A5003167445- Biosimilars and Bioanalytical Methods
- Protein purification and stability
- Seismic Performance and Analysis
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- HIV/AIDS drug development and treatment
- Structural Behavior of Reinforced Concrete
- Structural Response to Dynamic Loads
- Structural Engineering and Vibration Analysis
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Seismic and Structural Analysis of Tall Buildings
- Cancer therapeutics and mechanisms
- Analytical Chemistry and Chromatography
- Retinal Diseases and Treatments
- Complement system in diseases
- Synthesis and Biological Evaluation
- Advanced Proteomics Techniques and Applications
- Bone Tissue Engineering Materials
- Drug Transport and Resistance Mechanisms
- Cellular Mechanics and Interactions
- Earthquake and Tsunami Effects
- Structural Load-Bearing Analysis
Boehringer Ingelheim (United States)
2011-2025
Shantou University
2023-2025
Shantou University Medical College
2023-2025
ShanghaiTech University
2025
Guizhou University
2023
Collaborative Innovation Center of Chemistry for Energy Materials
2023
Xiamen University
2023
Sichuan Provincial Architectural Design and Research Institute (China)
2015
Boehringer Ingelheim (Germany)
2013-2014
China Architecture Design & Research Group (China)
2012-2013
The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place Miami, Florida with participation of over 600 professionals from pharmaceutical and biopharmaceutical companies, biotechnology contract research organizations regulatory agencies worldwide. It is once again a 5-day week long event – full immersion bioanalytical specifically designed to facilitate sharing, reviewing, discussing agreeing approaches address the most current issues interest bioanalysis. topics covered...
Background Esophageal cancer (EC) is a major global health issue characterized by high morbidity and mortality rates, with notably low five-year survival rate. Comprehensive analyses of the burden EC remain limited outdated, despite its significance. This study aimed to systematically assess trends esophageal across diverse populations. Methods Data on were collected from Global Burden Disease (GBD) 2021 study, including estimates incidence, mortality, disability-adjusted life years (DALYs),...
The 18th Workshop on Recent Issues in Bioanalysis (18th WRIB) took place San Antonio, TX, USA May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week allow an exhaustive thorough coverage all major issues bioanalysis biomarkers, immunogenicity, gene therapy, cell therapy...
The mechanical properties and physical confinement of the extracellular matrix (ECM) are crucial roles in regulating tumor growth progression. Extensive efforts have been dedicated to replicating characteristics tissue by developing two-dimensional (2D) three-dimensional (3D) vitro models. However, it remains a significant challenge modulate local microenvironment around specific cells according culture progress. In this study, we develop 3D platform for multicellular lung cancer spheroids...
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology contract research organizations, and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event – A Full Immersion Week including Biomarkers Immunogenicity. As usual, it is specifically designed facilitate sharing, reviewing, discussing agreeing approaches address the most...
The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held 27 September to 1 October 2021. Even with a last-minute move from in-person virtual, an overwhelmingly high number nearly 900 professionals representing pharma and biotech companies, contract research organizations (CROs), multiple regulatory agencies still eagerly convened actively discuss most current topics interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned week...
Quantitative assessment of seismic damage by using models has been proved feasible and effective in controlling the earthquake-induced structures. In this study, a modification is proposed for original Park-Ang model eliminating its non-normalization problem. The combination coefficient modified derived cyclic test results flexure-dominant RC members from database provided Pacific Earthquake Engineering Research Center author's own tests. An empirical formula developed through multivariable...
Therapeutic proteins and peptides have potential to elicit immune responses resulting in anti-drug antibodies that can pose problems for both patient safety product efficacy. During drug development immunogenicity is usually examined by risk-based approach along with specific strategies developing “fit-for-purpose” bioanalytical approaches. Enzyme-linked immunosorbent assays electrochemiluminescence immunoassays are the most widely used platform ADA detection due their high sensitivity...
The 16th Workshop on Recent Issues in Bioanalysis (16th WRIB) took place Atlanta, GA, USA September 26-30, 2022. Over 1000 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week order allow exhaustive thorough coverage all major issues bioanalysis, biomarkers, immunogenicity, gene therapy, cell therapy...
Abstract The past decades have witnessed a flourish of novel high‐rise structures throughout the world under requirement ceaselessly progressing architectural aesthetics, resulting in complex plan and elevation building. Shanghai International Design Center is such building with two towers different heights connected by trusses, structural system composed steel frame, reinforced concrete (RC) core wall shear walls. great irregularity elevation, according to Chinese code, necessitates...
1. The absorption, biotransformation and excretion of empagliflozin, an SGLT2 inhibitor, were evaluated in eight healthy subjects following a single 50 mg oral dose empagliflozin containing ∼100 µCi [14C]-empagliflozin.2. Radioactivity was rapidly absorbed, with plasma levels peaking 1 h post-dose. Total exposure lower blood versus plasma, consistent moderate (28.6–36.8%) red cell partitioning. Protein binding 80.3–86.2%.3. Most the radioactive recovered urine (54.4%) faeces (41.1%)....
BI-X, a therapeutic protein under development for the treatment of human ocular disease via intravitreal administration, binds to its targets and endogenous albumin in vitreous humor. A monkey pharmacokinetic (PK) study following BI-X administration was conducted measure drug levels plasma, humor, aqueous retina tissue at various timepoints post-dose. comprehensive bioanalytical approach implemented support this study. Five immunocapture-LC-MS/MS assays were developed qualified quantitating...
Seismic fragility was assessed for 72 RC moment-resisting frame building structures designed according to the current Chinese seismic design code buildings, taking into account uncertainty of structural material strength and earthquake ground motions. The site soil type, number stories, protection intensity were considered be main variables reference structures. Fragilities four damage levels, i.e., fully operational, repairable, collapse prevention, are developed in this study. global...
Hepatocytes provide an integrated model to study drug metabolism and disposition. As a result of loss polarity or significant decrease in the expression enzymes transporters, suspended sandwich-cultured hepatocytes have limitations determining hepatocellular concentrations. Underprediction extent glucuronidation is also concern for these hepatocyte models. Faldaprevir hepatitis C virus protease inhibitor late-stage development that has demonstrated liver enrichment vivo rat models based on...
The pharmacokinetic and metabolite profiles of the antiretroviral agent tipranavir (TPV), administered with ritonavir (RTV), in nine healthy male volunteers were characterized. Subjects received 500-mg TPV capsules 200-mg RTV twice daily for 6 days. They then a single oral dose 551 mg containing 90 microCi [(14)C]TPV 200 on day 7, followed by twice-daily doses unlabeled up to 20 Blood, urine, feces collected mass balance profiling. Metabolite profiling identification was performed using flow...
There is an increasing demand for quantitative data on metabolite exposure triggered by regulatory guidances. This contribution describes the accuracy of nanoelectrospray ionization mass spectrometry response drug compounds and their metabolites from biological matrices compared with radiometric quantification. a comprehensive investigation set real-life pharmaceutical in relevant such as urine, bile, feces plasma. The suggest that can be used semi-quantitation absence reference standards....
A refinement of protein LC-MS bioanalysis is to use predigestion immunoaffinity capture extract the drug from matrix prior digestion. Because their increased sensitivity, such hybrid assays have been successfully validated and applied a number clinical studies; however, they can also be subject potential interferences antidrug antibodies, circulating ligands or other components specific patient populations and/or dosed subjects. The purpose this paper describe validation experiments that...
In this study, a new seismic design method for directly and efficiently controlling damage to structural non-structural components of moment-resisting reinforced concrete (RC) frame buildings is developed. The global index, which considers the effect accumulative damage, inter-story drift ratio are applied as performance indexes components, respectively. As base method, model, determination strength demand, objectives first introduced. Then, detailed procedures presented. Finally, case...
The pharmacokinetics, mass balance, and metabolism of deleobuvir, a hepatitis C virus (HCV) polymerase inhibitor, were assessed in healthy subjects following single oral dose 800 mg [(14)C]deleobuvir (100 μCi). overall recovery radioactivity was 95.2%, with 95.1% recovered from feces. Deleobuvir had moderate to high clearance, the half-life deleobuvir plasma ∼ 3 h, indicating that there no metabolites half-lives significantly longer than parent. most frequently reported adverse events (in 6...
Half-life extension strategies to reduce the intravitreal dosing frequency of biomolecules for treatment retinal neovascular diseases are attracting increasing interest. This study investigated ocular and systemic pharmacokinetics trivalent nanobody BI-X (with affinity VEGF, Ang-2 human albumin) in cynomolgus monkeys after injection. concentrations were measured serial samples plasma, vitreous humor, aqueous humor retina. Ocular exhibited two phases. Initially up 2–4 weeks dosing, vitreal,...
ABSTRACT The pharmacokinetics, mass balance, and metabolite profiles of faldaprevir, a selective peptide-mimetic hepatitis C virus NS3/NS4 protease inhibitor, were assessed at steady state in 7 healthy male subjects. Subjects received oral doses 480 mg faldaprevir on day 1, followed by 240 days 2 to 8 10 15. [ 14 C]faldaprevir (240 containing 100 μCi) was administered 9. Blood, urine, feces, saliva samples collected intervals throughout the study. Metabolite profiling performed using...