A5059146575- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Fetal and Pediatric Neurological Disorders
- Innovative Approaches in Technology and Social Development
- Autism Spectrum Disorder Research
- Face Recognition and Perception
- Cardiac, Anesthesia and Surgical Outcomes
- Patient Satisfaction in Healthcare
- Enhanced Recovery After Surgery
- Tryptophan and brain disorders
- Plant-based Medicinal Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Psychosomatic Disorders and Their Treatments
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
McMaster University
2017-2024
St. Joseph’s Healthcare Hamilton
2018-2020
Western University
2011
University of Regensburg
2001-2005
University of Würzburg
2003
Psychopathy, a developmental disorder characterized by profound social disturbance, is associated with impaired recognition of distress cues. Since processing and moral socialization are closely linked, uncovering techniques to improve could have positive treatment implications for disorders that feature empathy impairments. Previous studies demonstrate fear-recognition deficits can be remedied redirecting attention critical cues (the eyes fearful faces). However, it remains unclear whether...
Objectives– Administration of botulinum neurotoxin A (BONT/A) is a common and effective treatment blepharospasm. There is, however, no information regarding the emotional social well-being patients with blepharospasm patient acceptance BONT/A therapy. The purpose this study was to investigate aspects quality life level satisfaction treatment. Material methods– Fifty-one who had been treated for years completed questionnaire providing about life. Results– Results revealed reductions in but,...
Major depressive disorder (MDD) is considered a highly heterogeneous clinical and neurobiological mental disorder. We employed novel layered treatment design to investigate whether cortical thickness features at baseline differentiated responders from non-responders after 8 16 weeks of standardized sequential antidepressant treatment. Secondary analyses examined differences between MDD controls as replication analysis longitudinal changes in escitalopram 181 95 healthy comparison (HC)...
Neural network-level changes underlying symptom remission in major depressive disorder (MDD) are often studied from a single perspective. Multimodal approaches to assess neuropsychiatric disorders evolving, as they offer richer information about brain networks. A FATCAT-awFC pipeline was developed integrate computationally intense data fusion method with toolbox, produce faster and more intuitive for combining functional connectivity structural (denoted anatomically weighted (awFC))....
Abstract Task‐based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation neural correlates tasks and their potential changes with over time, understanding the reliability blood‐oxygen‐level dependent (BOLD) signal such is essential. We assessed test–retest an emotional conflict task healthy participants collected as part Canadian Biomarker Integration Network Depression. Data...
Abstract There is a growing interest in examining the wealth of data generated by fusing functional and structural imaging information sources. These approaches may have clinical utility identifying disruptions brain networks that underlie major depressive disorder (MDD). We combined an existing software toolbox with mathematically dense statistical method to produce novel processing pipeline for fast easy implementation fusion analysis ( FATCAT‐awFC ). The was then utilized identify...
COVID-19 has had an extreme effect on older people. Now more than ever we need collaborative approaches to address complex issues within research aging. However, the pandemic dramatically changed way conduct, interact, and organize interdisciplinary groups. This paper describes a case study of how institute for aging managed process change during restrictions. A design lead, researcher centered approach was used understand needs researchers as they adapted across 6 months. Firstly, online...
We present a case of 60-year-old male referred to tertiary psychiatric facility for diagnostic assessment due low mood and behavioural changes. Neurological examination the patient was unremarkable. MRI indicated overt ventriculomegaly with gross dilatation lateral third ventricles. Manual segmentation grey matter, white CSF demonstrated that had ventricular volume almost 46 times greater than healthy volunteers in same age range. Despite his striking degree cortical thinning, he presented...
The hippocampus is implicated in the pathophysiology of major depressive disorder (MDD), with evidence that morphological changes occur disease progression. It was hypothesized treatment-naive patients depression would show performance deficits hippocampus-dependent memory trials, concurrent hippocampal activation on functional magnetic resonance imaging, compared control participants. Thirteen MDD and 13 participants completed a imaging process-dissociation task. On behavioural measures...