A5027092637- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- LGBTQ Health, Identity, and Policy
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Thyroid Disorders and Treatments
- Stress Responses and Cortisol
- Reproductive Health and Technologies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Meningioma and schwannoma management
- Thyroid Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Diet and metabolism studies
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Biochemical Analysis and Sensing Techniques
- Bone health and treatments
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
Tel Aviv Sourasky Medical Center
2016-2025
Tel Aviv University
2016-2025
Institute of Endocrinology
1998-2024
Academic College of Tel Aviv-Yafo
2023
Génétique Médicale & Génomique Fonctionelle
2023
Centre de Génétique Médicale de Marseille
2023
Evangelismos Hospital
2019-2023
Polyclinic General Hospital
2019
University of Padua
2018
Cedars-Sinai Medical Center
1994-2015
To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects temozolomide (TMZ) treatment.Electronic survey to ESE members Dec 2015-Nov 2016.Reports on 166 (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% the clinically functioning, most frequent immunohistochemical subtype corticotroph (45%). Ki-67 index did not distinguish APT from median 7% 10%...
Abstract Purpose The 14th Acromegaly Consensus Conference was convened to consider biochemical criteria for acromegaly diagnosis and evaluation of therapeutic efficacy. Methods Fifty-six experts from 16 countries reviewed discussed current evidence focused on assays; the role imaging, pathology, clinical assessments; consequences diagnostic delay; remission recommendations follow up; value assessment monitoring in defining disease progression, selecting appropriate treatments, maximizing...
Ghrelin is a potent GH secretagogue that also plays an important role in appetite and weight regulation. increases hunger food intake, its levels decrease after standard meal or glucose.To examine the effects of oral glucose, lipid protein loads on ghrelin levels, investigating possibility these responses may be modulated by several anthropometric metabolic factors.There were 24 adult nondiabetic subjects (13 men/11 women; mean age 55.3 +/- 2.9 years, range 26-74 years). Each participant...
Hyperprolactinaemia in humans may be associated with a high prevalence of obesity but the nature this link is poorly defined. The aim study was to establish relationship between hyperprolactinaemia and body weight patients prolactin-secreting pituitary tumours.We conducted retrospective prolactinoma treated at Endocrine Institute Tel Aviv Medical Center, Israel, during period 1989-1996. Patients clinically non-functioning macroadenomas (NFA) served as control group. Data on demographic...
Postoperative management of clinically nonfunctioning pituitary adenomas (NFPA) presents difficult challenges. There are no good serum markers for presence or growth the tumour, medical treatment is not effective and radiotherapy carries risk significant side-effects.The purpose this study was to investigate natural history biological behaviour surgically treated NFPA, with a special effort identify characteristics indicative more aggressive course that could assist in clinical...
The expression of three somatostatin receptor subtypes, SSTR3, SSTR4, and SSTR5, was evaluated in 33 pituitary tumor specimens. SSTR3 studied by reverse transcription coupled to polymerase chain reaction, whereas SSTR4 SSTR5 determined ribonuclease protection assay. expressed 6 7 GH-secreting tumors, all 8 clinically nonfunctioning 3 prolactinomas, 1 2 ACTH-secreting tumors tested. Eight adenomas had undetectable messenger ribonucleic acid levels only them SSTR5. also 11 In contrast, highly...
Stressful experiences modulate neuro-circuitry function, and the temporal trajectory of these alterations, elapsing from early disturbances to late recovery, heavily influences resilience vulnerability stress. Such effects stress may depend on processes that are engaged during resting-state, through active recollection past anticipation future events, all known involve default mode network (DMN). By inducing social acquiring resting-state functional magnetic resonance imaging (fMRI) before...
A novel oral octreotide formulation was tested for efficacy and safety in a phase III, multicenter, open-label, dose-titration, baseline-controlled study patients with acromegaly.We enrolled 155 complete or partially controlled (IGF-1 <1.3 × upper limit of normal [ULN], 2-h integrated GH <2.5 ng/mL) receiving injectable somatostatin receptor ligand (SRL) ≥ 3 months. Subjects were switched to 40 mg/d capsules (OOCs), the dose escalated 60 then up 80 control IGF-1. Subsequent fixed doses...
Clinically nonfunctioning pituitary adenoma (NFPA) remains the only tumor subtype for which no effective medical therapy is available or recommended. We evaluated dopamine agonist (DA) preventing growth of postsurgical remnants.The study design included historical cohort analysis clinical results at two referral centers with different standard practices postoperative NFPA management: DA conservative follow-up.Seventy-nine patients followed 8.8±6.5 years were treated DA, initiated upon...
To describe clinical and pathological characteristics treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).Electronic survey August 2020-May 2021.96% 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven considered clinically benign, demonstrated behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% men. Adrenocorticotrophic hormone (ACTH)-secreting constituted 30% APT/PC,...
The expression of two somatostatin receptor subtypes, SSTR1 and SSTR2, was studied in 27 pituitary tumors 1 chronic lymphocytic leukemia infiltrate. Solution hybridization techniques were used for RNA analysis. SSTR2 were, respectively, expressed 3 7 9 10 GH-secreting tumors, 5 nonfunctioning 4 0 prolactinomas, ACTH-secreting tumors. infiltrate the subtype. No correlation detected among tumor size, level hormonal hypersecretion, status. Two acromegalic patients who responded to octreotide...
OBJECTIVE We have shown previously that in contrast to the standard high‐dose 250‐μg ACTH test, a low‐dose 1‐μg stimulation test correctly identified all patients with pituitary disease who had impaired hypothalamo–pituitary–adrenal (HPA) function. In this study we further compared performances of these two tests as screening procedures for possible HPA impairment. DESIGN A comparison and healthy controls whose axis status was characterized formally by gold test. SUBJECTS total 89 subjects...
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Abstract The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. Pituitary Society coordinated the Neoplasm Nomenclature (PANOMEN) workshop address topic. Experts in developmental biology, pathology, neurosurgery, endocrinology, and oncology, including representatives nominated Society, European Endocrinology, Neuroendocrine Association,...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (&lt;65...
Summary Objective There is no consensus as to the optimal postoperative treatment of patients with clinically nonfunctioning pituitary adenomas (NFPA) in whom total tumour removal has not been achieved. In this study we assessed whether dopamine agonist (DA) can prevent remnant enlargement NFPA. Design and methods Thirty‐three (25 men/8 women; mean age, 61·7 ± 11·2 years; follow‐up, 40·6 4·8 months) were treated DA, their outcome was compared that 47 untreated (33 men/14 59 2 42·9 4·2...
To assess arterial stiffness in a cohort of hypogonadal males and to investigate the effect testosterone replacement therapy on properties this specific group.Eighteen male patients with untreated acquired hypogonadism due either adult-onset idiopathic hypogonadotropic (n=9) or pituitary tumor 12 age-, sex, weight-matched eugonadal healthy controls were recruited for study. Arterial properties, plasma glucose, lipid profile, total, bioavailable (BT) levels measured fasting state. In...
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus are central components systems regulating appetite and energy homeostasis. Here we report on establishment a mouse model which ribonuclease III Dicer-1 has been specifically deleted from POMC-expressing (POMC(ΔDCR)), leading to postnatal cell death. Mice born phenotypically normal, at expected genetic ratio with normal hypothalamic POMC-mRNA levels. At 6 weeks age, no POMC neurons/cells could be detected either or...