A5032811645- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Mass Spectrometry Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chromatography in Natural Products
- Biosensors and Analytical Detection
- Biosimilars and Bioanalytical Methods
- Advanced Proteomics Techniques and Applications
- Blood groups and transfusion
- Protein purification and stability
- Thyroid Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Lipid metabolism and biosynthesis
- Pesticide Residue Analysis and Safety
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Chemical Reactions and Isotopes
- Clinical Laboratory Practices and Quality Control
Pfizer (United States)
2021-2025
Waters (United States)
2014-2020
The 17
The 18th Workshop on Recent Issues in Bioanalysis (18th WRIB) took place San Antonio, TX, USA May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week allow an exhaustive thorough coverage all major issues bioanalysis biomarkers, immunogenicity, gene therapy, cell therapy...
A balanced omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratio has been linked to health benefits and the prevention of many chronic diseases. Current dietary intervention studies with different sources omega-3 acids (omega-3) lack appropriate control diets carry other confounding factors derived from genetic environmental variability. In our study, we used fat-1 transgenic mouse model as a proxy for long-term supplementation determine, in well-controlled manner, molecular phenotype...
The 16th Workshop on Recent Issues in Bioanalysis (16th WRIB) took place Atlanta, GA, USA September 26-30, 2022. Over 1000 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week order allow exhaustive thorough coverage all major issues bioanalysis, biomarkers, immunogenicity, gene therapy, cell therapy...
The desire to reach ever-diminishing lower limits of quantification (LLOQ) probe changes in low abundance protein targets has led enormous progress sample preparation and liquid chromatography–tandem mass spectrometry (LC-MS/MS) instrumentation. To maximize signal reduce noise, many approaches have been employed, including specific immunoaffinity (IA) enrichment reducing the LC flow nanoflow (nLC) level; however, additional sensitivity gains may still be required. Recently, a technique...
Increased pressure to obtain more, higher sensitivity data from less sample is especially critical for large peptides, whose already optimized LC-MS methods are heavily challenged by traditional ligand-binding assays.Critical bioanalytical assays were adapted integrated microscale LC reduce volumes while increasing sensitivity. Assays teriparatide, glucagon and human insulin five analogs transferred 2.1 mm analytical scale a 150 µm system. This resulted in 15-30 fold overall improvement...
In this paper, high throughput analysis with 3 minute, rapid gradient conditions is described using the ionKey/MS™ System an integrated ACQUITY UPLC® M-Class and Xevo® G2-XS QTof Mass Spectrometer. Extensive testing of representative small molecules a peptide shows that system well-tolerated exhibits excellent reproducibility linear response. The iKey™ HSS T3 Separation Device used robust, withstanding ~2200 injections prepared human plasma peak shape pressure profile. A 99% solvent savings...
Quantitative modeling is increasingly utilized in the drug discovery and development process, from initial stages of target selection, through clinical studies. The can provide guidance on three major questions-is this right target, what are compound properties, dose for moving best possible candidate forward. In manuscript, we present a site-of-action framework which apply to monoclonal antibodies against soluble targets. We give comprehensive overview how construct model parametrize it...