A5053080840- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Muscle metabolism and nutrition
- Thermoregulation and physiological responses
- Adrenal Hormones and Disorders
- Sports Performance and Training
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Childhood Cancer Survivors' Quality of Life
- Adrenal and Paraganglionic Tumors
- Obesity, Physical Activity, Diet
- Exercise and Physiological Responses
- Glioma Diagnosis and Treatment
- Child Nutrition and Feeding Issues
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Cardiovascular and exercise physiology
- Clinical Nutrition and Gastroenterology
- Digestive system and related health
- Metabolism, Diabetes, and Cancer
- Genetic Syndromes and Imprinting
- Gastrointestinal motility and disorders
- Child and Adolescent Health
St James's University Hospital
2015-2025
Leeds Teaching Hospitals NHS Trust
2016-2025
University of Leeds
2015-2025
The Ohio State University
2014-2024
Centre for Addiction and Mental Health
2023
Janssen (United Kingdom)
2023
Nationwide Children's Hospital
1997-2022
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
2022
Newcastle upon Tyne Hospital
2022
Birmingham Children's Hospital
2021
Recess is at the heart of a vigorous debate over role schools in promoting optimal child development and well-being. Reallocating time to accentuate academic concerns growing trend has put recess risk. Conversely, pressure increase activity school come from efforts combat childhood obesity. The purpose this review was examine value as an integral component day.A comprehensive recess-specific literature conducted, beginning with Google Scholar search, cull definitions, position statements,...
Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores first-in-human use antigen-specific immunotherapy with a combination two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in hyperthyroidism.
The purpose of this study was to assess the quality information a lay person could obtain from Internet (Net) sources regarding treatment childhood diarrhea. It also afforded an opportunity evaluate awareness and compliance general medical community with American Academy Pediatrics (AAP) guidelines on management acute diarrhea.This prospective, open, observational, literature review performed computer workstation library. AAP practice parameter gastroenteritis in young children selected as...
Somatostatin (SRIF) analogs provide safe and effective therapy for acromegaly. In a proportion of patients, however, SRIF may lead to discordant growth hormone (GH) IGF-I suppression, which suggests more complex mechanism than attributable inhibition GH release alone. To elucidate whether acts peripherally on the GH–IGF-I axis, we showed that rat hepatocytes express somatostatin receptor subtypes-2 -3 mRNA protein levels were suppressed in dose-dependent manner by administration octreotide....
1. The pharmacological properties of the novel diarylacetamide kappa-opioid receptor agonist, EMD 61753, have been compared with those ICI 197067 (a centrally-acting kappa agonist) and 204448 peripherally-selective agonist). 2. 61753 binds high affinity (IC50 5.6 nM) selectivity (kappa:mu:delta:sigma binding ratio 1:536:125: > 1,786) to receptors is a full potent 54.5 agonist in an vitro assay for (rabbit vas deferens preparation). 3. Systemically-applied [14C]-EMD found concentrations...
This observational study was designed to determine whether football players with a history of heat cramps have elevated fluid and sodium losses during training. During “two-a-day” training camp, five Division I collegiate (20.2 ± 1.6 y, 113 20 kg) (C) were matched (weight, age, race position) cohort teammates (19.6 0.6 110 who had never cramped (NC). Change in body weight (adjusted by intake) determined gross sweat loss. Sweat samples (forearm patch) analyzed for potassium concentrations....
MURRAY, R., G. L. PAUL, J. SEIFERT, D. E. EDDY, and A. HALABY. The effects of glucose, fructose, sucrose ingestion during exercise. Med. Sci. Sports Exerc., Vol. 21, No. 3, pp. 275–282, 1989. purpose this study was to compare the physiological, sensory, exercise performance responses 6% solutions cycling Twelve subjects completed three sessions consisting 115 min intermittent cycle ergometer at 65–80% V̇O2max followed by a timed bout requiring completion 600 pedal revolutions. During each...
Abstract A point‐prevalence study at a tertiary Australian hospital found 199 of 462 inpatients (43%) to be receiving antibiotic therapy. Forty‐seven per cent use was discordant with guidelines or microbiological results and hence considered inappropriate. Risk factors for inappropriate prescribing included bone/joint infections, the absence infection, creatinine level >120 µmol/L, carbapenem macrolide being under care aged care/rehabilitation team. In setting finite antimicrobial...
Hyponatraemia is a very common medical condition that associated with multiple poor clinical outcomes and often managed suboptimally because of inadequate assessment investigation. Previously published guidelines for its management are complex impractical to follow in hospital environment, where patients may present divergent specialists, as well generalists.A group senior, experienced UK clinicians, met develop practical algorithm the hyponatraemia setting. The latest evidence was discussed...
There are limited data concerning the evolution of radiation-induced hypopituitarism in adult-onset brain tumour (AO-BT) survivors, part consequence survival many these individuals. We aim to characterize pituitary-related outcomes following cranial radiotherapy (cXRT) for primary nonpituitary tumours.We retrospectively analysed longitudinal patients with AO-BT who received cXRT within a tertiary cancer referral centre.A total 107 adults (age 40·0 ± 13·1 years) followed median duration 8...
Mortality from primary and secondary adrenal insufficiency (AI; PAI SAI, respectively) is 2-3-fold higher than in the general population. relates to cardiovascular disease, acute crisis (AC), cancer infections; however, there has been little further characterization of patients who have died.We analysed real-world data 2034 (801 PAI, 1233 SAI) European Adrenal Insufficiency Registry (EU-AIR; NCT01661387). Baseline clinical biochemical subsequently died were compared with those remained...
Radiotherapy is a valuable treatment in the management algorithm of pituitary adenomas and craniopharyngiomas. However, risk second brain tumour following radiotherapy major concern. We assessed this using non-irradiated patients with same primary pathology imaging surveillance as controls.In multicentre, retrospective cohort study, 4292 adenoma or craniopharyngioma were identified from departmental registries at six adult endocrine centres (Birmingham, Oxford, Leeds, Leicester, Bristol, UK...
The purpose of this study was to determine how the ingestion carbohydrate at varying rates influences physiological, sensory, and performance responses prolonged exercise 65–75% VO2max. Ten subjects ingested either a water placebo (WP) or solutions formulated provide glucose 26, 52, 78 g. h-1 during 2 h cycling in cool (10°C) environment. Beverages were administered double-blind, counterbalanced design. A 4.8 km test followed each session. average time required complete less with feedings...
Studies of the effect GH on quality life (QOL) in growth hormone deficient (GHD) adults have reported conflicting results. Recently, however, we demonstrated that by selecting only those patients with impaired QOL efficacy replacement can be greatly improved. The improvement was observed to correlate significantly recorded before commencing therapy. This study aims assess if demographic variables affect untreated GHD or following therapy.An open replacement, initiating treatment a dose 0.8...
MURRAY, R., D. E. EDDY, T. W. J. G. SEIFERT, L. PAUL, and A. HALABY. The effect of fluid carbohydrate feedings during intermittent cycling exercise. Med. Sci. Sports Exerc., Vol. 19, No. 6, pp. 597–604, 1987. purpose this study was to determine the ingesting water or solutions on physiologic function performance 1.6 h exercise in heat (dry bulb temperature = 33°C). Thirteen male subjects (24 35 yr) completed four separate rides. Each ride consisted steady-state (at 55 65% VO2max)...
Two subclasses of adenosine receptors, A1 and A2, have been described. The purpose these experiments was to determine compare the renal effects several receptor agonists: (Ado), 2-chloroadenosine (2CA, nonselective), N6-cyclohexyladenosine (CHA, selective), N6-ethylcarboxamide (NECA, A2 selective). Rat kidneys were perfused at constant pressure (105 +/- 5 mmHg) using a Krebs-Henseleit buffer containing 3.5 g/100 ml Ficoll 1.0 bovine serum albumin. Three clearance periods obtained in each...