A5038154659- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Hormonal and reproductive studies
- Adrenal and Paraganglionic Tumors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diet and metabolism studies
- Diabetes and associated disorders
- Glioma Diagnosis and Treatment
- Diabetes Management and Research
- Childhood Cancer Survivors' Quality of Life
- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- Cardiovascular Issues in Pregnancy
- Emergency and Acute Care Studies
- Hypothalamic control of reproductive hormones
- Thyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Gestational Diabetes Research and Management
- Sexual function and dysfunction studies
- Myasthenia Gravis and Thymoma
Linköping University
2016-2025
Linköping University Hospital
2002-2024
Norrköping Hospital
2022-2024
Karolinska Institutet
2023
County Administrative Board
2019
University of Bergen
2017
Sorbonne Université
2009
Uppsala University Hospital
2007
Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet more physiological exposure-time cortisol profile. The aim compare pharmacokinetics metabolic between OD the same daily dose of thrice-daily (TID) conventional tablets. We conducted an open, randomized, two-period, 12-wk crossover multicenter trial 24-wk extension at five university hospital...
Patients with hypopituitarism have an increased standardized mortality rate. The basis for this has not been fully clarified.To investigate in detail the cause of death a large cohort patients subjected to long-term follow-up.All-cause and cause-specific 1286 Swedish prospectively monitored KIMS (Pfizer International Metabolic Database) 1995-2009 were compared general population data National Cause Death Registry. In addition, events reported KIMS, medical records, postmortem reports...
Whether patients with Cushing disease (CD) in remission have increased mortality is still debatable. To study overall and disease-specific predictive factors an unselected nationwide cohort of CD. A retrospective diagnosed CD, identified the Swedish National Patient Registry between 1987 2013. Medical records were systematically reviewed to verify diagnosis. Standardized ratios (SMRs) 95% CIs calculated Cox regression models used identify predictors mortality. Of 502 CD (n = 387 women; 77%),...
To describe clinical and pathological characteristics treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).Electronic survey August 2020-May 2021.96% 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven considered clinically benign, demonstrated behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% men. Adrenocorticotrophic hormone (ACTH)-secreting constituted 30% APT/PC,...
Context: Obesity is a frequent manifestation of hypothalamic damage from craniopharyngioma (CP). It not yet clarified whether the obesity due to alterations in energy expenditure, i.e. basal metabolic rate (BMR) and physical activity, or increased intake (EI).
Hypothalamic damage caused by craniopharyngioma (CP) is associated with poor functional outcome.To assess cognitive function and quality of life in childhood-onset CP on hormonal replacement, including GH treatment.A cross-sectional study a median follow-up time 20 years (1-40).Patients were recruited from the South Medical Region Sweden.The included 42 patients (20 women) surgically treated for between 1958 2000. Patients aged ≥17 years. Equally many controls, matched age, sex, residence,...
Studies on the incidence of Cushing's disease (CD) are few and usually limited by a small number patients. The aim this study was to assess annual in nationwide cohort patients with presumed CD Sweden. Patients registered diagnostic code for syndrome (CS) or CD, between 1987 2013 were identified Swedish National Patient Registry. diagnosis validated reviewing clinical, biochemical, imaging, histopathological data. Of 1317 identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six...
Abstract Context Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% 2% develop metastases being classified as carcinomas (PCs). For unknown reasons, the corticotroph overrepresented among APTs PCs. Mutations in alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling telomere maintenance, have been implicated development several cancer types, including neuroendocrine...
Mortality from primary and secondary adrenal insufficiency (AI; PAI SAI, respectively) is 2-3-fold higher than in the general population. relates to cardiovascular disease, acute crisis (AC), cancer infections; however, there has been little further characterization of patients who have died.We analysed real-world data 2034 (801 PAI, 1233 SAI) European Adrenal Insufficiency Registry (EU-AIR; NCT01661387). Baseline clinical biochemical subsequently died were compared with those remained...
Abstract Context Whether multisystem morbidity in Cushing’s disease (CD) remains elevated during long-term remission is still undetermined. Objective To investigate comorbidities patients with CD. Design, Setting, and Patients A retrospective, nationwide study of CD identified the Swedish National Patient Register between 1987 2013. Individual medical records were reviewed to verify diagnosis status. Main Outcomes Standardized incidence ratios (SIRs) 95% confidence intervals (CIs) calculated...
Context Craniopharyngioma patients without GH therapy are at an increased cardiovascular disease (CVD) risk and particularly concerning women. No previous study on long-term in adults with childhood onset (CO) craniopharyngioma was identified. Objective To investigate CVD CO complete hormone replacement, including therapy, to the impact of disease-related factors risk. Design participants In a cross-sectional operated craniopharyngiomas (1958–2000) from defined area Sweden (2.5 million), we...
Context and objective Treatment for adrenal insufficiency (AI) remains suboptimal. Despite glucocorticoid replacement, patients with AI have reduced life expectancy quality of life. This study aimed to describe the spectrum management replacement in enrolled European Adrenal Insufficiency Registry (EU-AIR). Design, setting EU-AIR is a prospective, multinational, multicentre, observational initiated August 2012 monitor long-term safety routine clinical practice Germany, Netherlands, Sweden UK...
Prednisolone is used as glucocorticoid replacement therapy for adrenal insufficiency (AI). Recent data indicate that its use in AI associated with low bone mineral density. Data on risk factors cardiovascular disease patients treated prednisolone are scarce, despite this condition being the predominant cause of excess mortality. We aimed to address question using real-world from European Adrenal Insufficiency Registry (EU-AIR).EU-AIR, comprising 19 centres across Germany, Netherlands, Sweden...
The role of cabergoline in Cushing's disease (CD) remains controversial. experience is limited to case reports and few open studies that report the effects determined after ≥1 month treatment. In prolactinomas dopamine-responsive GH-secreting tumours, are seen within days or weeks. Here, we searched for short-term CD.Twenty patients (19 naïve one recurrent) were included a prospective study. Cabergoline was administered increasing doses 0.5-5 mg/week over 6 weeks.Urinary free cortisol (UFC)...
OBJECTIVE To study relationships between leptin and factors regulating body composition as well metabolic risk factors. Furthermore, to the effects of GH on leptin. DESIGN Cross‐sectional population‐based. Regarding GH, prospective interventional. PATIENTS One hundred eleven women 107 men, 20–70 years old, randomly selected from population registry in community Linköping, Sweden. Ten GH‐deficient subjects were given until normalization IGF‐I levels. MEASUREMENTS Venous blood was drawn...
Changes observed during adult GH deficiency (GHD) are most often reversed with the administration of recombinant human (rhGH). To avoid daily injections, a long-acting molecule has been obtained by covalent binding polyethylene glycol (PEG) rhGH (PEG-GH), allowing weekly s.c. injections. This study was designed to assess its efficacy and safety, in GHD subjects.This randomized, double-blind, placebo-controlled, multiple-dose, parallel group study. Subjects were recruited from 34 centers. A...
Abstract Fracture risk in GHD patients is not definitely established. Studying fracture incidence 832 on GH therapy and 2581 matched population controls, we recorded a doubled CO women, but significantly lower AO men. Introduction: The objective of this study was to evaluate with confirmed growth hormone deficiency (GHD) replacement (including [GH]) compared while also taking potential confounders effect modifiers into account. Materials Methods: Eight hundred thirty-two controls answered...
Summary Context Current guidelines on how to divide the daily cortisol substitution dose in patients with primary adrenal insufficiency ( PAI ) are controversial and mainly based empirical data. Objective To assess an equal of hydrocortisone HC given either four times or twice influence diurnal profiles ACTH , patient preferences health‐related quality life HRQ o L ). Design Double blind, crossover. Methods Fifteen (six women) were included. Capsules placebo at 07:00, 12:00, 16:00 22:00 h...
Objective The objective was to assess the long-term safety profile of dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency (AI). Design Randomised, open-label, crossover trial DR-HC or thrice-daily for 3 months each (stage 1) followed by two consecutive, prospective, open-label studies 6 2) and 18 3) at five university clinics Sweden. Methods Sixty-four adults primary AI started stage 1, an additional 16 entered 3. Patients received 20–40 mg once daily divided into...
To describe the treatment and long-term outcomes of patients with acromegaly from all healthcare regions in Sweden.Analysis prospectively reported data Swedish Pituitary Register 698 (51% females) diagnosed 1991 to 2011. The latest clinical follow-up date was December 2012, while mortality were collected for 28.5 years until June 2019.The annual incidence 3.7/million; 71% had a macroadenoma, 18% visual field defects, 25% at least one pituitary hormone deficiency. Eighty-two percent surgery,...
To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI).Prospective, open-label, multicenter, 5-year extension study DR-HC conducted at five university clinics Sweden.Seventy-one adult diagnosed AI who were receiving stable recruited. Safety outcomes included adverse events (AEs), intercurrent illness episodes, laboratory parameters vital...
Psychiatric symptoms are common in Cushing's disease (CD) and seem only partly reversible following treatment.To investigate drug dispenses associated to psychiatric morbidity CD patients before treatment during long-term follow-up.Nationwide longitudinal register-based study.University Hospitals Sweden.CD diagnosed between 1990 2018 (N = 372) were identified the Swedish Pituitary Register. Longitudinal data was collected from 5 years before, at diagnosis, follow-up. Four matched controls...
Women with Turner syndrome (TS) have an increased risk of aortic dissection. The current recommended cutoff to prevent dissection in TS is size index (ASI) ≥2.5 cm/m2. This study estimated which had the best predictive value for dissection, and whether adjusting body improved prediction.A prospective, observational Sweden, women TS, n = 400, all evaluated echocardiography aorta data on medical history up 25 years. Receiver operating characteristic (ROC) curves, sensitivity specificity were...