A5065400172- Pancreatitis Pathology and Treatment
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Pancreatic function and diabetes
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Inflammatory Bowel Disease
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Health and Medical Studies
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Vitamin K Research Studies
- Child Nutrition and Feeding Issues
- Biomedical and Chemical Research
- Intestinal Malrotation and Obstruction Disorders
- Diet, Metabolism, and Disease
- Diverticular Disease and Complications
- Diabetes Management and Research
Israelitisches Krankenhaus
2013-2024
Universität Hamburg
2005-2022
Ospedale Israelitico
2014
Bielefeld University
2014
Praxis
2010
Emory University
2000
Leipzig University
2000
University Hospital Magdeburg
2000
Takeda (Germany)
2000
Medical College of Wisconsin
2000
To study the effects of intraileal nutrients on human pancreatic secretion and gastrointestinal motility, nine healthy subjects were intubated with an oroileal multilumen tube for ileal perfusion, duodenal juice aspiration, intestinal motility recording. The duodenum was perfused continuously essential amino acids to induce submaximal stimulation enzyme fed pattern. Additional perfusion carbohydrate at quantities similar those observed under physiological late postprandial conditions or fat...
Objective Exocrine pancreatic insufficiency (EPI) is frequent in patients with chronic pancreatitis (CP). This 1-year, prospective, multicenter, observational, disease management study aimed to assess symptom improvement and quality of life CP EPI who were receiving enzyme replacement. Methods Patients either assigned cohort 1 that consisted already taking pancreatin (Kreon; Abbott Arzneimittel GmbH, Hannover, Germany) or 2 newly diagnosed without prior treatment. Symptoms documented, was...
We describe two patients who developed subacute axonal peripheral neuropathy under duodopa treatment. Comprehensive diagnostic workup including muscle and sural nerve biopsy revealed that the most probable cause of was cobalamin vitamin B6 deficiency in both patients.
Summary Aim : To assess whether the eradication of Helicobacter pylori leads to long‐term relief symptoms in functional dyspepsia. Methods Eight hundred patients with dyspepsia were randomized receive double‐blind treatment twice‐daily 30 mg lansoprazole, 1000 amoxicillin and 500 clarithromycin for 7 days (L AC), 15 or once‐daily lansoprazole 14 (LP). Dyspepsia reflux monitored 12 months. Results In intention‐to‐treat analysis, non‐ulcer sum score showed a statistically significant benefit...
It is assumed that in humans pancreatic and gastrointestinal motor responses to a meal are coordinated regulated mainly by duodenal nutrient exposure. On the other hand, there evidence distal intestine may participate regulation of functions. The aim this study was compare human intestinal motility correlate them with exposure proximal intestine. After intubation an oroileal multilumen tube for marker perfusion, ileal aspiration, manometry, 14 healthy subjects received mixed test (1,257 kJ)....
It is unclear why patients with inflammation of the distal bowel complain symptoms referable to upper gastrointestinal tract, specifically gastric emptying (GE) disturbances. Thus we aimed determine occurrence and putative pathomechanisms motor disorders in such patients. Thirteen healthy subjects (CON), 13 Crohn's disease (CD), 10 ulcerative colitis (UC), 7 diverticulitis (DIV) underwent a standardized (13)C-octanoic acid breath test. Plasma glucose, CCK, peptide YY, glucagon-like peptide-1...
We determined if changes in the irregular motor activity of phase II, dominant motility awake fasting humans, are associated with fluctuations pancreatic secretion by intubating upper gastrointestinal tract 15 healthy humans and recording antral duodenal obtaining samples for one or two interdigestive cycles. Antral II was graded as having low, intermediate, high frequency contractions related to trypsin output plasma concentrations motilin human polypeptide (HPP), a marker vagal cholinergic...
The noninvasive ¹³C-mixed triglyceride breath test (¹³C-MTG-T) has been shown to diagnose severe pancreatic exocrine insufficiency reliably. We hypothesized that sensitivity of the could be increased by strict limitation physical activity, correction for gastric emptying velocity, and/or lipid dose.In 10 healthy volunteers and 9 patients with suspected disease, a secretin test, modified ¹³C-MTG-T (250 mg ¹³C-MTG, 26 g fat, samples over 8 hours), ¹³C-octanoic acid were performed. Subjects...
Amylase inhibition has gastrointestinal and metabolic effects that may aid in the treatment of diabetes obesity. We tested whether 4 g a commercially available wheat amylase inhibitor (WAI) affected postprandial carbohydrate (CHO) absorption plasma glucose or hormones. Twelve persons (four lean four obese nondiabetics type II diabetics) were studied on 2 separate days. After eating weight maintenance diet (55% CHO, 20% protein, 25% fat, as percentage calories) for 3 days, subjects ate...
Human interdigestive intestinal motility follows a circadian rhythm with reduced nocturnal activity, but pancreatic exocrine secretion is unknown. To determine whether changes in occur and are associated motor events, enzyme outputs, proximal jejunal motility, plasma polypeptide concentrations were measured during consecutive daytime nighttime periods (12 h each) seven healthy volunteers using orojejunal multilumen intubation. Studies randomly started the morning or evening. Nocturnally,...