A5042920591- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Facial Nerve Paralysis Treatment and Research
- Parkinson's Disease Mechanisms and Treatments
- Animal Virus Infections Studies
- Trigeminal Neuralgia and Treatments
- Viral gastroenteritis research and epidemiology
- Parkinson's Disease and Spinal Disorders
- Myasthenia Gravis and Thymoma
- Ophthalmology and Eye Disorders
- Peripheral Neuropathies and Disorders
- Vestibular and auditory disorders
- Cerebral Venous Sinus Thrombosis
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Autoimmune Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Escherichia coli research studies
- Long-Term Effects of COVID-19
- 3D IC and TSV technologies
- Migraine and Headache Studies
- Neurological diseases and metabolism
- Neuropeptides and Animal Physiology
- Viral Infections and Vectors
University of Pecs
2016-2025
Asklepios Klinik Barmbek
2016-2025
EV Group (Austria)
2023-2024
Technical University of Munich
2024
Asklepios Klinik St. Georg
2021
Szent János Kórház
2021
Klinik und Poliklinik für Neurologie
1997-2020
Asklepios
2020
University of Applied Sciences Landshut
2019
Evangelisches Krankenhaus Königin Elisabeth Herzberge
2009-2011
Background and Purpose— There is currently no consensus on (1) the percentage of patients who develop spasticity after ischemic stroke, (2) relation between initial clinical findings acute (3) impact activities daily living health-related quality life. Methods— In a prospective cohort study, 301 consecutive with signs central paresis due to first-ever stroke were examined in stage 6 months later. At both times, degree pattern muscle tone, Barthel Index, EQ-5D score, standardized instrument...
The aim of this study was to describe the neurological syndrome in largest cohort adult patients with a complicated Shiga toxin-producing Escherichia coli infection. recent outbreak E. serotype O104:H4 northern Germany affected more than 3842 patients, 22% whom developed haemolytic uraemic syndrome. proportion unusually high, and complications were frequent severe. In three hospitals, population-based evaluation 217 infection carried out, including neurological, neuroradiological,...
This study examined the structural diversity and bioactivity of peptaibol compounds produced by species from phylogenetically separated Longibrachiatum Clade filamentous fungal genus Trichoderma, which contains several biotechnologically, agriculturally clinically important species. HPLC-ESI-MS investigations crude extracts 17 (T. aethiopicum, T. andinense, capillare, citrinoviride, effusum, flagellatum, ghanense, konilangbra, longibrachiatum, novae-zelandiae, pinnatum, parareesei,...
The global impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is significant in terms public health effects and its long-term socio-economic implications. Among all social groups, elderly by far most affected age group regarding morbidity mortality. In multiple countries spanning several continents, there are an increasing number reports referencing novel disease-2019 (COVID-19) spread among nursing homes. These areas now recognized as potent hotspots...
Dysferlinopathies are autosomal recessive disorders caused by mutations in the dysferlin (DYSF) gene encoding protein. DYSF lead to a wide range of muscular phenotypes, with most prominent being Miyoshi myopathy (MM) and limb girdle dystrophy type 2B (LGMD2B).We assessed one-year-natural course dysferlinopathy, safety efficacy deflazacort treatment double-blind, placebo-controlled cross-over trial. After one year natural without intervention, 25 patients genetically defined dysferlinopathy...
Abstract Functional metagenomics is a powerful experimental tool to identify antibiotic resistance genes (ARGs) in the environment, but range of suitable host bacterial species limited. This limitation affects both scope identified ARGs and interpretation their clinical relevance. Here we present functional pipeline called Reprogrammed Bacteriophage Particle Assisted Multi-species Metagenomics (DEEPMINE). approach combines improves use T7 bacteriophage with exchanged tail fibres targeted...
We describe two patients who developed subacute axonal peripheral neuropathy under duodopa treatment. Comprehensive diagnostic workup including muscle and sural nerve biopsy revealed that the most probable cause of was cobalamin vitamin B6 deficiency in both patients.
<h3>Objective:</h3> To characterize effects of alemtuzumab treatment on measures disability improvement in patients with relapsing-remitting multiple sclerosis (RRMS) inadequate response (≥1 relapse) to prior therapy. <h3>Methods:</h3> Comparison Alemtuzumab and Rebif Efficacy Multiple Sclerosis (CARE-MS) II, a 2-year randomized, rater-blinded, active-controlled, head-to-head, phase 3 trial, compared efficacy safety 12 mg subcutaneous interferon-β-1a (SC IFN-β-1a) 44 μg RRMS. Prespecified...
Body lateropulsion may occur without signs of vestibular dysfunction and nucleus involvement. The authors examined 10 such patients with three-dimensional brainstem mapping. limb ataxia reflected an impairment vestibulospinal postural control caused by a lesion the descending lateral tract, whereas body was probably consequence impaired or absent proprioceptive information ascending dorsal spino-cerebellar tract.
The effects of resveratrol (RES) in heart failure have already been evaluated animal models; however, human clinical trials, they not confirmed yet. aim this study was to assess the treatment systolic patients (heart with reduced ejection fraction or HFrEF). In trial, 60 outpatients NYHA (New York Heart Association) class II-III HFrEF were enrolled and randomized into two groups: receiving either 100-mg daily placebo for three months. At beginning at end echocardiography, a six-minute walk...
Abstract Background Recent data suggest that gene expression profiles of peripheral white blood cells can reflect changes in the brain. We aimed to analyze transcriptome mononuclear (PBMC) and plasma metabolite levels migraineurs a self-controlled manner during between attacks. Methods Twenty-four patients with migraine were recruited samples collected headache-free (interictal) period headache (ictal) investigate disease- headache-specific alterations. Control from 13 age- sex-matched...
The carpal tunnel ligament often encloses transthyretin-derived (ATTR) amyloid deposits. In this study we tested the hypothesis that ATTR in is most commonly of wildtype origin a Caucasian population without endemic background familial polyneuropathy. All resection specimens from were retrieved Amyloid Registry University Kiel spanning period 2004–2011 and dichotomized into two groups: first group 25 patients was obtained diverse referring pathologists. second comprised patient cohort 73...
Certain Trichoderma species are causing serious losses in mushroom production worldwide. aggressivum and pleuroti among the major causal agents of green mould diseases affecting Agaricus bisporus Pleurotus ostreatus, respectively. The genus is well-known for bioactive secondary metabolites, including peptaibols, which short, linear peptides containing unusual amino acid residues being synthesised via non-ribosomal peptide synthetases (NRPSs). aim this study was to get more insight into...
Migraine is a primary headache with genetic susceptibility, but the pathophysiological mechanisms are poorly understood, and it remains an unmet medical need. Earlier we demonstrated significant differences in transcriptome of migraineurs' PBMCs (peripheral blood mononuclear cells), suggesting role neuroinflammation mitochondrial dysfunctions. Post-transcriptional gene expression regulated by miRNA (microRNA), group short non-coding RNAs that emerging biomarkers, drug targets, or drugs....
Caliciviruses including noro- and sapoviruses of family Caliciviridae are important enteric human swine pathogens, while others, like valoviruses, less known. In this study, we developed a detection typing pipeline for the most prevalent caliciviruses—sapovirus GIII (Sw-SaV), norovirus GII (Sw-NoV), valovirus GI (Sw-VaV). The integrates triplex RT-qPCR, 3′RACE semi-nested PCR, next-generation sequencing (NovaSeq, Illumina) techniques. A small-scale epidemiological investigation was conducted...
CD20+ T-cells were described firstly in peripheral blood and later bone marrow patients with hematological tumors, certain immune-mediated diseases. During our diagnostic work, this peculiar subgroup of lymphocytes has been consistently observed associated untreated monoclonal gammopathy undetermined significance (MGUS) myeloma (MM). Despite the expanding literature data, exact function T cells remains unclear. We investigated incidence MGUS (n=27), MM using a larger cohort (n=125) compared...
Abstract Traditional advanced therapies in Parkinson’s disease (PD) with motor fluctuations and dyskinesias like continuous apomorphine infusion (CSAI), levodopa-carbidopa intestinal gel (LCIG), entacapone (LECIG), or deep brain stimulation (DBS) have played a central role managing therapy-related complications. Recently, subcutaneous foslevodopa/foscarbidopa (CSFLI) has emerged as novel therapeutic option. This manuscript provides insights from one year of real-world experience CSFLI,...
The black-headed gull is the most common nesting species in Hungary. Based on lifestyle and feeding habits of gull, which highly adapted to human environment, they can be carriers spreaders potential other animal pathogens. Between 2014 2018 within framework “Life Bird Ringing program” a total 7 faecal samples were collected from gulls one sample (MR04) was randomly selected for viral metagenomics mass sequencing. 95.4% 4% reads classified into family Seadornaviridae Astroviridae ,...
Mushroom-forming fungi (Agaricomycetes) are emerging as pivotal players in several fields of science and industry. Genomic data for Agaricomycetes accumulating rapidly; however, this is not paralleled by improvements gene annotations, which leave function notoriously poorly understood. We set out to improve our functional understanding the model mushroom Coprinopsis cinerea integrating a new, chromosome-level assembly, high-quality predictions, information derived from broad gene-expression...