A5071341366- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Tea Polyphenols and Effects
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Food Quality and Safety Studies
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Phytochemicals and Antioxidant Activities
- Enzyme Structure and Function
- Traditional Chinese Medicine Analysis
- Plant and Fungal Interactions Research
- Microbial Natural Products and Biosynthesis
- Fatty Acid Research and Health
- Plant Pathogenic Bacteria Studies
- Advancements in Transdermal Drug Delivery
- Fermentation and Sensory Analysis
- Algal biology and biofuel production
- Microbial Metabolism and Applications
- Nanocomposite Films for Food Packaging
- Animal health and immunology
- Plant Parasitism and Resistance
- Vibrio bacteria research studies
- Antimicrobial Peptides and Activities
- Ginseng Biological Effects and Applications
Guangxi University
2012-2024
Northwest A&F University
2024
Ministry of Agriculture and Rural Affairs
2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2014-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2022
Institute of Subtropical Agriculture
2022
AgroBio
2022
Guangxi Medical University
2022
Russula vinosa Lindbl (RVL) is a multifunctional edible fungus that has recently gained widespread attention due to its numerous nutritious, delicious, and medicinal properties. However, little been directed toward analyzing comprehensive phytochemical profiling bioactivity in RVL. This study aimed evaluate the of RVL systematically. Herein, we characterized global using LC/GC-MS-based multiomics strategy through initial methodological optimization. A total 633 metabolites were identified...
Non-alcoholic fatty liver disease (NAFLD) poses a significant global public health concern. Liupao tea (LPT) is Chinese national geographical indication product renowned for its lipid-lowering properties. However, the precise mechanisms and active constituents contributing to efficacy of LPT against NAFLD remain unclear.
Colorectal adenoma (CA) is an important precancerous lesion and early screening target of colorectal cancer (CRC). Lipids with numerous physiological functions are proved to be involved in the development CRC. However, there no lipidomic study large-scale serum samples on diagnostic biomarkers for CA.The lipidomics CA patients (n = 50) normal control (NR) was performed by ultra high performance liquid chromatography-high resolution mass spectrometry electrospray ionization (UHPLC-ESI-HRMS)....
Abstract Background Understanding the metabolic changes in colorectal cancer (CRC) and exploring potential diagnostic biomarkers is crucial for elucidating its pathogenesis reducing mortality. Cancer cells are typically derived from tissues can be easily obtained cultured. Systematic studies on CRC at different stages still lacking. Additionally, there a need to validate our previous findings human serum. Methods Ultrahigh-performance liquid chromatography tandem high-resolution mass...
Tank fermentation is a novel technology; however, the role of microorganisms in Liupao tea quality unknown. Using high-throughput sequencing, untargeted metabolomics, and targeted absolute quantification, microbial community, chemical profile, metabolites, metabolic pathway were discovered. Sphingomonas, Aquabacterium, Wolbachia, Blastobotrys, Aspergillus, Rasamsonia, Candida found to be most common microorganisms, throughout fermentation, Blastobotrys was dominant fungal genus. A total 40...
Astaxanthin (AST), a red pigment of the carotenoids, has various advantageous biological activities. Nevertheless, wide application AST is restricted due to its poor water solubility and highly unsaturated structure. To overcome these limitations, carrier-free astaxanthin nanoparticles (AST-NPs) were fabricated through anti-solvent precipitation method. The AST-NPs had small particle size, negative zeta potential high loading capacity. Analysis DSC XRD demonstrated that amorphous existed in...
Summary Baking treatment is commonly used to improve the aroma and taste of tea but its effects on Liupao are unknown. The quality, nonvolatile volatile compounds stale‐aroma type (CX) baked (HB) were investigated. After baking, bitterness aftertaste‐bitterness infusion reduced, grass was increased, stale weakened. Caffeine, (−)‐epigallocatechin, (−)‐epigallocatechin gallate, (−)‐epicatechin gallic acid content decreased significantly. Significant lipid down‐regulation observed in...
Abstract Salicylic acid (SA) plays a crucial role in plant defense against biotrophic and semibiotrophic pathogens. In Arabidopsis (Arabidopsis thaliana), isochorismate synthase 1 (AtICS1) is key enzyme for the pathogen-induced biosynthesis of SA via catalytic conversion chorismate into isochorismate, an essential precursor synthesis. Despite extensive knowledge ICS1-related menaquinone, siderophore, tryptophan (MST) enzymes bacteria, structural mechanisms substrate binding catalysis (ICS)...
Abstract Background Lonicera japonica Flos is widely used as a medicinal plant in China owing to its various pharmacological activities. However, little known about the metabolic profile and antibacterial properties of leaves species. The present study aimed determine compare metabolite profiles antioxidant activities leaf extracts five Results 598 metabolites were identified based metabolomics using UHPLC-Q Exactive Orbitrap MS/MS species leaves. Among them, flavonoids phenols compounds...
As a key precancerous lesion, colorectal advanced adenoma (CAA) is closely related to the occurrence and development of cancer (CRC). Effective identification CAA-related biomarkers can prevent CRC morbidity mortality. Lipids, as an important endogenous substance, have been proved be involved in CRC. Lipidomics technique that studies lipid metabolism diseases. However, there are no lipidomics based on large serum samples explore diagnostic for CAA.An integrated profile from 50 normal (NR) 46...
The development of a colorectal adenoma (CA) into carcinoma (CRC) is long and stealthy process. There remains lack reliable biomarkers to distinguish CA from CRC. To effectively explore underlying molecular mechanisms identify novel lipid promising for early diagnosis CRC, an ultrahigh-performance liquid chromatography tandem high-resolution mass spectrometry (UHPLC-HRMS) method was employed comprehensively measure species in human serum samples patients with Results showed significant...
Curcumin (Cur), a natural hydrophobic polyphenolic compound, exhibits multiple beneficial biological activities. However, low water solubility and relative instability hinder its application in food fields. In this study, carrier-free curcumin nanoparticles (CFC NPs) were prepared by adding the DMSO solution of Cur into DI under continuous rapid stirring. The morphology CFC NPs was spherical shape with diameter 65.25 ± 2.09 nm (PDI = 0.229 0.107), loading capacity (LC) as high 96.68 0.03%....
A photovoltaic reactor was designed for artificial photosynthesis, based on the reactions involved in high energy hydrogen atoms, which were produced from water electrolysis. Water and CO2, under conditions studied, converted to oxalate (H2C2O4) a polymer. This first time that oxalates oxalate-based polymer photosynthesis process.
Ethnopharmacological relevance: Hyperlipidemia as a major health issue has attracted much public attention. As geographical indication product of China, Liupao tea (LPT) is typical representative traditional Chinese dark that shown good potential in regulating glucose and lipid metabolism. LPT important medicinal value hyperlipidemia prevention. However, the active ingredients metabolic mechanisms by which alleviates remain unclear.Aim study: This study aimed to systematically investigate...
Abstract Background Understanding the metabolic changes in colorectal cancer (CRC) is crucial for elucidating its pathogenesis and early monitoring, thereby reducing mortality. However, there a lack of systematic research on differences CRC cells at different stages. Furthermore, studies validating multiomics findings serum patients using cell models have not yet been published. Methods Ultrahigh-performance liquid chromatography tandem high-resolution mass spectrometry (UHPLC-HRMS)-based...
Liupao tea (LPT) is a Chinese dark known to possess unique flavour. Microbial fermentation plays crucial role in flavour development and enrichment. Currently, the phytochemical profiles bioactivities of LPT with without are not fully known. In this study, we compared chemical composition raw (SF), stale-aroma (SA), betelnut-aroma (BA) type through application GC/LC-MS-based metabolomics, experimentally investigated their
Inoculating zinc solubilizing microorganisms (ZSMs) is considered as a promising strategy for increasing Zn phytoavailability in soils with low availability. In present study, we screened six strains of ZSMs from rhizosphere green manure crop, including three fungi,