A5025509670- Wood and Agarwood Research
- Biosimilars and Bioanalytical Methods
- Pesticide Residue Analysis and Safety
- Plant biochemistry and biosynthesis
- Antibiotics Pharmacokinetics and Efficacy
- Microbial Metabolism and Applications
- Cultural Heritage Materials Analysis
- Biological Stains and Phytochemicals
- Traditional Chinese Medicine Analysis
- Mass Spectrometry Techniques and Applications
- Remote Sensing and Land Use
- Forest ecology and management
- Analytical chemistry methods development
- Plant Gene Expression Analysis
- Metabolomics and Mass Spectrometry Studies
- Forest, Soil, and Plant Ecology in China
- Chromatography in Natural Products
- Protein purification and stability
- Biosensors and Analytical Detection
- Soil Carbon and Nitrogen Dynamics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Traditional and Medicinal Uses of Annonaceae
- Clinical Laboratory Practices and Quality Control
- Electrodeposition and Electroless Coatings
- Viral Infectious Diseases and Gene Expression in Insects
Guangxi University
2008-2024
Novartis (United States)
2017-2024
GTx (United States)
2019-2020
Institute of Modern Physics
2009-2016
Fudan University
2009-2016
Tris Pharma (United States)
2016
Shijiazhuang Tiedao University
2014
Bristol-Myers Squibb (Germany)
2014
Novartis (Switzerland)
2013
National Central University
2012-2013
Abstract This first‐in‐human study evaluated the safety, tolerability, single‐ and multiple‐dose pharmacokinetic profiles with dietary influence, pharmacodynamics (PD) of DFV890, an oral NLRP3 inhibitor, in healthy participants. In total, 122 participants were enrolled into a three‐part trial including single 2‐week multiple ascending doses (SAD MAD, respectively) randomized (3:1) to DFV890 or placebo [3–600 mg] MAD [fasted: 10–200 mg, once‐daily fed: 25 50 twice‐daily]). was generally...
The 17
The gas-phase acidity and proton affinity of thymine, cytosine, 1-methyl cytosine have been examined using both theoretical (B3LYP/6-31+G*) experimental (bracketing, Cooks kinetic) methods. This paper represents a comprehensive examination multiple acidic sites thymine the cytosine. Thymine exists as most stable "canonical" tautomer in gas phase, with ΔHacid 335 ± 4 kcal mol−1 (ΔGacid = 328 mol−1) for more N1−H. less N3−H site has not, heretofore, measured; we bracket value 346 3 339 mol−1)....
Continuous innovation in artificially-induced agarwood technology is increasing the amount of and substantially alleviating shortages. Agarwood widely utilized perfumes fragrances; however, it unclear whether overall pharmacological activity induced can replace wild for medicinal use. In this study, volatile components, total chromone content, differences activities agarwood, including antioxidant, anti-acetylcholinesterase, anti-glucosidase were all determined. The results indicated that...
The <i>UGT1A1*28</i> polymorphism is known to correlate with altered clearance of bilirubin (Gilbert syndrome) and drugs such as 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin (CPT-11). Although this clinically relevant leads significant drug-related toxicity CPT-11, in vitro tools allow prediction how it will affect the new chemical entities have not been completely developed. To a more complete assessment whether be affected by UGT1A1*28 polymorphism, panel microsomes...
A differential mobility spectrometry (DMS) in combination with a multiple ion monitoring (MIM) method was developed and validated for quantitative LC-MS/MS bioanalysis of pasireotide (SOM230) human plasma. Pasireotide, therapeutic cyclic peptide, exhibits poor collision-induced dissociation (CID) efficiency reaction (MRM) detection. Therefore, an effort to increase the overall sensitivity assay, DMS-MIM approach explored. By selecting most abundant doubly charged precursor both Q1 Q3 mass...
Biochar is important for soil improvement, fertilizer innovation, and greenhouse gas reduction. In this paper, Mg-modified biochar was prepared from rice corn straw mixed with at a 1% (w/w) addition in an indoor simulation experiment to study the effect of on chemical properties acidic soil. The results showed that reduced acidity improved fertility. Compared control group, treatment significantly increased concentrations available potassium, phosphorus, total organic carbon exchangeable...
The 16th Workshop on Recent Issues in Bioanalysis (16th WRIB) took place Atlanta, GA, USA September 26-30, 2022. Over 1000 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week order allow exhaustive thorough coverage all major issues bioanalysis, biomarkers, immunogenicity, gene therapy, cell therapy...
Currently, the planting of ‘Qi-Nan’ is continuously increasing, yet a substantial amount leaves have not been properly exploited. To improve tree ’s utilization value, were used as raw material. An ultrasound-assisted method was performed to obtain flavonoids from ’Qi-Nan’ leaves, followed by optimization extraction factors using one-way and response surface methodology enhance flavonoids. Subsequently, composition flavonoids, well their bioactive abilities, analyzed ultra-high-performance...
Activated carbon fiber was prepared from liquefied wood by chemical activation with ZnCl2 (Z-LWACF) at different impregnation ratios, a particular focus on its adsorption property, kinetic and isotherm. The characterization properties of Z-LWACFs were investigated nitrogen adsorption/desorption, X-ray photoelectron spectroscopy (XPS), methylene blue (MB) iodine adsorption. Two process methods employed to prepare Z-LWACF contrasted others fibers. results showed that the obtained one-step...
In this study, we analyzed the mechanism and process of fungal-induced agarwood formation in Aquilaria sinensis studied functional changes xylem structure after process. The microscopic white zone, transition decay zone 12-and 18-months inoculation A. was studied. distribution nuclei, starch grains, soluble sugars, sesquiterpenes, fungal propagules, mycelium tissues investigated by histochemical analysis. results show that accompanied apoptosis parenchyma cells such as interxylary phloem,...
The wood of Michelia macclurei Dandy (MD) is an excellent material that widely used in the furniture, handicraft, and construction industries. However, less research has been conducted on chemical composition biological activity heartwood, which main valuable part wood. This study aimed to investigate activities heartwood (MDHW) confirm active ingredients. Triple quadrupole gas chromatography-mass spectrometry (GC-MS) was characterize volatile components MDHW, while ultra-performance liquid...
An LC-MS/MS-based approach that employs authentic radioactive metabolites as reference standards was developed to estimate metabolite exposures in early drug development studies. This method is useful levels studies done with non-radiolabeled compounds where are not available allow standard LC-MS/MS assay development. A mixture obtained from an vivo source treated a radiolabeled compound partially purified, quantified, and spiked into human plasma provide curves. Metabolites were analyzed by...
The formation of a tree's heartwood gives the wood properties such as natural decay resistance and aesthetic color, often directly determines value products. Regulating quantity quality is great importance to use wood. However, mechanism has been poorly understood.Using Dalbergia odorifera study species, number starch grains, morphology nuclei, changes in content water secondary metabolites were observed continuously radial direction xylem. results show that from outer toward inner sapwood,...
A sapwood tree is a species in which the does not differ significantly from heartwood and cannot be classified by shades of color. It generally accepted that has higher economic value than sapwood, but most studies related to formation have focused on trees, with less research trees. In this paper, we take Schima superba as object analyze physiological biochemical changes process studying anatomical structure parenchyma cells, then further explore main categories metabolites compositional...
Heartwood has a high economic value because of its natural durability, beautiful color, special aroma, and richness in active ingredients used traditional Chinese medicine. However, the mechanism heartwood formation remains unclear. Dalbergia odorifera was selected as object research to analyze this variation chemical composition sapwood, transition zone, well elucidate relationship between heartwood. The secondary metabolites analyzed using gas chromatography-mass spectrometry ultra-high...