A5100454917- Connective tissue disorders research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Bacterial Genetics and Biotechnology
- RNA Research and Splicing
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Chronic Myeloid Leukemia Treatments
- Metabolism and Genetic Disorders
- Bacteriophages and microbial interactions
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- S100 Proteins and Annexins
- Cancer Research and Treatments
- Osteoarthritis Treatment and Mechanisms
- Medical Research and Treatments
- Plant Gene Expression Analysis
- Bone health and treatments
- Chronic Lymphocytic Leukemia Research
- TGF-β signaling in diseases
Anhui Agricultural University
2023-2025
Baylor College of Medicine
2008-2024
Zhengzhou People's Hospital
2023-2024
Henan Provincial People's Hospital
2019-2024
Zhengzhou University
2002-2024
Yancheng Teachers University
2024
Jiangnan University
2024
Capital Medical University
2017-2024
Beijing Tian Tan Hospital
2023-2024
First Affiliated Hospital of Fujian Medical University
2022-2024
Mesenchymal stem cell-derived osteochondroprogenitors express two master transcription factors, SOX9 and RUNX2, during condensation of the skeletal anlagen. They are essential for chondrogenesis osteogenesis, respectively, their haploinsufficiency causes human dysplasias. We show that directly interacts with RUNX2 represses its activity via evolutionarily conserved high-mobility-group runt domains. Ectopic expression full-length or RUNX2-interacting domain in mouse osteoblasts results an...
Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue characterized by bone fragility and low mass. Recently, our group others reported that WNT1 recessive mutations cause OI, whereas heterozygous early onset osteoporosis. These findings support the hypothesis an important WNT ligand regulating formation homeostasis. While these studies provided strong human genetic in vitro functional data, vivo animal model to study mechanism function lacking. Here, we show Swaying...
ABSTRACT Osteogenesis imperfecta (OI) is characterized by low bone mass, poor quality, and fractures. Standard treatment for OI patients limited to bisphosphonates, which only incompletely correct the phenotype, seem be less effective in adults. Sclerostin-neutralizing antibodies (Scl-Ab) have been shown beneficial animal models of osteoporosis, dominant resulting from mutations genes encoding type I collagen. However, Scl-Ab has not studied recessive OI. Cartilage-associated protein (CRTAP)...
The mammalian gastrointestinal (GI) tract is a complex organ system with twist—a significant portion of its composition community microbial symbionts. microbiota plays an increasingly appreciated role in many clinically-relevant conditions. It important to understand the details biofilm development GI since bacteria this state not only use biofilms improve colonization, often exhibit high levels resistance common, clinically relevant antibacterial drugs. Here we examine initial colonization...
piR-823 is a newly discovered colorectal cancer marker with high diagnostic efficacy. However, the current quantification methods have complicated operations and cost, which restrict its clinical application. Herein, metal-organic framework (MOF) UiO-66 prototype structure supports gold nanoclusters (Au NCs), Au NCs/UiO-66-NH2, were prepared as model nanobiosensing platform for ratiometric detection of exosomal piR-823. The rolling circle amplification process provides sensitivity ensures...
Summary The Yersinia type III secretion system (T3SS) is environmentally responsive to enable its rapid induction upon contact with host cells and necessary for Yersiniae establish a replicative niche cause disease. YopD, translocator protein, represses the expression of T3SS genes until signalled by environmental cues, mechanism known as low calcium response. In this work, we investigated recognition target pestis YopD. Expression all was induced in yopD mutant, though not same degree,...
Abstract Background The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants identified, but these explain little the variation BMI. Recent studies reported associations between DNA methylation obesity, mostly non-Asian populations. Methods We performed an epigenome-wide association study (EWAS) on general adiposity (body mass index, BMI) abdominal (waist circumference, WC) 409 multi-ethnic individuals...
The DNA-processing region of the Enterococcus faecalis pheromone-responsive plasmid pCF10 is highly similar to that otherwise unrelated pRS01 from Lactococcus lactis. A transfer-proficient derivative was unable mobilize plasmids containing origin transfer, oriT. In contrast, oriT-containing could be mobilized by at a low frequency. Relaxases PcfG and LtrB were both capable binding single-stranded oriT DNAs; specific for its cognate oriT, whereas recognize However, pcfG complement an ltrB...
ABSTRACT RECQ DNA helicases play critical roles in maintaining genomic stability, but their role development has been less well studied. Rothmund-Thomson syndrome, RAPADILINO, and Baller-Gerold syndrome are rare genetic disorders caused by mutations the RECQL4 gene. These patients have significant skeletal developmental abnormalities including radial ray, limb craniofacial defects. To investigate of Recql4 developing system, we generated conditional knockout mice targeting lineage....
Many delicious and nutritional macrofungi are widely distributed used in East Asian regions, considered as edible medicinal foods. In this study, 11 species of dried fresh, macrofungi, Ganoderma amboinense, Agaricus subrufescens, Dictyophora indusiata, Pleurotus sajor-caju, ostreatus, geesteranu, Hericium erinaceus, Stropharia rugosoannulata, sapidus, Antrodia camphorata, Lentinus edodes (Berk.) Sing, were investigated to determine the content their components, including proteins, fat,...
Bacterial type IV coupling proteins (T4CPs) bind and mediate the delivery of DNA substrates through associated secretion systems (T4SSs). T4CPs consist a transmembrane domain, conserved nucleotide-binding domain (NBD), sequence-variable helical bundle called all-alpha (AAD). In T4CP structural prototype, plasmid R388-encoded TrwB, NBD assembles as homohexamer resembling RecA ring helicases, AAD, which sits at channel entrance homohexamer, is structurally similar to N-terminal 1 recombinase...
Tools for regulated gene expression in Enterococcus faecalis are extremely limited. In this report, we describe the construction of an vector E. faecalis, designated pCIE, utilizing PQ pheromone-responsive promoter plasmid pCF10. We demonstrate that is tightly repressed, responds to nanogram quantities peptide pheromone, and has a large dynamic range. To its utility, was used control toxic peptides two par family toxin-antitoxin (TA) loci present parpAD1 pAD1 parEF0409 located on chromosome....
Pathogenic variants in genes encoding components of the BRG1-associated factor (BAF) chromatin remodeling complex have been associated with intellectual disability syndromes. We identified heterozygous, novel ACTL6A, a gene component BAF complex, three subjects varying degrees disability. Two missense affecting highly conserved amino acid residues within actin-like domain. Missense mutations homologous region yeast actin were previously reported to be dominant lethal and impaired binding...
The effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion HCC cells. And the HER2/EGFR-MAPK/ERK signal participated process above. More frequent lung metastases were observed an LL-37-overexpressing hematogenous model. Interestingly, 1,25(OH)2D3 together with si-LL-37 significantly 1,25(OH)2D3-induced inhibition PLC/PRF-5 cells, also...