A5008968732- Hepatocellular Carcinoma Treatment and Prognosis
- vaccines and immunoinformatics approaches
- Glioma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Aquatic Ecosystems and Phytoplankton Dynamics
- MicroRNA in disease regulation
- Marine Invertebrate Physiology and Ecology
- Lymphoma Diagnosis and Treatment
- Biocrusts and Microbial Ecology
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Evolution and Genetic Dynamics
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Cytokine Signaling Pathways and Interactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Hydrolysis and Bioactive Peptides
- Blood properties and coagulation
- Assisted Reproductive Technology and Twin Pregnancy
- Hypothalamic control of reproductive hormones
- Genomics and Phylogenetic Studies
- Circadian rhythm and melatonin
- Advanced Proteomics Techniques and Applications
- Proteins in Food Systems
University of Pecs
2019-2024
Medical University of Białystok
2019-2022
Abstract Functional metagenomics is a powerful experimental tool to identify antibiotic resistance genes (ARGs) in the environment, but range of suitable host bacterial species limited. This limitation affects both scope identified ARGs and interpretation their clinical relevance. Here we present functional pipeline called Reprogrammed Bacteriophage Particle Assisted Multi-species Metagenomics (DEEPMINE). approach combines improves use T7 bacteriophage with exchanged tail fibres targeted...
Primary central nervous system lymphomas (PCNSL) are aggressive non-Hodgkin affecting the (CNS). Although immunophenotyping studies suggested an uniform activated B-cell (ABC) origin, more recently a spectrum of ABC and germinal center (GC) cases has been proposed, with molecular subtypes PCNSL still being matter debate. With emergence novel therapies demonstrating different efficacy between GC patient groups, precise assignment subtype is becoming indispensable. To determine 77 17 secondary...
Evidence has been accumulating that elements of the vertebrate pituitary adenylate cyclase-activating polypeptide (PACAP) system are missing in non-chordate genomes, which is at odds with partial sequence-, immunohistochemical-, and physiological data literature. Multilevel experiments were performed on great pond snail (Lymnaea stagnalis) to explore role PACAP invertebrates. Screening neuronal transcriptome genome did not reveal homologs system. Despite this, immunohistochemical...
The Rotimer (rotifer-specific biopolymer) like SCO-spondin (R-SSPO/1), predicted as the main component of this biopolymer, is an adequate base for design functional small peptides. This macromolecule interactive and protective against neurotoxic human-type beta-amyloid 1-42 aggregates (agg-Aβ). current work presents biological investigations predictable molecular interaction analysis DSSNDL PNCRDGSDE peptides that were synthesized based on sequences R-SSPO/1. Viability assays (NADH-dependent...
Non-small cell lung cancer (NSCLC) encompasses distinct histopathological subtypes, namely adenocarcinoma (AC) and squamous carcinoma (SCC), which require precise differentiation for effective treatment strategies. In this study, we present a novel molecular diagnostic model that integrates tissue-specific expression profiles of microRNAs (miRNAs) obtained through next-generation sequencing (NGS) to discriminate between AC SCC subtypes NSCLC. This approach offers more comprehensive...
Non-small cell lung cancer is the predominant form of and associated with a poor prognosis. MiRNAs implicated in initiation progression can be easily detected liquid biopsy samples have potential to serve as non-invasive biomarkers. In this study, we employed next-generation sequencing globally profile miRNAs serum from 71 early-stage NSCLC patients 47 non-cancerous pulmonary condition patients. Preliminary analysis differentially expressed revealed 28 upregulated compared control group....
The in vivo investigation of kynurenic acid (KYNA) and its analogs is one the recent exciting topics pharmacology. In current study we assessed biological effects these molecules on bdelloid rotifers (Philodina acuticornis Adineta vaga) by monitoring changes their survival phenotypical characteristics. addition to longitudinal (slowly changing) markers (survival, number alive body size index), some dynamic (quickly responding) ones (cellular reduction capacity mastax contraction frequency)...
Although non-invasive pre-implantation genetic testing for aneuploidy (NIPGT-A) is potentially appropriate to assess chromosomal ploidy of the embryo, practical application it in a routine IVF centre have not been started absence recommendation. Our objective this study was provide comprehensive workflow clinically applicable strategy NIPGT-A based on next-generation sequencing (NGS) technology with corresponding bioinformatic pipeline. In retrospective study, we performed NGS spent...
The rotifer-specific biopolymer, namely Rotimer, is a recently discovered group of the biomolecule family. Rotimer has an active role in biofilm formation initiated by rotifers (e.g., Euchlanis dilatata or Adineta vaga) female-male sexual interaction monogononts. To understand Ca2+- and polarity-dependent this multifunctional viscoelastic material, it essential to explore its molecular composition. investigation rotifer-enhanced Rotimer-inductor conglomerate (RIC) yielded several protein...
Albinism is characterized by a variable degree of hypopigmentation affecting the skin and hair, causing ophthalmologic abnormalities. Its oculocutaneous, ocular syndromic forms follow an autosomal or X-linked recessive mode inheritance, 22 disease-causing genes are implicated in their development. Our aim was to clarify genetic background Hungarian albinism cohort. Using 22-gene panel, 11 17 patients elucidated. In with unidentified backgrounds (n = 6), whole exome sequencing performed....
OMICS methods brought significant advancements to the understanding of tumor cell biology, which transformed treatment and prognosis several cancers. Clinical practice outcomes, however, changed significantly less in case glioblastoma (GBM). In this study, we aimed assess utility whole exome (WES) sequencing clinical setting. Ten pairs formalin-fixed, paraffin-embedded (FFPE) GBM specimens were obtained at onset (GBM-P) recurrence (GBM-R). Histopathological molecular features all samples...
Competitive athletes are often exposed to extreme physiological loading, resulting in over excessive mechanotransduction during their acute intensive training sessions and competitions. Individual differences genetics affect how they cope with these challenges, as reflected high performances. Olympic Medalists prohibited from providing atypical values the Hematological Module of Athlete Biological Passport. Since there was no aphysiological result maintained his innocence, a whole genome...
The Rotimer, a rotifer-specific biopolymer, is an exogenic bioactive exudate secreted by different monogonant species (e.g. Euchlanis dilatata or Lecane bulla). production of this viscoelastic biomolecule induced micro-particles, thereby forming special Rotimer-Inductor Conglomerate (RIC) in web format. In case, the water insoluble Carmine crystals, filtered to size (max. diameter was 50 µm), functioned as inductor. RIC adequate empirical indicator follow up filamentous biopolymer secretion...
Investigation of human neurodegeneration-related aggregates beta-amyloid 1–42 (Aβ42) on bdelloid rotifers is a novel interdisciplinary approach in life sciences. We reapplied an organ size-based vivo monitoring system, exploring the autocatabolism-related alterations evoked by Aβ42, glucose-supplemented starvation model. The experientially easy-to-follow size reduction bilateral reproductive (germovitellaria) fasted was rescued serving as nutrient source- and peptide sequence-specific...
The rotifer-specific exogenic biopolymer, named Rotimer and its related molecular processes are affected by physical chemical factors (e.g., temperature, pH or metal ions); however, the study of biological influences presence protozoa) concerning particle-dependent reproduction (egg laying) 'biopolymer producing capacity' (BPC) rotifers is objective present work. Non-planktonic rotifer species (Philodina acuticornis, Adineta vaga, Euchlanis dilatata, Lecane bulla) were studied in paired...
Abstract There is a long-standing debate about the presence and functionality of pituitary adenylate cyclase-activating polypeptide (PACAP) in non-bilaterians, protostomes, invertebrate deuterostomes. Evidence has been accumulating that homologous sequences to genes encoding PACAP peptides their receptors vertebrates are missing genomes. This at odds, however, with partial sequence-, immunohistochemical-, physiological evidence literature. In this study, we first sequenced neural...