follow‐up X‐rays, respectively, in that were treated according a pathway. Results After the VAS score was reduced all...
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually June 15-29, 2020 with an attendance over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology contract research organizations, and regulatory agencies worldwide. WRIB included three Main Workshops, seven Specialized Workshops that together spanned 11 days order to allow exhaustive thorough coverage all major issues bioanalysis, biomarkers, immunogenicity, gene...
The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held 27 September to 1 October 2021. Even with a last-minute move from in-person virtual, an overwhelmingly high number nearly 900 professionals representing pharma and biotech companies, contract research organizations (CROs), multiple regulatory agencies still eagerly convened actively discuss most current topics interest bioanalysis. WRIB included three Main Workshops seven Specialized that together spanned...
Signal transducer and activator of transcription 3 (STAT3) is a factor that involved in variety biological functions. It essential for the signal transduction interleukin-6 (IL-6) related cytokines. In response to IL-6 stimulation STAT3 becomes phosphorylated translocates into nucleus where it binds enhancer sequences target genes. We found activated enriched dot-like structures within nucleus, which we termed nuclear bodies. To examine dynamics body formation, fusion protein yellow...
Interleukin-6 (IL-6) is a potent stimulator of bone resorption which has been demonstrated in variety vivo and vitro models. We investigated the regulation IL-6 secretion primary human osteoblastic cells (HOC) by cytokines known to play an important role coupling formation resorption. HOC were isolated from healthy adults who underwent selective orthopedic surgery treated with released microenvironment during i.e Interleukin-1 β (IL-lβ), Tumor Necrosis Factor (TNFa), Transforming Growth 1 2...