A5033129879- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Connective tissue disorders research
- Hip and Femur Fractures
- Bone and Dental Protein Studies
- Pelvic and Acetabular Injuries
- TGF-β signaling in diseases
- Bone health and osteoporosis research
- Management of metastatic bone disease
- Protease and Inhibitor Mechanisms
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Parathyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Thyroid and Parathyroid Surgery
- Exercise and Physiological Responses
- Nuclear Structure and Function
- Growth Hormone and Insulin-like Growth Factors
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2023
TU Dresden
2022-2023
University Hospital Carl Gustav Carus
2022-2023
Baylor College of Medicine
2011-2021
Heidelberg University
2004-2013
University Hospital Heidelberg
2005-2010
Heidelberger Institut für Radioonkologie
2007
Heidelberg University
2005
Abstract This study investigates the effects of kyphoplasty on pain and mobility in patients with osteoporosis painful vertebral fractures compared conventional medical management. Introduction: Pharmacological treatment primary does not prevent impaired activity fractures. Therefore, we evaluated clinical outcome after associated chronic for >12 months. Materials Methods: Sixty presenting months were included this prospective, nonrandomized controlled study. Twenty-four hours before...
Osteogenesis imperfecta (OI) is a spectrum of genetic disorders characterized by bone fragility. It caused dominant mutations affecting the synthesis and/or structure type I procollagen or recessively inherited in genes responsible for posttranslational processing/trafficking procollagen. Recessive OI VI unique among types that it an increased amount unmineralized osteoid, thereby suggesting distinct disease mechanism. In large consanguineous family with VI, we performed homozygosity mapping...
BACKGROUNDCurrently, there is no disease-specific therapy for osteogenesis imperfecta (OI). Preclinical studies demonstrate that excessive TGF-β signaling a pathogenic mechanism in OI. Here, we evaluated children with OI and conducted phase I clinical trial of inhibition adults OI.METHODSHistology RNA-Seq were performed on bones obtained from children. Gene Ontology (GO) enrichment assay, gene set analysis (GSEA), Ingenuity Pathway Analysis (IPA) used to identify dysregulated pathways....
In Brief Study Design. A comparative prospective trial evaluating 3-year outcome. Objective. To compare clinical and morphologic outcomes as well follow-up fractures after kyphoplasty of painful osteoporotic vertebral with calcium-phosphate (CaP) cement (group 1) polymethylmethacrylate (PMMA)-cement 2). Summary Background Data. CaP cements seem to be an alternative material for usage in fractures. are biodegradable replaceable by newly formed bone implantation. Concerns have been raised...
ABSTRACT Osteogenesis imperfecta (OI) is characterized by low bone mass, poor quality, and fractures. Standard treatment for OI patients limited to bisphosphonates, which only incompletely correct the phenotype, seem be less effective in adults. Sclerostin-neutralizing antibodies (Scl-Ab) have been shown beneficial animal models of osteoporosis, dominant resulting from mutations genes encoding type I collagen. However, Scl-Ab has not studied recessive OI. Cartilage-associated protein (CRTAP)...
Abstract Background Calcium phosphate cements are used frequently in orthopedic and dental surgeries. Strontium-containing drugs serve as systemic osteoblast-activating medication various clinical settings promoting mechanical stability of the osteoporotic bone. Methods calcium cement (SPC) (CPC) were compared regarding their local effects on bone tissue a standard animal model for A defect was created distal femoral metaphysis 60 ovariectomized Sprague-Dawley rats. CPC SPC to fill defects...
Pulmonary complications are a significant cause for morbidity and mortality in osteogenesis imperfecta (OI). However, to date, there have been few studies that systematically evaluated pulmonary function individuals with OI. We analyzed spirometry measurements, including forced vital capacity (FVC) expiratory volume the first second (FEV1 ), large cohort of OI (n = 217) enrolled multicenter, observational study. show more severe form disease, type III, significantly reduced FVC FEV1 which do...
Abstract Background This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only. Methods We assessed pain, disability parameters by visual analogue scale (VAS 0‐100), Oswestry Disability Index re‐evaluating available follow‐up X‐rays, respectively, in that were treated according a pathway. Results After the VAS score was reduced all...
TGF-β is abundantly produced in the skeletal system and plays a crucial role homeostasis. E-selectin ligand-1 (ESL-1), Golgi apparatus-localized protein, acts as negative regulator of bioavailability by attenuating maturation pro–TGF-β during cartilage However, whether regulation intracellular ESL-1 also bone homeostasis has not been well defined. Here, we show that Esl-1 −/− mice exhibit severe osteopenia with elevated resorption decreased mineralization. In primary culture, osteoclast...
Mutations in the genes encoding cartilage associated protein (CRTAP) and prolyl 3-hydroxylase 1 (P3H1 encoded by LEPRE1) were first identified causes of recessive Osteogenesis Imperfecta (OI). These proteins, together with cyclophilin B (encoded PPIB), form a complex that 3-hydroxylates single proline residue on α1(I) chain (Pro986) has cis/trans isomerase (PPIase) activity essential for proper collagen folding. Recent data suggest 3-hydroxylation Pro986 is not required structural stability...
ABSTRACT Osteogenesis imperfecta (OI) is a group of genetic disorders characterized by brittle bones that are prone to fracture. Although previous studies in animal models investigated the mechanical properties and material composition OI bone, little work has been conducted statistically correlate these parameters identify key compositional contributors impaired bone behaviors OI. Further, although increased TGF-β signaling demonstrated as contributing mechanism pathology models,...
ABSTRACT Osteogenesis imperfecta (OI), also known as brittle bone disease, displays a spectrum of clinical severity from mild (OI type I) to severe early lethality II), with features including low mass, fractures, and deformities. Mutations in the FK506 Binding Protein 10 ( FKBP10 ), gene encoding 65‐kDa protein FKBP65, cause recessive form OI Bruck syndrome, latter being characterized by joint contractures addition mass. We previously showed that Fkbp10 expression is limited bone, tendon,...
Elevated serum concentrations of glucocorticoids (GCs) result in excessive lipid accumulation white adipose tissue (WAT) as well dysfunction thermogenic brown (BAT), ultimately leading to the development obesity and metabolic disease. Here, we hypothesized that activation sympathetic nervous system either via cold exposure or use a selective β3-adrenergic receptor (β3-AR) agonist alleviates adverse effects chronic GC rodents. To this end, male 10-wk-old C57BL/6NRj mice were treated with...