A5026985361- Sperm and Testicular Function
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Heat shock proteins research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- CRISPR and Genetic Engineering
- Pancreatitis Pathology and Treatment
- Bone Metabolism and Diseases
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cellular Mechanics and Interactions
- Plant and Fungal Interactions Research
China National Rice Research Institute
2015-2025
Henan Cancer Hospital
2014-2024
Zhengzhou University
2014-2024
Guangxi University
2015-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2016-2024
BitPlus (United States)
2024
Ligand Pharmaceuticals (United States)
2024
Next Generation Technology (United States)
2024
Check Point (Israel)
2024
Eastern Cooperative Oncology Group
2024
Background: The addition of immune checkpoint inhibitors to neoadjuvant chemotherapy in operable advanced gastric or gastroesophageal junction (G/GEJ) cancer aroused wide interest. This study was designed assess the efficacy and safety sintilimab, a programmed cell death protein-1 (PD-1) inhibitor, combination with fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT) for HER2-negative locally G/GEJ cancer. Methods: Eligible patients clinical stage cT4 and/or cN+M0 were enroled this phase...
High rate of glycolysis supports hepatocellular carcinoma (HCC) cell growth even in a hypoxic environment. However, the mechanism underlying under hypoxia remains largely unknown. Long noncoding RNAs (lncRNAs) play essential roles regulating glucose metabolism cancers. This study aimed to explore role lncRNA homeobox transcript antisense RNA (HOTAIR) HCC hypoxia. Thirty-eight patients were recruited. HepG2 and Huh7 cells used for vitro. The expression levels HOTAIR, microRNA-130a-3p...
Spermatogenesis carries the task of precise intergenerational transmission genetic information from paternal genome and involves complex developmental processes regulated by testicular microenvironment. Studies performed mainly in mouse models have established theoretical basis for spermatogenesis, yet wide interspecies differences preclude direct translation findings, farm animal studies are progressing slowly. More than 32,000 cells prepubertal (3-month-old) pubertal (24-month-old) buffalo...
Chemoresistance is a major obstacle to cancer therapy including that of colon (CC). Although the dysregulation many miRNAs has been implicated in 5-fluorouracil (5-FU) resistance CC cells, specific role miR-20b chemoresistance not documented. In present study, we first determined expression by RT-PCR and levels disintegrin metalloprotease 9 (ADAM9) epidermal growth factor receptor (EGFR) western blotting adjacent non-cancerous tissues from 5-FU-sensitive or -resistant patients. Subsequently,...
Exosomes are nanosized membranous vesicles secreted by various types of cells, which facilitate intercellular communication transporting bioactive compounds. abundant in biological fluids including semen, and their protein composition the potential seminal plasma exosomes (SPEs) as fertility biomarkers were elucidated humans, however, little information is available regarding buffalo (Bubalus bubalis). Here, we examined correlation between spermatozoa, (SP), SPEs, compared analyzed...
Abstract Background Accumulating studies have demonstrated that the Warburg effect plays a central role in occurrence and development of hepatocellular carcinoma (HCC), albeit non-coding RNA (lncRNA) its association remains unclear. Methods The Zhengzhou University People’s Hospital kindly provided 80 pairs HCC tissues their matched paracancerous for this study. Bioinformatics analysis, real-time quantitative polymerase chain reaction, Western blotting, oncology functional assays were...
Follicular fluid (FF) accumulates in the antrum of ovarian follicle and provides microenvironment for oocyte development. FF plays an important role growth maturation. The a unique window to investigate processes occurring during buffalo follicular observed low quality oocytes may arise from poor microenvironment. Investigating proteins found (BFF) should provide insight into development further understanding intra-follicular maturation quality. Here, proteomic-based approach was used...
The rapid production and release of a large number inflammatory cytokines can cause excessive local systemic inflammation in severe acute pancreatitis (SAP) multiple organ dysfunction syndrome (MODS), especially pancreatitis-associated lung injury (P-ALI), which is the main early death patients with SAP. NLRP3 inflammasome plays an important role maturation IL-1β cascade. Here, we established model SAP using wild-type (NLRP3+/+) knockout (NLRP3-/-) mice by intraperitoneal injections...
Circular RNAs (circRNAs) play important roles in the development and progression of various human cancers. hsa-circ-0046600 is a circRNA unknown function. The purpose this study was to investigate biological function hepatocellular carcinoma (HCC) elucidate possible molecular mechanisms circRNA.GSE97332, quantitative reverse transcription polymerase chain reaction (qRT-PCR) fluorescence situ hybridization (FISH) were used detect expression HCC tissues cells. A dual-luciferase reporter assay...
The receptor-like kinase FLAGELLIN-SENSITIVE 2 (FLS2) functions as a bacterial flagellin receptor localized on the cell membrane of plants. In Arabidopsis, co-receptor BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1) cooperates with FLS2 to detect epitope flg22, resulting in formation signaling complex that triggers plant defense responses. However, responsible for recognizing and flg22 rice remains undetermined, precise structural mechanism underlying FLS2-mediated signal activation transduction...
Glioma is the most frequent primary cerebral tumor in adults. Recent evidence has suggested that circular RNAs (circRNAs) are associated with pathological processes glioma. In our study, we aimed to investigate function and mechanism of circ_CAPG (circ_0055412) Firstly, circ_0055412 expression was examined through RT-qPCR analysis. Loss-of-function assays animal experiments were implemented evaluate role on cisplatin resistance glioma cells. Moreover, done probe into regulatory Circ_0055412...
Abstract Salicylic acid (SA) plays a crucial role in plant defense against biotrophic and semibiotrophic pathogens. In Arabidopsis (Arabidopsis thaliana), isochorismate synthase 1 (AtICS1) is key enzyme for the pathogen-induced biosynthesis of SA via catalytic conversion chorismate into isochorismate, an essential precursor synthesis. Despite extensive knowledge ICS1-related menaquinone, siderophore, tryptophan (MST) enzymes bacteria, structural mechanisms substrate binding catalysis (ICS)...
On May 15, 2021, China’s first Mars exploration mission, Tianwen-1 (TW-1), successfully landed its Zhurong rover in the southern Utopia Planitia on Mars. Pitted cones, a characteristic feature of both and landing area, play pivotal role understanding local geological processes. We conducted detailed investigation into spatial distribution, morphological characteristics, morphometric parameters these cones to uncover their origins. Using High-Resolution Imaging Camera images...
The brown planthopper (BPH) is one of the major rice pests causing significant damage to production worldwide, due its high reproductive capacity and strong migratory ability. A series BPH-resistant varieties have been developed, but durability effective resistance constrained by evolution BPH virulence, requiring in-depth insights into mechanisms. In this paper, we used strand-specific lncRNA-seq characterize lncRNA regulatory mechanisms on response infestation. Overall, 4321 lncRNAs were...
Contents This study was undertaken to investigate differences in protein expression between high‐ and low‐motility sperm of swamp buffalo. The research used two‐dimensional gel electrophoresis (2 DE ) coupled matrix‐assisted laser desorption/ionization time‐of‐flight tandem mass spectrometry ( MALDI ‐ TOF / MS analyse the different proteins. results showed 18 spots buffalo sperm; eight these proteins were up‐regulated sperm, five down‐regulated, one deleted four specifically expressed....
Glioblastoma (GBM) is an aggressive and malignant brain tumor with extremely poor prognosis. Despite advances in treatment, the pathogenesis of GBM remains elusive. Mounting studies have revealed critical role circular RNAs (circRNAs) development progression human cancers including GBM, but comprehension their functions still insufficient. In this study, we investigated expression profile a circRNA derived from GLIS family zinc finger 3 (GLIS3) normal astrocytes. CircGLIS3 was detected...
To investigate the expression of miR-29a in rat acute pancreatitis and its functional role AR42J cell apoptosis.Twelve SD rats were divided into a control group an edematous (AEP) randomly. AEP was induced by intraperitoneal injection L-arginine (150 mg/kg) equal volume 0.9% NaCl injected group. The apoptosis acinar cells pancreatic tissue determined TUNEL assay. miRNA chip assay performed to examine miRNAs two groups. Besides, further explore vitro, recombinant TNF-α (50 ng/mL) administered...