A5039745785- Fatigue and fracture mechanics
- Engineering and Materials Science Studies
- High Temperature Alloys and Creep
- Metal Alloys Wear and Properties
- Metal and Thin Film Mechanics
- High-Temperature Coating Behaviors
- Mechanical Failure Analysis and Simulation
- Hydrogen embrittlement and corrosion behaviors in metals
- Corrosion Behavior and Inhibition
- Parkinson's Disease Mechanisms and Treatments
- Additive Manufacturing Materials and Processes
- Aluminum Alloy Microstructure Properties
- Civil and Structural Engineering Research
- Aluminum Alloys Composites Properties
- Microstructure and Mechanical Properties of Steels
- Mechanical stress and fatigue analysis
- Engineering Structural Analysis Methods
- Metallurgy and Material Forming
- High Entropy Alloys Studies
- Advanced ceramic materials synthesis
- Physics and Engineering Research Articles
- Structural Analysis of Composite Materials
- Material Properties and Applications
- Fire effects on concrete materials
- Non-Destructive Testing Techniques
Technical University of Darmstadt
2016-2025
Institut Wohnen und Umwelt
2014-2023
Rehaklinik Zihlschlacht
2012-2021
Materials Technology (United Kingdom)
2018-2021
Materials Science & Engineering
2015-2017
Springer Nature (Germany)
2016
Kerckhoff Klinik
2004-2012
German Center for Neurodegenerative Diseases
2012
Innsbruck Medical University
2012
University of Bonn
2012
According to the basal ganglia-thalamocortical circuit model, dopamine depletion in nigrostriatal system leads hypoactivation supplementary motor area (SMA) and primary cortex (M1) Parkinson's disease. This functional cortical deafferentation its reversibility by levodopa (L-dopa) treatment has been established previous studies for SMA but remains controversial M1. We used MRI (fMRI) a simple finger opposition task correlate blood oxygenation level-dependent (BOLD) signal changes with...
Abstract McLeod syndrome is caused by mutations of XK , an X‐chromosomal gene unknown function. Originally defined as a peculiar Kell blood group variant, the disease affects multiple organs, including nervous system, but certainly underdiagnosed. We analyzed and clinical findings 22 affected men, aged 27 to 72 years. Fifteen different were found, nine which novel, one eponymous case McLeod. Their common result predicted absence or truncation protein. All patients showed elevated levels...
Symptoms of Parkinson's disease (PD) progress despite optimized medical treatment. The present study investigated the effects a flexibility and relaxation programme, walking, Nordic walking (NW) on speed, stride length, length variability, Parkinson-specific disability (UPDRS), health-related quality life (PDQ 39). 90 PD patients were randomly allocated to 3 treatment groups. Patients participated in 6-month with exercise sessions per week, each lasting 70 min. Assessment after completion...
Biomarkers are required for the diagnosis and monitoring of disease progression in Parkinson (PD). To date, most studies have concentrated on α-synuclein (α-Syn), a protein involved pathogenesis, as potential biomarker, with inconsistent outcomes. Recently, naturally occurring autoantibodies against α-Syn (α-Syn-nAbs) been detected serum patients PD. They represent putative diagnostic marker PD.We established validated an ELISA to quantify α-Syn-nAbs samples. We analyzed samples from 62 PD,...
Mild cognitive impairment, especially executive dysfunction might occur early in the course of Parkinson's disease. Cognitive training is thought to improve performance. However, transfer improvements achieved paper and pencil tests into daily life has been difficult. The aim current study was investigate whether a multimodal rehabilitation programme including physical exercises be more successful than programmes without motor training. 240 PD-patients were included randomly allocated three...
Pain is a common nonmotor symptom in patients with Parkinson disease (PD) but the correct diagnosis of respective cause remains difficult because suitable tools are lacking, so far. We developed framework to differentiate PD- from non-PD-related pain and classify PD-related into 3 groups based on validated mechanistic descriptors (nociceptive, neuropathic, or nociplastic), which encompass all previously described PD types. Severity syndromes was scored by ratings intensity, frequency,...
Crack bifurcation was observed in laminar ceramic composites when cracks entered thin Al 2 O 3 layers sandwiched between thicker of Zr(12Ce)O . The contained a biaxial, residual, compressive stress ∼2 GPa developed due to differential contraction upon cooling from the processing temperature. were nearly free tensile stresses because they much than layers. fabricated by green tape and codensification method. Different specimens examine effect thickness layer on phenomena. Bar fractured...
Ornithine transcarbamylase deficiency is an X linked disorder and the most common inherited cause of hyperammonaemia. Fluctuating concentrations ammonia, glutamine, other excitotoxic amino acids result in a chronic or episodically recurring encephalopathy. A heterozygous female patient first presented with protein intolerance, attacks vomiting, signs mental retardation early childhood. At age 16 complex partial seizures occurred which were treated sodium valproate. Seven days after...
Abstract Die Einschraubtiefe und die Größe des Vorlochdurchmessers bestimmen neben dem Scherfestigkeitsverhältnis der eingesetzten Werkstoffe quasi‐statische Beanspruchbarkeit von Schraubenverbindungen mit gefurchtem Gewinde. Zur Validierung eines neuen Bewertungsansatzes zur Bestimmung erforderlichen Mindesteinschraubtiefe werden Auszugsversuche variierter Gewindeüberdeckung für verschiedene Gewindetypen Gewindegrößen durchgeführt. In Form Beanspruchbarkeitsverhältnisses perfekt...