A5050068723- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Health and Medical Studies
- Social and Demographic Issues in Germany
- Medical Practices and Rehabilitation
- Medical and Health Sciences Research
- Genetic Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Parkinson's Disease and Spinal Disorders
- Autism Spectrum Disorder Research
- RNA regulation and disease
- Dementia and Cognitive Impairment Research
- Ginkgo biloba and Cashew Applications
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Biochemical Analysis and Sensing Techniques
- Restless Legs Syndrome Research
- Neurobiology of Language and Bilingualism
- Ocular Surface and Contact Lens
- Cellular transport and secretion
- Nuclear Receptors and Signaling
- Electroconvulsive Therapy Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Glycogen Storage Diseases and Myoclonus
- Amyotrophic Lateral Sclerosis Research
Bellvitge University Hospital
2024
Universitätsklinikum Tübingen
2023
Munich Cluster for Systems Neurology
2023
Neurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson
2023
Parkinson-Klinik Ortenau
2018-2023
Klinik und Poliklinik für Neurologie
2023
Parkinson's UK
2020
Evangelische Kliniken Gelsenkirchen
2013
Hertie Institute for Clinical Brain Research
2004-2012
German Center for Neurodegenerative Diseases
2011-2012
To evaluate whether there exists distinct characteristics in glucocerebrosidase (GBA)-associated Parkinson disease (PD) with regard to motor and nonmotor symptoms as well imaging assessed by transcranial sonography (TCS).Twenty patients PD heterozygous GBA mutations (N370S, L444P) (GBA-PD) comparison 20 sporadic negative for (sPD) were included. We impairment the Unified Parkinson's Disease Rating Scale-III. Nonmotor evaluated using Montreal Cognitive Assessment, Neuropsychiatric Inventory,...
Anteroposterior diameters of the suprapontine midbrain, pons, and collicular plate were measured in 50 patients with various parkinsonian syndromes (Parkinson disease [PD] [n = 20], progressive supranuclear palsy [PSP] 16], multiple-system atrophy striatonigral type 14]) 12 age-matched healthy control subjects by means axial T2-weighted magnetic resonance images. While no differences midbrain diameter found between PD (mean, 18.5 mm) 18.2 mm), PSP had significantly lower 13.4 than (P<.001),...
Genetic stratification of Parkinson's disease (PD) patients facilitates gene-tailored research studies and clinical trials. The objective this study was to describe the design initial data from Rostock International Disease (ROPAD) study, an epidemiological observational aiming genetically characterize ~10,000 participants.Recruitment criteria included (1) diagnosis PD, (2) relative participant with a reportable LRRK2 variant, or (3) North African Berber Ashkenazi Jew. DNA analysis involved...
<b><i>Background:</i></b> Transcranial ultrasound may be used to detect increased iron levels of the substantia nigra (SN) in patients with Parkinson disease (PD) and control subjects. It is not known whether accumulation PD a primary or secondary phenomenon. However, sequence variations genes involved metabolism have been linked basal ganglia disorders. One these ceruloplasmin (Cp), which vitally transport across cell membrane. <b><i>Methods:</i></b> hundred seventy-six according UK Brain...
Abstract The objective of the study was to estimate if altered levels alpha-synuclein can be detected in tear fluid patients with Parkinson’s disease (PD). Therefore, samples 75 PD patients, control subjects and 31 atypical Parkinsonian were collected analyzed triplicates using an ultra-sensitive single molecule array (SIMOA) system applying a human immunoassay. In PD, total soluble significantly increased compared (p = 0.03; AUC vs. controls 0.60). There no difference comparing stratified...
Abstract We report on a 63‐year‐old man with idiopathic Parkinson's disease who developed kyphosis and severe forward flexion of the thoracolumbar spine. A typical feature was an increase during walking or standing it completely disappeared in supine position, mimicking clinical phenomenon camptocormia (bent spine). In addition to abnormal posture, weakness erector spinal muscles, local pain, reddening, elevated temperature paraspinal muscles were evident. Creatine kinase initially elevated,...
Parkinson’s disease is frequently associated with depressive symptoms. When depression occurs at early stages and before the onset of characteristic motor symptoms disease, differential diagnosis major may be difficult. Differences in psychopathological features have been reported by some authors. This study presents data 49 patients 38 depression. The severity was equivalent both groups. Depressive did not differ between two groups exception affective flattening, delusional ideas suicide...
<h3>Objective:</h3> To elucidate possible mechanisms leading to neurodegeneration in patients with <i>glucocerebrosidase</i> (<i>GBA</i>)–associated Parkinson disease (PD) using combined proton (<sup>1</sup>H) and phosphorus (<sup>31</sup>P) magnetic resonance spectroscopic imaging (MRSI) vivo. <h3>Methods:</h3> <sup>1</sup>H <sup>1</sup>H-decoupled <sup>31</sup>P MRSI was performed 13 PD heterozygous <i>GBA</i> mutations (GBA-PD) 19 age- sex-matched healthy controls investigate metabolite...
<h3>Background</h3> Missense mutations in the eukaryotic translation initiation factor 4-γ 1 (<i>EIF4G1</i>) gene have previously been implicated familial Parkinson9s disease (PD). A large PD family with autosomal-dominant segregation showed a heterozygous missense mutation and additional patients were found to unique sequence variants that not observed controls. Subsequent studies reported contradictory findings. <h3>Methods</h3> We assessed relevance of <i>EIF4G1</i> European cohort 2146...
Background Prevalence and time of occurrence prodromal symptoms Parkinson's disease ( PD ) in relation to the onset classical motor manifestation varies between patients. Possible modifying factors might be different genetic architectures predisposing varying burden manifestations. Objectives To characterize phase patients with heterozygous mutations GBA gene compared without mutation. Methods In a retrospective design, 151 participants [47 carrying mutation ), 52 idiopathic healthy elderly...
A proportion of idiopathic Parkinson's disease patients (PDidiopathic ) with dementia show altered CSF profiles amyloid β (Aβ) and Tau. PD Glucocerebrosidase (GBA) mutations (PDGBA present even more cognitive decline than seen in PDidiopathic .The objective this study was to evaluate whether Aβ tau are associated the prominent impairment PDGBA .CSF levels Aβ1-42 , t-Tau, p-Tau, total alpha-synuclein were assessed 479 participants (50 308 121 healthy controls).Older age . Despite impairment,...
There is need for multidimensional quantitative assessment of cognitive driven activities daily living (ADL) functions in Parkinson's disease (PD).To determine whether there an ADL profile related to impairment PD assessed by the Multiple Object Test (MOT). We assumed MOT performance be lower patients versus controls and with more severe impairment.50 no (PD-NC), 54 PD-mild (PD-MCI), 29 dementia (PDD), 40 healthy (HC) were investigated. Besides comprehensive testing, MOT, a based test...