A5066089674- Forensic Toxicology and Drug Analysis
- Prenatal Substance Exposure Effects
- Opioid Use Disorder Treatment
- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Pharmacological Effects and Assays
- Maternal Mental Health During Pregnancy and Postpartum
- Neurotransmitter Receptor Influence on Behavior
- Analytical Methods in Pharmaceuticals
- Neonatal Health and Biochemistry
- Poisoning and overdose treatments
- Biosimilars and Bioanalytical Methods
- Advanced Chemical Sensor Technologies
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Metabolomics and Mass Spectrometry Studies
- Hormonal and reproductive studies
- Neuroscience of respiration and sleep
- Pharmacogenetics and Drug Metabolism
- Water Treatment and Disinfection
- Biochemical effects in animals
- Bacillus and Francisella bacterial research
- Analytical chemistry methods development
Center for Drug Evaluation and Research
2016-2024
Quality Research
2019-2024
United States Food and Drug Administration
2019-2024
National Institute on Drug Abuse
2007-2012
National Institutes of Health
2008-2012
West Virginia University
2005-2007
In a sample of methadone-maintained breastfeeding women and matched group formula-feeding women, this study evaluated concentrations methadone in breast milk among maternal infant plasma both groups.Eight (dose: 50-105 mg/day), lactating provided blood specimens on days 1, 2, 3, 4, 14, 30 after delivery, at the times trough peak levels. Paired foremilk hindmilk were obtained each sampling time. Eight subjects samples same days. Infant for groups day 14. Urine toxicological screening between...
Attention-enhancing effects of nicotine appear to depend on the nature attentional function.Underlying neuroanatomical mechanisms, too, may vary depending function modulated.This functional magnetic resonance imaging study recorded blood oxygen level--dependent (BOLD) activity in minimally deprived smokers during tasks simple stimulus detection, selective attention, or divided attention after single-blind application a transdermal (21 mg) placebo patch.Smokers' performance condition was...
Buprenorphine is approved as pharmacotherapy for opioid dependence in nonpregnant patients multiple countries and currently under investigation pregnant women the United States Europe. This research evaluates disposition of buprenorphine, opiates, cocaine, metabolites five term placentas from a US cohort. Placenta matched meconium concentrations were compared, relationships among maternal buprenorphine dose, placenta concentrations, neonatal outcomes after controlled administration during...
Few investigations have used placenta as an alternative matrix to detect in utero drug exposure, despite its availability at the time of birth and large amount sample. Methadone-maintained opioid-dependent pregnant women provide a unique opportunity examine placental disposition methadone metabolite [2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP)], explore their correlations with maternal dose neonatal outcomes, test ability exposure illicit drugs.We calculated EDDP concentrations...
Objectives: The purpose was to explore methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) umbilical cord disposition, correlate with maternal dose neonatal outcomes, evaluate the window of drug detection in utero illicit exposure. Methods: Subjects comprised 19 opioid-dependent pregnant women from 2 clinical studies, one comparing buprenorphine pharmacotherapy for opioid-dependence treatment second examining monetary reinforcement schedules maintain abstinence....
The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held 27 September to 1 October 2021. Even with a last-minute move from in-person virtual, an overwhelmingly high number nearly 900 professionals representing pharma and biotech companies, contract research organizations (CROs), multiple regulatory agencies still eagerly convened actively discuss most current topics interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned week...
A validated method for quantifying methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, cocaine, benzoylecgonine, 6-acetylmorphine, morphine, and codeine in human placenta by liquid chromatography-ion trap mass spectrometry is described. Specimens (1 g) were homogenized subjected to solid-phase extraction. Chromatographic separation was performed on a Synergi Polar RP column with gradient of 0.1% formic acid acetonitrile. The linear from 10 2000 ng/g methadone 2.5 500 other...
Many cities have banned indoor smoking in public places. Thus, an updated recommendation for a breath carbon monoxide (CO) cut-off is needed that optimally determines status. We evaluated and compared the performance of CO semiquantitative cotinine immunoassay test strips (urine saliva NicAlert®) alone combination.
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually June 15-29, 2020 with an attendance over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology contract research organizations, and regulatory agencies worldwide. WRIB included three Main Workshops, seven Specialized Workshops that together spanned 11 days order to allow exhaustive thorough coverage all major issues bioanalysis, biomarkers, immunogenicity, gene...
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually June 15-29, 2020 with an attendance over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology contract research organizations, and regulatory agencies worldwide. WRIB included three Main Workshops, seven Specialized Workshops that together spanned 11 days order to allow exhaustive thorough coverage all major issues bioanalysis, biomarkers, immunogenicity, gene...
Abstract The COVID-19 pandemic has led to increased usage of hand sanitizer products by the public prevent spread and decrease likelihood acquiring disease. increase in demand also an number manufacturers. This work describes FDA’s Center for Drug Evaluation Research (CDER) laboratories efforts develop tests assess quality containing ethanol or isopropanol as primary active ingredient. were evaluated ingredient content determination 12 impurities listed FDA Hand Sanitizer Temporary Guidance,...
Buprenorphine is under investigation in the U.S. as pharmacotherapy for opioid-dependent pregnant women. and metabolites were quantified umbilical cord specimens from women receiving daily buprenorphine doses. Correlations between maternal dose, metabolite concentrations, neonatal outcomes investigated, well ability to identify heroin cocaine relapse during pregnancy. Umbilical concentrations compared those of matched plasma meconium. detected all cords, but itself was absent. Concentration...
A combination of crushed garlic (Allium sativum) and black cumin seeds (Nigelia has been used as a traditional remedy for urinary tract infections. In-vitro antimicrobial testing suggested that the mixture two spices in ratio 1:1 effects on both Staphylococcus aureus Escherichia coli species. Analyses extract by GC-MS well LC–MS & MS2 confirmed main components were allicin, γ-glutamyl-S-allylcysteine allicin transformed products such diallyldisulfide vinyldithiins. Components thymoquinone,...