A5049567525- Poxvirus research and outbreaks
- Mosquito-borne diseases and control
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Bacillus and Francisella bacterial research
- Metabolomics and Mass Spectrometry Studies
- Biomedical Research and Pathophysiology
- Viral Infections and Vectors
- Chronic Kidney Disease and Diabetes
- interferon and immune responses
- COVID-19 diagnosis using AI
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Dialysis and Renal Disease Management
- Malaria Research and Control
- Long-Term Effects of COVID-19
- Brucella: diagnosis, epidemiology, treatment
- Sarcoidosis and Beryllium Toxicity Research
- Asthma and respiratory diseases
Imperial College Healthcare NHS Trust
2020-2025
Imperial College London
2020-2024
Hammersmith Hospital
2020-2021
St Mary's Hospital
2021
National Institute for Health Research
2018-2020
University of California, San Diego
1998-2020
University of California San Diego Medical Center
2007-2020
University of Liverpool
2018-2020
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2018-2020
Apollo Hospitals
2018
During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya caused outbreaks since 2014 associated disease rarely reported here. We investigated with acute disorders for Zika, chikungunya and dengue, another arbovirus circulating Brazil.We studied who had developed a new condition following suspected infection...
BackgroundSince 2015, the arthropod-borne viruses (arboviruses) Zika and chikungunya have spread across Americas causing outbreaks, accompanied by increases in immune-mediated infectious neurological disease. The spectrum of manifestations linked to these viruses, importance dual infection, are not known fully. We aimed investigate whether presentations differed according infecting arbovirus, patients with infection had a different disease or severity.MethodsWe report prospective...
Neurobrucellosis is caused by bacteria of the genus Brucella and responsible for several clinical manifestations, making diagnosis challenging. The most common route infection through consumption unpasteurized or raw dairy products such as fresh milk, butter, cheese. As neurological complications can develop chronically, they are frequently misdiagnosed other infections, tuberculosis. This report reviews diagnostic approach, treatment, prognosis neurobrucellosis, illustrating a case chronic...
In early 2022, a cluster of monkeypox virus (MPXV) infection (mpox) cases were identified within the UK with no prior travel history to MPXV-endemic regions. Subsequently, case numbers exceeding 80,000 reported worldwide, primarily affecting gay, bisexual, and other men who have sex (GBMSM). Public health agencies worldwide offered IMVANEX Smallpox vaccination these individuals at high-risk provide protection limit spread MPXV. We developed comprehensive array ELISAs study poxvirus-induced...
In May, 2022, the first global outbreak of mpox (formerly known as monkeypox) occurred. response, public health agencies in UK have made smallpox vaccines available to individuals at highest risk infection. With cases still being detected globally, novel tools are required aid with diagnosis, serosurveillance, and evaluation immune responses following infection immunisation current new vaccine candidates. Here, we describe development a multiplexed immunoassay, MpoxPlex, able measure IgG 12...
ObjectiveTo determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, anti-glycolipid antibody signature, and role other circulating arthropod-borne viruses, we describe a cohort GBS patients identified during ZIKV chikungunya (CHIKV) outbreaks in Northeast Brazil.MethodsWe prospectively recruited from regional neurology center Brazil between December 2014 February 2017. Serum CSF were tested for ZIKV, CHIKV, dengue (DENV), by RT-PCR antibodies,...
Emergency admissions for infection often lack initial diagnostic certainty. COVID-19 has highlighted a need novel approaches to indicate likelihood of viral in pandemic setting. We aimed derive and validate blood transcriptional signature detect infections, including COVID-19, among adults with suspected who presented the emergency department.
Acute Kidney Injury (AKI) is a complex disorder for which currently there no accepted definition. We describe an initiative to develop uniform standards defining and classifying AKI establish forum multidisciplinary interaction improve care patients with, or at risk AKI. Members representing key societies in critical nephrology along with additional experts adult pediatric participated 2-day conference Amsterdam September 2005 draft consensus recommendations diagnosing staging This report...
There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.Using untargeted high-resolution liquid chromatography coupled with mass spectrometry, we compared the admission serum metabolome of emergency department patients infections (including COVID-19), bacterial infections, inflammatory conditions, healthy controls. Sera from an independent cohort admitted or underwent profiling...
Abstract In the summer of 2022, a large outbreak Monkeypox virus (MPXV) cases occurred globally. By December total 3,582 Mpox had been confirmed within UK. As result, Modified Vaccinia Ankara-Bavarian Nordic (“IMVANEX”) vaccine was offered to high-risk groups protect against spread virus. This led development multiple serological assays aid current understanding immunology. study assessed performance multiplexed solid-phase electrochemiluminescence (Meso Scale Discovery (MSD)) immunoassay...
Background Kidney disease is prevalent in low-resource settings worldwide, but tests for its diagnosis are often unavailable. The saliva urea nitrogen (SUN) dipstick a laboratory and electricity independent tool, which may be used the detection of kidney disease. We investigated feasibility performance use diagnosing community Africa. Methods Adult patients at increased risk presenting to three health centres, rural district hospital central Malawi were recruited between October 2016...
Abstract In early 2022, a cluster of Monkeypox (now termed MPOX) virus (MPXV) cases were identified within the UK with no prior travel history to MPXV-endemic regions, suggesting localised transmission MPXV UK. Subsequently, in several other non-endemic countries and currently exceed 80,000 worldwide, primarily affecting gay, bisexual, men who have sex men. Public health agencies worldwide offered IMVANEX Smallpox vaccination these individuals provide protection limit spread MPXV. We...
Abstract The summer of 2022 saw the first global outbreak Mpox disease (formerly ‘monkeypox’), primarily within gay, bisexual, and other men who have sex with (GBMSM). In response, public health agencies in UK offered smallpox vaccines to those individuals deemed at highest risk infection. With cases still being detected globally, novel tools are required aid diagnosis, serosurveillance evaluation immune responses following infection vaccination. Here, we describe development a multiplexed...
The chemical analysis of blood products (plasma and serum) is commonplace in metabolic phenotyping studies. diversity analytes characterized by varying physico-chemical properties, stability, solubility presents an analytical challenge when attempting to achieve comprehensive analyte coverage liquid chromatography mass spectrometry (LC-MS). While reversed-phase (RPC) lipid does not suffer from the presence small molecules eluting mostly early chromatogram, RPC-based low-molecular-weight...
No AccessJournal of UrologyUrological Survey: Abstracts: Adrenal, Hypertension, Renal Physiology and Failure1 Dec 1998Continuous Replacement Therapies in the Acute Failure Setting: Current Concepts R.L. Mehta MehtaR.L. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62323-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Continuous Concepts." The Journal Urology, 160(6...
Other Types| February 28 2005 The 10th International Conference on Continuous Renal Replacement Therapies (CRRT): March 10–12, 2005, San Diego, Calif. Subject Area: Nephrology R.L. Mehta Search for other works by this author on: This Site PubMed Google Scholar Blood Purif (2005) 23 (2): 149–174. https://doi.org/10.1159/000083654 Article history Published Online: Content Tools Views Icon contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn...
Purpose: To report our experience of using Endobronchial ultrasound-guided transbronchial lymph node aspiration (EBUS-TBNA) in assessing the etiology uveitis from two tertiary eye-care centers India. Materials & Methods: Retrospective interventional case series. Results: A total 99 patients who underwent EBUS-TBNA were included study. Mycobacterium tuberculosis (MTb) was detected on culture 5 cases, 3 cases by polymerase chain reaction and caseating granulomas 25 cases. None these had any...
Refractory coeliac disease (RCD) is characterised by recurrent or persistent malabsorptive symptoms and villous atrophy, despite strict adherence to a gluten-free diet for at least 6 months where other causes of malabsorption including malignancy have been excluded. There limited evidence guidance on the effective management these patients. We describe case severe RCD in our hospital, with controlled effectively only total parenteral nutrition (TPN). This 68-year-old woman initially...