A5049862693- T-cell and Retrovirus Studies
- Long-Term Effects of COVID-19
- Vector-Borne Animal Diseases
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Full-Duplex Wireless Communications
- Infectious Encephalopathies and Encephalitis
- Migraine and Headache Studies
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- Fungal Infections and Studies
- Animal Disease Management and Epidemiology
- Trigeminal Neuralgia and Treatments
- Plant Virus Research Studies
- Multiple Sclerosis Research Studies
- Virology and Viral Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Plant Pathogens and Fungal Diseases
- Facial Nerve Paralysis Treatment and Research
- Olfactory and Sensory Function Studies
- Brucella: diagnosis, epidemiology, treatment
- Sarcoidosis and Beryllium Toxicity Research
Fundação Oswaldo Cruz
2008-2024
Instituto Evandro Chagas
2011-2022
Ministério da Saúde
2009-2022
Universidade Federal Fluminense
2003-2006
Hospital de Clínicas
2005
Brazilian Institute of Neuropsychology and Behaviour
2002
ObjectivesTo analyze the cerebrospinal fluid (CSF) of patients with SARS-CoV-2 infection and neurological manifestations to provide evidence for understanding mechanisms associated central nervous system (CNS) involvement in COVID-19.MethodsPatients (n = 58) were grouped according their main presentation: headache 14); encephalopathy 24); inflammatory diseases, including meningoencephalitis 4), acute myelitis 3), meningitis 2), disseminated encephalomyelitis (ADEM) encephalitis neuromyelitis...
We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating viral clearance precede involvement. This finding points to need for development more sensitive molecular tests and investigation other neurotropic pathogens exclude concurrent neuroinfection.
Patients with coronavirus disease 2019 (COVID-19) can present distinct neurological manifestations. This study shows that inflammatory diseases were associated increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was high serum CXCL8, active tumor growth factor β1. Inflammatory syndromes central nervous system COVID-19 appear early, as a parainfectious process without...
Background Headache is a frequent complaint in COVID-19 patients. However, no detailed information on headache characteristics provided these reports. Our objective to describe the of and cerebrospinal fluid (CSF) profile patients, highlighting cases isolated intracranial hypertension. Methods In this cross-sectional study, we selected patients who underwent lumbar puncture due neurological complaints from April May 2020. We reviewed clinical, imaging, laboratory data with refractory absence...
Neurobrucellosis is caused by bacteria of the genus Brucella and responsible for several clinical manifestations, making diagnosis challenging. The most common route infection through consumption unpasteurized or raw dairy products such as fresh milk, butter, cheese. As neurological complications can develop chronically, they are frequently misdiagnosed other infections, tuberculosis. This report reviews diagnostic approach, treatment, prognosis neurobrucellosis, illustrating a case chronic...
Polyomavirus JC (JCPyV) is largely excreted by the human population through urinary route and has been recognized as a potential viral marker for waste contamination. This study aims to investigate dissemination of JCPyV in water from sewage treatment plant (STP) located Rio de Janeiro, Brazil, describe prevalence subtypes currently present this population. Raw treated samples were collected bimonthly during one year, examined presence using nested polymerase chain reaction (nPCR)...
Meningeal sporotrichosis is rare and occurs predominantly in immunosuppressed individuals. This retrospective study explored clinical laboratory characteristics, treatment, prognosis of patients with disseminated who underwent lumbar puncture (LP) at a Brazilian reference center from 1999 to 2020. Kaplan-Meier Cox regression models were used estimate overall survival hazard ratios. Among 57 enrolled patients, 17 had meningitis. Fifteen (88.2%) HIV infection, 6 them, neurological...
Background and Objectives.—Antidepressants are often used to treat chronic daily headache disorders such as transformed migraine, in part because of the high prevalence associated mood disorder. We conducted this study evaluate efficacy tolerability combined treatment with amitriptyline fluoxetine compared alone for due migraine. Patients Methods.—Thirty‐nine patients, 26 women 13 men, aged 20 69 years (mean, 36.4; SD, 2.5) who fulfilled criteria migraine proposed by Silberstein et al were...
INTRODUCTION: Neuroparacoccidioidomycosis (NPCM) is a term used to describe the invasion of central nervous system by pathogenic fungus Paracoccidioides brasiliensis. NPCM has been described sporadically in some case reports and small series, with little or no focus on treatment outcome long-term follow-up. METHODS: All patients from January 1991 December 2006 were analyzed followed until 2009. RESULTS: Fourteen (3.8%) cases identified out 367 paracoccidioidomycosis (PCM). A combination oral...
Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease due to axonal damage of the corticospinal secondary an inflammatory response against infected T-cells. In present work, we aimed evaluate biomarkers neurodegeneration and neuroinflammation in definition HAM/TSP prognosis. Neurofilament light (NfL) phosphorylated heavy (pNfH) chains, total Tau protein, cellular prion protein (PrPc), chemokines, neopterin were...
HIV-associated neurocognitive disorders (HAND) remain prevalent in highly active antiretroviral therapy (HAART) era. Tests to detect HAND are needed for early diagnosis and treatment. Validity of International HIV Dementia Scale (IHDS) has been determined different countries. The aims this study were validate IHDS a Brazilian cohort HIV-patients verify if can be reliably administered by non-clinician health professional. One hundred eighty-seven (187) patients submitted full...
Although several neurological syndromes have been described in COVID-19, little is known about cognitive dysfunction in this setting. The social isolation, such as we are experiencing now due to the SARSCoV-2 pandemic, a signifcant limitation assessment in these patients. Thus, alternative methods assess function in large, community-dispersed populations containing an unknown proportion of individuals with impairment desirable. Additionally, screening must be inexpensive and accessible...
Laboratory diagnosis of human T-lymphotropic viruses (HTLV) 1 and 2 infection is performed by serological screening further confirmation with or molecular assays. Thus, we developed a loop-mediated isothermal nucleic acid amplification (LAMP) assay for the detection HTLV-1/2 in blood samples. The sensitivity accuracy LAMP were defined DNA samples from individuals infected HTLV-1 (n = 125), HTLV-2 19), coinfected HIV 82), compared real-time polymerase chain reaction (qPCR) PCR-restriction...
HIV-individuals are at risk for human T-lymphotropic virus (HTLV) coinfection and neurological diseases. Little is known about the impact of HAART among coinfected patients. In this study, 47 out 428 HIV individuals were with HTLV (10.9%). Coinfection was an independent variable associated outcome (odds ratio 8.73). myelopathy [chi square (X2) = 93, P < 0.001], peripheral neuropathy (X2 6.5, 0.01), hepatitis C infection 36.5, 0.001). did not appear to protect against diseases had no on proviral load.
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease that leads to motor impairment due chronic inflammatory process in the central nervous system (CNS). However, HAM/TSP pathogenesis not completely clear, and biomarkers define prognosis are still necessary. Thus, we aimed identify for potential mechanisms involved development. To end, concentrations of VILIP-1, BDNF, VEGF, β-NGF, TGF-β1, fractalkine/CX3CL1, IL-6, IL-18, TNF-α, soluble forms...
Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central peripherical nervous systems. A considerable amount of publications have been made recent years, although cannabis has known for over a thousand years. Scientific Departments from Brazilian Academy Neurology described evidence medical use their areas. Literature is constantly changing, possible new can emerge next days or months. Prescription these substances must be...