A5001980598- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Bariatric Surgery and Outcomes
- Muscle metabolism and nutrition
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Vitamin D Research Studies
- Metabolism, Diabetes, and Cancer
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Lipid metabolism and biosynthesis
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Obesity and Health Practices
- Apelin-related biomedical research
- Diabetes and associated disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Folate and B Vitamins Research
- Inflammatory mediators and NSAID effects
The University of Sydney
2015-2023
Anzac Research Institute
2019-2023
Concord Repatriation General Hospital
2019-2023
University of California, Davis
2006-2022
Sax Institute
2022
Westmead Institute for Medical Research
2015-2019
UNSW Sydney
2010-2019
Garvan Institute of Medical Research
2009-2019
Westmead Institute
2015-2019
Westmead Hospital
2017
Positron emission tomography (PET)-computed (CT) has identified metabolically active supraclavicular fat in adult humans based on uptake of labeled glucose and confirmed to be brown adipose tissue (BAT) histologically. However, PET-CT estimated a prevalence BAT as low 5% humans, casting doubt its significance. The true is unknown because the suboptimal sensitivity standard PET-CT.The objective study was determine whether present PET-negative fat.This prospective cohort study.The conducted at...
Abstract Background It has long been recognized that vitamin D deficiency is associated with muscle weakness and falls. Vitamin receptor (VDR) present at very low levels in normal muscle. Whether plays a direct role function unknown subject of hot debate. Myocyte‐specific deletion VDR would provide strategy to answer this question. Methods (mVDR) null mice were generated by crossing human skeletal actin‐Cre floxed mice. The effects gene on the phenotype studied terms body tissue composition,...
The original cohortThe 45 and Up Study ('the Study') was developed to enhance population health.The provides researchers with reliable data on a wide range of exposures outcomes public health importance for the ageing population.The profile paper published in 2008 early stage recruitment, describing recruitment process characteristics first 36 645 (14%) participants. 1The present profiles final cohort 267 357 men women enrolled from general New South Wales (NSW) includes updates.Sampling...
Fructose consumption in the USA has increased over past three decades. During this time, obesity, insulin resistance and metabolic syndrome have also prevalence. While diets high fructose been shown to promote increase TAG concentrations animals, there are insufficient data available regarding long-term effects of humans. The objective present study was investigate 10-week fructose-sweetened beverages human subjects under energy-balanced conditions a controlled research setting. Following...
Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) cholesteryl ester transfer protein (CETP) mass activity; plasma insulin levels measured at 1, 3, 6, GBP surgery....
Brown adipose tissue (BAT) plays key roles in thermogenesis and energy homeostasis rodents. Metabolic imaging using positron emission tomography (PET)-computer has identified significant depots of BAT the supraclavicular fossa adult humans. Whether fat contains precursor brown adipocytes is unknown. The aim present study was to determine adipogenic potential cells human fat. We obtained biopsies from six individuals, as guided by PET-computer tomography, with paired sc negative controls....
OBJECTIVE: Peroxisome proliferator-activated receptor-gamma 2 (PPAR gamma 2) is an important regulator of adipose tissue metabolism and insulin sensitivity. The aim this investigation was to determine whether a PPAR Pro12Ala polymorphism associated with cardiovascular risk factors (obesity, blood pressure, diabetes lipids) in Western Australian Caucasians (n=663). DESIGN: Subjects were selected from two population studies (the Carotid Ultrasound Disease Assessment Study (CUDAS) Busselton...
Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated both increased decreased risk of cardiovascular disease. We examined whether is total mortality in older adults well-characterised body composition. analysed data from 3,075 well-functioning aged 69–79 years at baseline. Mortality were obtained over 6.6 ± 1.6 years. used Cox proportional hazards models adjusting for covariates stages to examine the association between mortality. There 679...
Summary Objective Here we use a novel ELISA that is specific for full‐length visfatin (PBEF/NAMPT), compare it with the existing C‐terminal based assay and to investigate associations of metabolic parameters. Design, patients measurements We established specificity effectiveness new evaluated clinical, anthropometric parameters in cross‐sectional study 129 Thai subjects, consisting 50 outpatients type 2 diabetes 79 healthy volunteers. Results The accurately recovered recombinant detected...
Protein tyrosine phosphatase (PTP)-1B antagonizes insulin signaling and is a potential therapeutic target for resistance associated with obesity type 2 diabetes. To date, studies of PTP-1B have been limited by the availability specific antagonists; however, treatment rodents antisense oligonucleotides (ASOs) directed against improves sensitivity, inhibits lipogenic gene expression, reduces triglyceride accumulation in liver adipose tissue. Here we investigated ASO-mediated inhibition...
Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites human and murine islets in recipient mice, comparing vein with quadriceps muscle kidney, spleen capsules. Murine were isolated from C57BL6/J mice transplanted syngeneic recipients. Human either severe combined immunodeficiency (SCID) or...
The metabolic syndrome (MetS) confers an increased risk for diabetes and cardiovascular disease. Although high-sensitive C-reactive protein (hsCRP) concentrations are higher adiponectin lower in MetS, there is no reliable biochemical measure that can capture its various features. We evaluated whether hsCRP, adiponectin, or the ratio of oligomers, especially high-molecular-weight (HMW) oligomer, to hsCRP predict MetS 123 subjects with compared 91 healthy control subjects. had significantly...