The role of the low dose (1 microgram) ACTH stimulation test in evaluation patients with pituitary diseases was systematically assessed by relating its results to those obtained on gold standard tests hypothalamo-pituitary-adrenal (HPA) reserve, such as insulin-induced hypoglycemia or a metyrapone challenge. Ten (8 men and 2 women) proven impairment HPA function 9 (5 4 similar pathologies but preserved were studied (pituitary controls). A group 7 normal volunteers (3 served controls. None...

OBJECTIVE We have shown previously that in contrast to the standard high‐dose 250‐μg ACTH test, a low‐dose 1‐μg stimulation test correctly identified all patients with pituitary disease who had impaired hypothalamo–pituitary–adrenal (HPA) function. In this study we further compared performances of these two tests as screening procedures for possible HPA impairment. DESIGN A comparison and healthy controls whose axis status was characterized formally by gold test. SUBJECTS total 89 subjects...

Abstract —The cardiovascular effect of estrogen is currently under intense investigation, but the role androgens in vascular biology has attracted little attention. Because endothelial repair and smooth muscle cell (VSMC) proliferation affect atherogenesis, we analyzed effects 17β-estradiol (E 2 ), dihydrotestosterone (DHT), sex hormone antagonists on DNA synthesis human umbilical VSMCs E304 cells (a line). In VSMCs, both E DHT had a biphasic [ 3 H]thymidine incorporation into DNA: low...

Hypertension is often cited as a risk factor for erectile dysfunction. To clarify the relation between hypertension and dysfunction, we evaluated 32 consecutive hypertensive 78 normotensive impotent men with respect to multiple potential determinants parameters of function, including medical sexual history, depression, hormonal profile, penile nocturnal tumescence, vascular supply, pudendal nerve conduction. The were older, had higher body mass index, used more medications than men. groups...

Diabetes mellitus is an emerging epidemic in the Arab world. Although high diabetes prevalence documented Israeli Arabs, information from cohort studies scant.This a population study, based on derived between 2007-2011, electronic database of largest health fund Israel, among Arabs and Jews. Prevalence, 4-year-incidence hazard ratios [HRs], adjusted for sex metabolic-syndrome [MetS]-components, were determined 3 age groups (<50 years, 50-59 ≥60 years).The study included 17,044 (males: 49%,...

New-onset diabetes mellitus (DM) in elderly patients is associated with increased risk of complications and mortality. It unknown whether glycemic control this population influences the mortality risk.The current study was conducted using computerized database Sharon-Shomron District Clalit Health Services Israel. Included were subjects 65 years age above new-onset DM. The primary outcome measures all-cause coronary revascularization procedures either percutaneous intervention or artery...

Objective Diabetes prevalence among ethnic minorities and immigrants often differs from the majority indigenous population. We compared diabetes prevalence, incidence risk Ethiopian non-Ethiopian Jews. Within these main groups, we controlled for effect of migration on by comparing subgroups former Soviet Union (FSU) immigrants, both with Israeli-born Methods The study cohort included adult (n = 8,398) age-matched Jews 15,977) subgroups: 7,994), FSU 1,541) 10,828). annual incidence, hazard...

To compare gestational diabetes mellitus (GDM) risk among two ethnic minority groups, with high type-2 (T2DM) prevalence, as compared to the Jewish population majority group.A historical cohort study was conducted using clinical data collected between January 1, 2007, and December 31, 2011. The sample included 20-45-year-old women; 2938 Ethiopian, 5849 Arab 5156 non-Ethiopian women. GDM defined according two-step strategy: step 1: glucose ≥ 140 mg/dl 2: Coustan Carpenter's diagnostic...

We have previously shown that the vasopressor effect of angiotensin II (Ang II) is inhibited by lipoxygenase (LO) blockers. To elucidate specific mechanism involved, we studied relationship between contractile Ang and LO products in a human placental preparation. In perfused cotyledons, (boluses 1 to 10 microg) increased perfusion pressure 12-hydroxyeicosatetraenoic acid (12-HETE) release. The blockers phenidone n-propyl gallate reduced maximal II-induced increment from 26+/-3 16+/-3 18+/-4...

The renal threshold for glucose (RT(G)) is determined by the nephron's reabsorptive capacity. Glucose reabsorbed through sodium-coupled cotransporters in proximal tubules. During pregnancy, capacity decreases, possibly, due to reduced transporter expression. Our hypothesis that inadequate decrease RT(G) during pregnancy will make women more prone develop gestational diabetes mellitus (GDM).Pregnant (n = 40) who were referred our center oral tolerance test (OGTT) included analysis. Plasma...

The lipoxygenase pathway has been implicated in the growth, migration, and contraction of vascular smooth muscle cells (VSMCs). However, precise type present wall not characterized. In this study, we used a specific reverse-transcriptase polymerase chain reaction method with 2 sets primers on total RNA polyA (+)RNA normal human VSMCs prepared from umbilical artery. Two forms platelet-type 12-lipoxygenase mRNA were VSMCs: already published form cloned erythroleukemia variant 12-lipoxygenase,...

Background: Although osteoporosis is a major public concern, little research attention has been paid to evaluating the manner in which osteoporotic patients perceive their illness. The aim of current study was examine patients’ cognitive and emotional illness representations see, specifically, if any differences could be correlated with gender. Methods: A convenience sample 102 women 100 men (mean age 66 years both groups) who were diagnosed osteoporosis, attending bone mineral clinics at...

Abstract Objective The 2017 revised Bethesda System for Reporting Thyroid Cytopathology (BSRTC) included new malignancy rates each category as well management recommendations. Here, we evaluate the rate and test performance BSRTC categories in a middle‐sized institution outside United States (US). Design Retrospective single centre case series with chart review. Patients All patients who underwent thyroid surgery preoperative between years 2010 2018 at our institution. Measurements In order...

The state of leukocyte adhesiveness/aggregation (LAA) in the peripheral blood has been employed as a marker inflammation. In present study we examined patients with varying intensities inflammation caused by respiratory tract infections to further investigate reliability LAA for detection and assessment severity disease activity. includes 140 controls, 46 upper infection, 30 bronchitis, 27 suspicion pulmonary infiltrate, 39 small 18 large infiltrate. Assessment was based on assuming an...

The demand for endocrinology services is growing worldwide, particularly among minority and underserved populations, mainly due to the rapid global increase of diabetes. medical education endocrinologists a resource consuming process hospital-based. Yet, given chronic nature endocrine morbidity, greatest in community. However, an isolated endocrinologist cannot cope with changes field. Limited funding hospital facilities does not allow establishment freestanding endocrine-center; thus,...

In this study we examined the possibility that chronic reduction in serum dihydrotestosterone (DHT) attained by pharmacologic inhibition of 5 alpha-reductase modulates sex-hormone-binding globulin (SHBG) levels elderly men. Twenty-one men, ages 58-79 years (mean 66) with benign prostatic hypertrophy were treated inhibitor finasteride (5 mg daily) for 12 months. Serum DHT declined 80% (p < 0.001) and total testosterone rose 14% 0.05). SHBG concentration remained unchanged (44.1 +/- 4.5 vs...

Flat oral glucose tolerance test (OGTT) curve is characterized by low levels, seemingly nonresponsive to load. Few studies have explored flat OGTT during pregnancy and yielded conflicting results, some suggesting risk for fetal growth restriction. This study evaluated the characteristics perinatal outcomes of women with a pregnancy. We found that occurs in younger, leaner pregnant women. Also, was significantly associated male fetus higher levels pregnancy-associated plasma protein A at...

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)