A5081750734- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Lymphatic System and Diseases
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Vascular Malformations and Hemangiomas
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- Skin and Cellular Biology Research
- Systemic Sclerosis and Related Diseases
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Immune responses and vaccinations
- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
- Diagnosis and Treatment of Venous Diseases
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University Hospital Cologne
2019-2024
University of Cologne
2017-2024
RWTH Aachen University
2004-2020
Universitätsklinik für Augenheilkunde
2017
Universitätsklinikum Aachen
2007-2009
Interleukin (IL)-6 is a pleiotropic cytokine involved in the differentiation and proliferation of hematopoietic cells. Hepatocytes respond to IL-6 with synthesis secretion acute-phase proteins. In addition, plays role as migration factor vivo. present paper, we studied potential mediate human primary T cells cell-derived cell lines. was found induce only presence extracellular matrix, suggesting cross-talk between IL-6- integrin signal transduction pathways. Furthermore, an gradient required...
Persistent activation of the transcription factor STAT3 has been detected in many types cancer and plays an important role tumor progression, immune evasion metastasis. To analyze persistent we coexpressed with v-Src. We found that tyrosine phosphorylation by v-Src is independent Janus kinases (Jaks), canonical activators STATs. The STAT3-induced feedback inhibitor, suppressor cytokine signaling 3 (SOCS3), did not interfere However, protein inhibitor activated (PIAS3) suppressed gene...
Abstract Macrophages contribute to the innate immune response by eliminating bacteria, viral particles, and apoptotic bodies. They develop from circulating monocytes. In case of an infection, monocytes attach endothelial cells blood vessels, migrate along cells, leave circulatory system enter inflammatory tissue, differentiate into macrophages. Cell migration is induced frequently chemokines that act through G-protein-coupled receptors. Only a few cytokines signaling single-transmembrane...
Leukocyte recruitment is pivotal for the initiation and perpetuation of inflammatory bowel disease (IBD) controlled by specificity interactions chemokines adhesion molecules. Interactions molecules α4β7-integrin mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) promote accumulation pathogenic T-cell populations in inflamed intestine. We aimed to elucidate significance β7-integrin expression on innate immune cells pathogenesis IBD. demonstrate that deficiency protects...
Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after transplantation. However, there no established treatment to regress pre-existing pathological blood and lymphatic vessels. This study assessed the possibility both vessel types by photodynamic therapy (PDT) intravenous (i.v.) verteporfin injection, influence of timing PDT effect on graft survival in high-risk keratoplasty.BALB/c mice were used suture-induced inflammatory...
Down-regulation of interleukin (IL)-6-type cytokine signaling has been shown to occur, among other mechanisms, via induction the feedback inhibitor SOCS3 (suppressor 3). Binding phosphorylated Tyr759 in cytoplasmic region gp130, common signal transducing receptor chain all IL-6-type cytokines, is necessary for inhibition Janus kinase-mediated signaling. In present study, we analyzed effect on transduction by proinflammatory oncostatin M (OSM), which signals through a complex gp130 and OSM...
Abstract Lymphangiogenesis is a key player in several diseases such as tumor metastasis, obesity, and graft rejection. Endogenous regulation of lymphangiogenesis only partly understood. Here we use the normally avascular cornea model to identify endogenous regulators lymphangiogenesis. Quantitative trait locus analysis large low-lymphangiogenic BALB/cN x high-lymphangiogenic C57BL/6 N intercross prioritization by whole-transcriptome sequencing novel gene responsible for differences lymphatic...
ObjectiveTo investigate the genetic cause, clinical characteristics and potential therapeutic targets of infantile corneal myofibromatosis.DesignCase series with functional in vitro analyses.SubjectsFour individuals from two unrelated families signs myofibromatosis were investigated.MethodsExome-based panel sequencing for PDGFRB NOTCH3 was performed respective index patients. One clinically affected member each family tested pathogenic variant detected by Sanger sequencing....
Fuchs endothelial corneal dystrophy (FECD) is a genetic and age-associated disease characterized by an accelerated loss of cells increased subendothelial deposition extracellular matrix (ECM). Clinically, advanced leads to edema with subsequent reduction in visual acuity. In the majority patients FECD, fibrillar layer (FL) appears on posterior surface. This FL mostly localized inferotemporal quadrant, marks areas significantly reduced cell density thickness sense can be visualized measured...
Background & AimsAberrant lymphocyte homing could potentially link inflammatory processes in the intestine and liver, as distinct hepatobiliary diseases frequently develop extra-intestinal manifestations bowel disease. In this study, we examined role of gut-tropic leukocyte adhesion molecule β7 integrin its endothelial ligand mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) immune-mediated hepatitis mice.MethodsWild-type (WT) mice, MAdCAM-1-deficient integrin-deficient RAG-2–deficient...
Topical application of vascular endothelial growth factor A (VEGFA) inhibitors including Bevacizumab is used for antiangiogenic therapy at the ocular surface. While clinical studies have suggested that this approach well-tolerated, effect drug on limbal epithelial stem cells has not been studied. In study, phenotype and functionality putative (SC) was investigated. The human assessed in terms metabolic activity scratch wound closure. different treatment groups featured no difference...
Abstract Angiogenesis and immune protection are essential at the onset of tumorigenesis. serves to nourish tumor, prevention defenses, for example, by dendritic cells (DCs), allows tumor growth. In this study, we investigated whether there factors with dual functions that both angiogenic immunomodulatory represent a therapeutic target. We analyzed 1) innate responses intratumorally in draining lymph nodes 2) conjunctival melanoma (CM), potentially lethal malignant ocular surface whose...
Purpose: To explore the impact of iris color on outcome Descemet membrane endothelial keratoplasty (DMEK). Methods: Consecutive cases Fuchs dystrophy after DMEK were retrospectively analyzed from prospective Cologne database between 2011 and 2017 at University Cologne, Germany. Iris pictures graded by into blue, green, or brown compared regarding parameters including best-corrected visual acuity (converted to logarithm minimal angle resolution), central corneal thickness, cell density (ECD),...