Alzira Alves de Siqueira Carvalho
A5010895535- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Myasthenia Gravis and Thymoma
- Glycogen Storage Diseases and Myoclonus
- Amyotrophic Lateral Sclerosis Research
- Hereditary Neurological Disorders
- Tracheal and airway disorders
- Neurological diseases and metabolism
- Congenital Heart Disease Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin Diseases and Diabetes
- Neurological and metabolic disorders
- Muscle and Compartmental Disorders
- Parkinson's Disease and Spinal Disorders
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Genetic Syndromes and Imprinting
- Dysphagia Assessment and Management
- Occupational Health and Burnout
- Long-Term Effects of COVID-19
- Nuclear Structure and Function
Faculdade de Medicina do ABC
2015-2025
Faculdade de Tecnologia e Ciências
2024
Hospital Universitário Lauro Wanderley
2023
Universidade Federal da Paraíba
2023
Associação de Medicina Intensiva Brasileira
2023
Universidade do Porto
2023
Fundação de Apoio à Pesquisa do Estado da Paraíba
2023
Hospital São Vicente
2023
University of Liège
2023
Sorbonne Université
2018-2022
<h3>Objective</h3> To evaluate whether eculizumab helps patients with anti–acetylcholine receptor–positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status minimal manifestations (MM), we assessed patients9 throughout REGAIN (Safety and Efficacy Eculizumab in AChR+ Refractory Generalized Gravis) its open-label extension. <h3>Methods</h3> Patients who completed randomized controlled trial continued into...
To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using Quality Life Neurological Disorders (Neuro-QOL) Fatigue subscale, and to correlations between improvements Neuro-QOL other clinical endpoints.Neuro-QOL Fatigue, MG Activities Daily Living (MG-ADL), Quantitative (QMG), 15-item (MG-QOL15) scales were administered during phase 3, randomized, placebo-controlled REGAIN study...
Differential diagnosis of rare idiopathic inflammatory myopathies (IIM) is mainly based on clinical aspects, muscle biopsy analysis, and auxiliary assays that determine myositis-specific associated autoantibodies (MSA MAA). While MSAs are considered specific for their respective IIM subclass, MAAs can be present in more than one subclass other conditions. This study compares results a multispecific line blot assay with the final patients features to draw conclusions test's applicability...
Abstract Objective ANO5 ‐related myopathy is an important cause of limb‐girdle muscular dystrophy (LGMD) and hyperCKemia. The main descriptions have emerged from European cohorts, the burden disease worldwide unclear. We provide a detailed characterization large Brazilian cohort patients. Methods A national cross‐sectional study was conducted to describe clinical, histopathological, radiological, molecular features patients carrying recessive variants in . Correlation clinical genetic...
Introduction: The novel Coronavirus disease (COVID-19) is caused by SARS-CoV-2 and represents the agent responsible for a respiratory metabolic with high fatality rate, remaining public health problem to this day. There has been an exacerbation of social inequalities experienced in Brazil worldwide. Notably, absence consolidated universal healthcare system contributed increased survival opportunities those affected infection manifestation COVID-19. southern region become second highest...
There are very few reports about prevalence of presenile dementia in Brazil. We reviewed files patients evaluated with early onset cognitive impairment our institution. Among 141 (61% males) there was no difference between gender by age at or first evaluation. have observed an increasing number after 50 years. The most frequent causes were: vascular (36.9%), Alzheimer's disease (20.3%) and traumatic brain injury (9.2%). among type evaluation, educational level length dementia. These results...
Background: In the phase III eculizumab for refractory generalized myasthenia gravis REGAIN study [ClinicalTrials.gov identifier: NCT01997229] and its open-label extension (OLE) NCT02301624], patients with treatment-refractory antiacetylcholine receptor antibody-positive had clinically meaningful improvements versus placebo. This subgroup analysis evaluated data from a recent history of chronic intravenous immunoglobulin (IVIg) use before entry. Methods: The comprised who received IVIg at...
Abstract Duchenne muscular dystrophy (DMD) occurs due to genetic mutations that lead a deficiency in dystrophin production and consequent progressive degeneration of skeletal muscle fibres, through oxidative stress an exacerbated inflammatory process. The flavonoid trilobatin (TLB) demonstrates antioxidant anti‐inflammatory potential. Its high safety profile effective action make it potent therapy for the process dystrophic myonecrosis. Thus, we sought investigate TLB on damage DMD model,...
There are few epidemiologic studies concerning Guillain-Barré syndrome (GBS). Due to difficulties with definition and lack of a standard diagnostic test reference, GBS is not easy study epidemiologically. We evaluate some epidemiological features in sample cases treated at tertiary hospital São Paulo, Brazil.We retrospectively reviewed all hospitalization Santa Marcelina hospital, over the period January 1995 through December 2002.Ninety-five were included this study. Fifty-five men forty...
Abstract We examined nerve biopsies from 24 patients with Charcot‐Marie‐Tooth disease type 1A (CMT1A) and proven 17p11.2‐12 duplication. There were seven males 17 females a mean age of 27.85 ± 18.95 years at the time biopsy. A family history consistent dominant inheritance was present in patients. Clinical features classical 16 atypical other eight: one had calf hypertrophy; two Roussy–Levy syndrome; subacute inflammatory demyelinating polyneuropathy 11 earlier presented relapse on form...
Introduction: depression, besides causing great psychological distress, may lead to poor academic performance and social relationships. Objective: examine the prevalence of depressive symptoms in medical students from a northeastern region Brazil. Methods: population comprised 1024 first twelfth semesters two schools Cariri, Ceará, We used questionnaire on sociodemographic characteristics Beck Depression Inventory II version. Results: this for diagnosis depression was 28.8%.652 (63.7%)...
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of open-label extension (NCT02301624), eculizumab's efficacy and safety were assessed 11 Japanese 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized gravis. For who had received placebo during REGAIN, treatment resulted...
Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central peripherical nervous systems. A considerable amount of publications have been made recent years, although cannabis has known for over a thousand years. Scientific Departments from Brazilian Academy Neurology described evidence medical use their areas. Literature is constantly changing, possible new can emerge next days or months. Prescription these substances must be...
Background: Protein aggregate myopathies (PAM) represent a group of familial or sporadic neuromuscular conditions with marked clinical and genetic heterogeneity that occur in children adults. Familial PAM includes myofibrillar defined by the presence desmin-positive protein aggregates degenerative intermyofibrillar network changes. is often caused dysfunctional genes, such as DES, PLEC 1, CRYAB, FLNC, MYOT, ZASP, BAG3, FHL1, DNAJB6. Objective: To retrospectively analyze mutations...
Introduction: in Brazil, the first case of COVID-19 was confirmed on February 26, 2020 As March 17, 2023, Ministry Health recorded 699,634 deaths from COVID-19, with a fatality rate 1.9%. The impact pandemic Brazil socioeconomic and health system spheres reflection major regional differences. Objective: to analyze mortality, incidence lethality due states Paraná Santa Catarina, southern Brazil. Methods: this is an ecological time series study using official Brazilian secondary data for cases...
Introduction: Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) or UT is a medicinal plant with antiviral, antimutagenic, anti-inflammatory and antioxidant properties. Duchenne muscular dystrophy (DMD) severe muscle wasting disease caused by mutations in the dystrophin gene; this deficiency leads to sarcolemma instability, inflammation, degeneration fibrosis. Objective: Considering importance of inflammation progression activity UT, present study we evaluated whether oral...
Abstract Limb‐girdle muscular dystrophy type 2G/R7 (LGMD2G/R7) is an ultra‐rare condition initially identified within the Brazilian population. We aimed to expand clinical and genetic information about this disease, including its worldwide distribution. A multicenter historical cohort study was performed at 13 centers in Brazil which data from index cases their affected relatives consecutive families with LGMD2G/R7 were reviewed July 2017 August 2023. Additionally, a systematic literature...