A5043893972- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Cholesterol and Lipid Metabolism
- Trace Elements in Health
- Amino Acid Enzymes and Metabolism
- Cancer Genomics and Diagnostics
- Prion Diseases and Protein Misfolding
- Genetic Neurodegenerative Diseases
- Optical Polarization and Ellipsometry
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Pituitary Gland Disorders and Treatments
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Cell Image Analysis Techniques
- Medical Imaging Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cholinesterase and Neurodegenerative Diseases
Oslo University Hospital
2016-2025
University of Oslo
2016-2025
University of Lübeck
2015-2024
University of Latvia
2018-2024
Tel Aviv University
2022-2024
University Medical Center
2024
University Hospital and Clinics
2024
Latvia University of Life Sciences and Technologies
2022
Leibniz Institute of Plant Biochemistry
2014-2021
Austrian Institute of Technology
2019
Deposition of the beta-amyloid peptide (Abeta) in brain occurs during normal ageing and is substantially accelerated patients with Alzheimer's disease. Since Abeta continuously produced brain, it has been suggested that a clearance mechanism should exist to prevent its accumulation subsequent aggregation. Until now, little attention paid possible role P-glycoprotein (P-gp), member ATP binding cassette superfamily transporter proteins, pathogenesis A recent study demonstrated Abeta40 Abeta42...
Flowers sensu lato are short, specialized axes bearing closely aggregated sporophylls. They typical for seed plants (spermatophytes) and prominent in flowering stricto (angiosperms), where they often comprise an attractive perianth. There is evidence that spermatophytes evolved from gymnosperm-like with a fern-like mode of reproduction called progymnosperms. It seems plausible, therefore, the stamens/carpels pollen sacs/nucelli homologous to fern sporophylls sporangia, respectively. However,...
In Alzheimer disease (AD), the intracerebral accumulation of amyloid-β (Aβ) peptides is a critical yet poorly understood process. Aβ clearance via blood-brain barrier reduced by approximately 30% in AD patients, but underlying mechanisms remain elusive. ABC transporters have been implicated regulation levels brain. Using mouse model which animals were further genetically modified to lack specific transporters, here we shown that transporter ABCC1 has an important role cerebral and...
Abstract Neuronal subthreshold excitability and firing behaviour are markedly influenced by the activation deactivation of somato‐dendritic hyperpolarization‐activated cation current ( I h ). Here, we evaluated possible contributions to hyperexcitability in an animal model absence seizures (WAG/Rij rats). We investigated pyramidal neurons somatosensory neocortex, site generation spike–wave discharges. ‐mediated functions from WAG/Rij rats, Wistar rats (sharing same genetic background with...
Abstract Background Brain tumor surgery must balance the benefit of maximal resection against risk inflicting severe damage. The impact increased is diagnosis-specific. However, precise diagnosis typically uncertain at due to limitations imaging and intraoperative histomorphological methods. Novel accurate strategies for brain classification are necessary support personalized neurosurgical treatment decisions. Here, we describe a fast cost-efficient workflow tumors based on DNA methylation...
Tacrine (THA), a long withdrawn drug, is still popular scaffold used in medicinal chemistry, mainly for its good reactivity and multi-targeted effect. However, THA-associated hepatotoxicity an issue must be considered drug discovery based on the THA scaffold. Following our previously identified hit compound 7-phenoxytacrine (7-PhO-THA), we systematically explored chemical space with 30 novel derivatives, focus low hepatotoxicity, anticholinesterase action, antagonism at GluN1/GluN2B subtype...
It has been shown in vitro that β-amyloid (Aβ) is transported by P-glycoprotein (P-gp). Previously, we demonstrated Aβ immunoreactivity significantly elevated brain tissue of individuals with low expression P-gp vascular endothelial cells. These findings led us to hypothesize might be involved the clearance normal aging and particularly Alzheimers disease (AD). As were interested early pathogenesis deposition, studied correlation between cerebral amyloid angiopathy (CAA) samples from 243...
We developed PCR primers against highly conserved regions of the rRNA operon located within inverted repeat chloroplast genome and used these to amplify region spanning from 3' terminus 23S gene 5' 5S gene. The sequence this roughly 500-bp region, which includes 4.5S two intergenic transcribed spacer (cpITS2 cpITS3), was determined 20 angiosperms, 7 gymnosperms, 16 ferns (21,700 bp). Sequences for large subunit ribulose bisphosphate carboxylase/oxygenase (rbcL) same or confamilial genera...
Metastases are responsible for cancer deaths, but the molecular alterations leading to tumor progression unclear. Overexpression of E2F1 transcription factor is common in high-grade tumors that associated with poor patient survival. To investigate association enhanced activity aggressive phenotype, we performed a gene-specific silencing approach metastatic melanoma model. Knockdown endogenous via small hairpin RNA (shRNA) expression increased E-cadherin SK-Mel-147 cells and reduced their...
The proteome of a proliferating human stem cell line was analyzed and then utilized to detect differentiation-associated changes in the protein profile. analysis conducted with stable fetal midbrain (ReNcell VM) that displays properties neural cell. Therefore, acquisition proteomic data should be representative cultured cells (hNSCs) general. Here we present 2-DE protein-map this annotations 402 spots representing 318 unique proteins identified by MS. subsequent profiling differentiating at...
Alzheimer's disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in brain, thus leading to neurodegeneration and cognitive impairment. Plaque formation depends not merely on amount generated Aβ peptides, but more importantly their effective removal. Chronic infections neurotropic pathogens, most prominently parasite Toxoplasma (T.) gondii, are frequent elderly, it has been suggested that resulting neuroinflammation may influence course AD. In present study, we...
Soluble β-amyloid peptides (Aβ) and small Aβ oligomers represent the most toxic peptide moieties recognized in brains affected by Alzheimer's disease (AD). Here we provide first evidence that specific St. John's wort (SJW) extracts both attenuate Aβ-induced histopathology alleviate memory impairments APP-transgenic mice. Importantly, these effects are attained independently of hyperforin. Specifically, two characterized low hyperforin content (i) significantly decrease intracerebral Aβ42...
Huntington's Disease (HD) is caused by inheritance of a single disease-length allele harboring an expanded CAG repeat, which continues to expand in somatic tissues with age. The inherited disease expresses toxic protein, and whether further expansion adds toxicity unknown. We have created HD mouse model that resolves the effects expansions. show here suppressing substantially delays onset littermates inherit same allele. Furthermore, pharmacological inhibitor, XJB-5-131, inhibits lengthening...
Abstract Context Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% 2% develop metastases being classified as carcinomas (PCs). For unknown reasons, the corticotroph overrepresented among APTs PCs. Mutations in alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling telomere maintenance, have been implicated development several cancer types, including neuroendocrine...
During storage in the silk gland, N-terminal domain (NT) of spider proteins (spidroins) keeps aggregation-prone repetitive region solution at extreme concentrations. We observe that NTs from different spidroins have co-evolved with their respective repeat region, and now use an NT is distantly related to previously used NTs, for efficient recombinant production amyloid-β peptide (Aβ) implicated Alzheimer's disease. A designed variant Nephila clavipes flagelliform spidroin, which nature...
We applied the wide-field Mueller imaging polarimetry for screening of formalin-fixed paraffin-embedded samples mouse brain tissue at different stages β-amyloidosis in Alzheimer's disease (AD). The accumulation amyloid-beta (Aβ) deposits throughout is one key pathological hallmarks observed with AD progression. demonstrate that presence Aβ plaques influences properties backscattered polarized light, particular, its degree depolarization. By means statistical analysis, we high-order moments...