A5041969251- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood properties and coagulation
- Protease and Inhibitor Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Occupational and environmental lung diseases
- Connective Tissue Growth Factor Research
- Tuberculosis Research and Epidemiology
- Erythrocyte Function and Pathophysiology
- Pharmacogenetics and Drug Metabolism
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- Sphingolipid Metabolism and Signaling
- Signaling Pathways in Disease
- Drug Transport and Resistance Mechanisms
- Chronic Myeloid Leukemia Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Complement system in diseases
- Vitamin K Research Studies
- Caveolin-1 and cellular processes
The University of Texas Health Science Center at Tyler
2014-2023
The University of Texas at Tyler
2023
University of Pennsylvania
2023
The University of Texas Health Science Center at Houston
2020-2023
Oklahoma Medical Research Foundation
2023
Washington University Medical Center
2023
The University of Texas System
2008-2014
Novo Nordisk (Denmark)
2002-2004
Johnson & Johnson (United States)
2002
The University of Texas at Austin
2000
Abstract —A number of studies suggest that moderate consumption red wine may be more effective than other alcoholic beverages in decreasing the risk coronary heart disease mortality. The phytochemical resveratrol found wine, derived from grapes, has been thought to responsible for cardiovascular benefits associated with because it was shown have antioxidant and antiplatelet activities. In present investigation, we examined effect on induction tissue factor (TF) expression vascular cells were...
Although factor VII/factor VIIa (FVII/FVIIa) is known to interact with many non-vascular cells, activated monocytes, and endothelial cells via its binding tissue (TF), the interaction of FVII/FVIIa unperturbed endothelium role this in clearing from circulation are unknown. To investigate this, present study we examined radiolabeled FVIIa subsequent internalization. <sup>125</sup>I-FVIIa bound non-stimulated human umbilical vein (HUVEC) time- dose-dependent manner. The specific independent TF...
Extracellular interactions of plasma clotting factor VIIa (FVIIa) with tissue (TF) on cell surfaces trigger the intracellular signaling events. At present, it is unclear how these signals influence phenotype. To elucidate this, we have used cDNA microarray technology to examine changes in transcriptional program human fibroblasts response exposure FVIIa. microarrays revealed that FVIIa binding TF up-regulated expression <i>Cyr61</i> and <i>CTGF</i> (connective growth factor), genes encode...
Abstract Binding of plasma factor VII(a) to tissue (TF) initiates the coagulation cascade. In health, TF is not expressed in endothelial cells. However, cells express response lipopolysaccharide (LPS), tumor necrosis factor-α (TNFα), and other biological stimuli. expression by implicated thrombotic disorders patients with a variety clinical disorders. present study, we demonstrate that curcumin (diferulolylmethane), known anticarcinogenic anti-inflammatory agent, inhibited phorbol...
Angiogenesis is indispensable during fracture repair, and vascular endothelial growth factor (VEGF) critical in this process. CCN1 (CYR61) an extracellular matrix signaling molecule that has been implicated neovascularization through its interactions with several integrin receptors. shown to be up-regulated the reparative phase of healing; however, role therein remains unclear. Here, regulation expression osteoblasts functional consequences thereof were studied. Stimulation VEGF resulted a...
Tetradecanoyl phorbol acetate (TPA) has been shown to inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced mouse P46OIAl benzo[a]pyrene hydroxylase activity (Raunio, H., and Pelkonen, 0. (1983) Cancer Res.43,782-786).When we co-administered TPA TCDD C67BL/6 mice, the accumulation of TCDD-inducible liver P46OIA1 P46OIA2 mRNA, as well kidney P4SOIA1 was greatly inhibited.When nuclear run-on assays were conducted, maximal levels transcriptional activation achieved for both Cypla-1 Cypla-2...
Tissue factor (TF) is the cellular receptor for an activated form of clotting VII (VIIa) and binding VII(a) to TF initiates coagulation cascade. Sequence structural patterns extracted from a global alignment confers homology with interferon receptors cytokine super family. Several recent studies suggested that could function as genuine signal transducing receptor. However, it unknown which biological function(s) cells are altered upon ligand, VIIa, TF. In present study, we examined effect...
Objective— The plasminogen system has been proposed to participate in vascular remodeling and angiogenesis. Although plasmin-mediated proteolysis could contribute these processes, proteolytic targets for plasmin their downstream effector molecules are yet be fully defined. aim of the present study was elucidate potential mechanisms by which affects various cellular processes. Methods Results— Plasmin upregulated expression Cyr61 , a growth factor–like gene that implicated cell proliferation,...
Employing the rabbit liver progesterone-21-hydroxylase P-450 1 cDNA as a probe (Tukey, R.H., Okino, S., Barnes, H., Griffin, K.J., and Johnson, E.F. (1985) J. Biol. Chem. 260, 13347-13354), we have identified highly homologous (81% within coding region) human cDNA, termed Hp1-1, that encodes 490-amino acid protein. Comparison of predicted translation products between homologues demonstrates two proteins are 73% homologous, while increasing to 82% similarity when allowing for conserved amino...