A5046879189- Virus-based gene therapy research
- Biosimilars and Bioanalytical Methods
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Virology and Viral Diseases
- Pharmaceutical studies and practices
- Non-Destructive Testing Techniques
- Force Microscopy Techniques and Applications
- Viral Infections and Outbreaks Research
- CRISPR and Genetic Engineering
- Advanced Proteomics Techniques and Applications
- Advanced Electron Microscopy Techniques and Applications
- Biomedical and Engineering Education
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- interferon and immune responses
Boehringer Ingelheim (United States)
2022-2025
Regeneron (United States)
2025
Boehringer Ingelheim (Germany)
2022
Vesicular stomatitis virus expressing the glycoprotein of lymphocytic choriomeningitis (VSV-GP) is a promising platform for oncolytic viruses and cancer vaccines. In this work, cryoelectron microscopy (cryo-EM) imaging was employed to directly visualize VSV-GP particles. Several different subpopulations particle morphology were observed. Definition fraction counting enabled quantitative comparison subpopulation profiles between several samples. developing an orthogonal method with higher...
The 17th Workshop on Recent Issues in Bioanalysis (17th WRIB) took place Orlando, FL, USA June 19–23, 2023. Over 1000 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week allow an exhaustive thorough coverage all major issues bioanalysis biomarkers, immunogenicity, gene therapy, cell therapy vaccines....
The 18th Workshop on Recent Issues in Bioanalysis (18th WRIB) took place San Antonio, TX, USA May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week allow an exhaustive thorough coverage all major issues bioanalysis biomarkers, immunogenicity, gene therapy, cell therapy...
Replication-competent oncolytic virus (OV) therapies are a promising new modality for cancer treatment. However, they pose unique challenges preclinical assessment, due in part to their tumor specificity and ability self-replicate vivo. Understanding biodistribution, immune cell responses, potential effects of intratumoral replication on these outcomes important aspects the nonclinical profile OVs. Herein, single intravenous dose vesicular stomatitis pseudotyped with glycoprotein lymphocytic...
Therapeutic oligonucleotides (ONs) have characteristics of both small molecules and biologics. Although safety assessment ONs largely follows guidelines established for molecules, the unique often require incorporation concepts from The immunogenicity ON therapeutics is one area where approach distinct either molecule or biologic platforms. Information regarding limited, but indicates that administration can result in antidrug antibody formation. In this study, we summarize collective...
The rapidly developing field of oncolytic virus (OV) therapy necessitates the development new and improved analytical approaches for characterization during production development. Accurate monitoring absolute quantification viral proteins are crucial OV product can facilitate understanding infection, immunogenicity, stages replication. Targeted mass spectrometry methods like multiple reaction (MRM) offer a robust way to directly detect quantify specific targeted represented by surrogate...