A5059894322- Mesenchymal stem cell research
- Connective tissue disorders research
- Hematopoietic Stem Cell Transplantation
- Bone fractures and treatments
- Protease and Inhibitor Mechanisms
- Sarcoma Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Spinal Cord Injury Research
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Assistive Technology in Communication and Mobility
- Gaze Tracking and Assistive Technology
- Anesthesia and Neurotoxicity Research
- Islamic Finance and Banking Studies
- Biosensors and Analytical Detection
- Energy and Environmental Systems
- Ubiquitin and proteasome pathways
- Cancer-related cognitive impairment studies
- TGF-β signaling in diseases
- Bacterial Identification and Susceptibility Testing
- Banking stability, regulation, efficiency
- Microfluidic and Capillary Electrophoresis Applications
Baylor College of Medicine
2017-2024
The Ohio State University
2022
Neurological Research Institute
2022
Human periosteal skeletal stem cells (P-SSCs) are critical for cortical bone maintenance and repair. However, their in vivo identity, molecular characteristics, specific markers remain unknown. Here, single-cell sequencing revealed human periosteum contains SSC clusters expressing known markers, PDPN PDGFRA. Notably, P-SSCs, but not marrow SSCs (BM-SSCs), selectively expressed newly identified LRP1 CD13. These LRP1+CD13+ P-SSCs were perivascular with high osteochondrogenic minimal adipogenic...
Periosteum and bone marrow (BM) both contain skeletal stem/progenitor cells (SSCs) that participate in fracture repair. However, the functional difference selective regulatory mechanisms of SSCs different locations are unknown due to lack specific markers. Here, we report a comprehensive gene expression analysis (BM-SSCs), periosteal (P-SSCs), more differentiated osteoprogenitors by using reporter mice expressing Interferon-inducible Mx1 NestinGFP, previously known SSC We first defined...
Osteogenesis imperfecta (OI) is characterized by short stature, skeletal deformities, low bone mass, and motor deficits. A subset of OI patients also present with joint hypermobility; however, the role tendon dysfunction in pathogenesis largely unknown. Using Crtap -/- mouse model severe, recessive OI, we found that mutant Achilles patellar tendons were thinner weaker increased collagen cross-links reduced fibril size at 1- 4-months compared to wildtype. Patellar from mice had altered...
Macau has the uppermost population density and fourth-highest GDP per capita in world. Macau’s banking system is regarded as one of most important indicators macroeconomic growth stability during its transformation into a wealthy modern metropolis. In this study, we use sample 26 banks to explore relationship bank competition, efficiency from return China 1999 2016. Our results demonstrate that competition does cause throughout study period. We also find indications positive but not...
Periosteal skeletal stem cells (P-SSCs) are essential for lifelong bone maintenance and repair, making them an ideal focus the development of therapies to enhance fracture healing. rapidly migrate injury supply new chondrocytes osteoblasts Traditionally, efficacy a cytokine induce cell migration has only been conducted in vitro by performing transwell or scratch assay. With advancements intravital microscopy using multiphoton excitation, it was recently discovered that 1) P-SSCs express...
Abstract Periosteum and bone marrow (BM) both contain skeletal stem/progenitor cells (SSCs) that participate in fracture repair. However, the functional difference selective regulatory mechanisms of SSCs different location are unknown due to lack specific markers. Here, we report a comprehensive gene expression analysis (BM-SSCs), periosteal (P-SSCs), more differentiated osteoprogenitors by using reporter mice expressing Interferon-inducible Mx1 Nestin GFP , previously known SSC We first...
ABSTRACT Osteogenesis imperfecta (OI) is characterized by short stature, skeletal deformities, low bone mass with fragility, and motor deficits. A subset of OI patients also present joint hypermobility; however, the role tendon/ligament dysfunction in pathogenesis largely unknown. Using Crtap -/- mouse model severe, recessive OI, we found that mutant Achilles tendons patellar ligaments were thinner increased collagen cross-links reduced fibril size at 1- 4-months compared to wildtype....
Periosteal skeletal stem cells (P-SSCs) are essential for lifelong bone maintenance and repair, making them an ideal focus the development of therapies to enhance fracture healing. rapidly migrate injury supply new chondrocytes osteoblasts Traditionally, efficacy a cytokine induce cell migration has only been conducted in vitro by performing transwell or scratch assay. With advancements intravital microscopy using multiphoton excitation, it was recently discovered that 1) P-SSCs express...