A5100426854- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Myeloid Leukemia Research
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- Venous Thromboembolism Diagnosis and Management
- Advancements in Semiconductor Devices and Circuit Design
- Phagocytosis and Immune Regulation
- Neuropeptides and Animal Physiology
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Ferroptosis and cancer prognosis
Huashan Hospital
2022-2025
Fudan University
2022-2025
National Health and Family Planning Commission
2025
Wuhan Third Hospital
2025
Crown Bioscience (China)
2021-2024
Nanjing University of Chinese Medicine
2020-2024
Jiangxi University of Traditional Chinese Medicine
2024
North China University of Science and Technology
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Abstract The growth and sustainable development of humanity is heavily dependent upon molecular nitrogen (N 2 ) fixation. Herein we discover ambient catalyst-free disproportionation N by water plasma which occurs via the distinctive HONH-HNOH +• intermediate to yield economically valuable nitroxyl (HNO) hydroxylamine (NH OH) products. Calculations suggest that reaction prompted coordination electronically excited with dimer radical cation, (H O) , in its two-center-three-electron...
T cells expressing chimeric antigen receptors, especially CD19 CAR-T have exhibited effective antitumor activities in B cell malignancies, but due to several factors such as escape effects and tumor microenvironment, their curative potential hepatocellular carcinoma has not been encouraging. To reduce the risk of carcinoma, this study was design construct a bispecific CAR targeting c-Met PD-L1. c-Met/PD-L1 were obtained by lentiviral transfection, transfection efficiency monitored flow...
Atezolizumab plus bevacizumab as a first-line therapy for patients with unresectable or metastatic hepatocellular carcinoma has been shown to improve overall and progression-free survival compared standard sorafenib treatment. However, because of the high cost atezolizumab bevacizumab, assessment its value by considering both efficacy is needed.To evaluate cost-effectiveness vs from US payer perspective.This economic evaluation was performed June through September 2020, 6-year investment...
Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin associated with HIV infection and immunodeficiency. However, PBL can also be seen immunocompetent individuals in recent studies. was characterized by distinct clinical pathological features, such as plasmablastic morphology universal expression of plasma cell markers. The clinicopathologic features were different between HIV-negative HIV-positive patients. Gene analysis identified the unique molecular feature PBL, including frequent...
Cancer metastasis is the main cause of chemotherapeutic failure. Inhibiting activity matrix metalloproteinases (MMPs) a common strategy for reducing metastasis. However, broad-spectrum MMP-inhibitors (MMPI) may undesired side effects. Here, we screened selective MMP2 inhibitor (CCKIGLFRWR) and linked it with doxorubicin (DOX) to produce an amphiphilic peptide-drug conjugate (PDC). Then novel core-shell nanoparticles were self-assembled from PDC core modified polylysine (MPL) shell. When...
Background:The prognostic nutritional index (PNI) is related to the prognosis of multiple malignancies.This study investigated whether PNI has value in advanced non-small cell lung cancer (NSCLC) patients treated with programmed death 1 (PD-1) inhibitors.Methods: We retrospectively analyzed NSCLC PD-1 inhibitors from July 2018 December 2019.Pretreatment was calculated by peripheral lymphocyte count and serum albumin level, cut-off determined.Subsequently, we relationship between early...
Objective This study aimed to evaluate hepatitis B virus (HBV) reactivation and its effect on tumor response survival outcomes in patients with HBV-related advanced hepatocellular carcinoma (HCC) undergoing lenvatinib plus camrelizumab treatment. Methods 216 HCC receiving were enrolled. Overall (OS), progression-free survival, evaluated. Univariate multivariate analyses performed determine risk factors for HBV reactivation. Results occurred 24 (11.1%). It was associated poor these patients....
We aim to evaluate the safety and pharmacokinetic (PK) properties of cefiderocol in Chinese participants, following single subsequent multiple administrations 2 g q8h with 3-h intravenous infusion, predict its efficacy for treatment Gram-negative bacilli (GNB) infection based on PK/pharmacodynamic (PD) analysis. This was an open-label, single-center, single- multiple-dose phase I study, conducted from September 2022 October 2022, 12 eligible healthy adults (6 men 6 women). The PK profiles...
Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensively to test various investigational therapies, including population-trials as surrogate subjects in vivo. PDOs recognized vitro surrogates patients amenable high-throughput screening (HTS). We built a biobank carcinoma PDX-derived organoids...
Abstract This study aimed to investigate the effect of comprehensive education and care (CEC) program on anxiety, depression, quality life, survival in patients with hepatocellular carcinoma (HCC) who underwent surgical resection. Totally 136 HCC hepatectomy were randomly assigned CEC group control as 1:1 ratio. received health education, psychological nursing, caring activity, telephone condolence, whereas basic rehabilitation for 12 months. Anxiety depression assessed by Hospital...
Background: Lung cancer is the leading cause of death. Platelet-related indictors, including platelet count, plateletcrit, mean volume, and distribution width, not only associate with morphology functions but also correlate tumor development metastasis. In present study, we investigated values platelet-related indictors in prognosis evaluation resectable lung cancers. Methods: total, 101 patients were recruited this study. Patients divided into 2 groups according to median pretreatment...
Multi-disciplinary team (MDT) collaboration enables hepatocellular carcinoma (HCC) patients to achieve better survival through precise diagnosis and individualized treatment. This study aimed further investigate the effect of MDT care program (MDT-CP) on quality life (QoL), anxiety depression in HCC after surgery.Totally, 150 postoperative were enrolled randomized a 1:1 ratio into MDT-CP group (N = 76) receive for 6 months normal (N-CP) 74) routine months.Quality Life Questionnaire-Core 30...
Abstract Background The five-year cumulative incidence rate in patients diagnosed with stage I small-cell lung cancer (SCLC) who were instructed to undergo surgery was from 40 60%.The death competition influence the accuracy of classical survival analyses. aim study is investigate mortality presence competing risks according a proportional hazards model, and establish risk nomogram predict probabilities both cause-specific resulting other causes. Methods subjects SCLC ICD-O-3. First,...
Background Small‐cell lung cancer (SCLC) is one of the most aggressive types cancer. The prognosis for SCLC patients depends on many factors. intent this study was to construct a nomogram model predict mortality extensive‐stage SCLC. Methods Original data collected from Surveillance, Epidemiology, and End Results (SEER) database National Cancer Institute in United States. A prognostic constructed death probability total 16 554 2004 2014 SEER were included study. Gender, race, age, TNM...
Small-cell lung cancer (SCLC) is an aggressive high-grade neuroendocrine tumor with limited treatment strategies. Programmed death 1 (PD-1) and its ligand (PD-L1), delta-like ligand-3 (DLL-3), poly ADP-ribose polymerase (PARP) inhibitors have shed light on the of extensive stage-SCLC. However, expression prognostic role PD-L1, DLL-3, PARP are barely explored in surgically resected stage-SCLC (LS-SCLC).We retrospectively reviewed 404 SCLC patients from 2011 to 2018 First Affiliated Hospital...
Pancreatic adenocarcinoma is one of the leading causes cancer-related death worldwide. Since little clinical symptoms were shown in early period pancreatic adenocarcinoma, most patients found to carry metastases when diagnosis. The lack effective diagnosis biomarkers and therapeutic targets makes difficult screen cure. fundamental problem we know very about regulatory mechanisms during carcinogenesis. Here, employed weighted gene co-expression network analysis (WGCNA) build interaction using...
Endometrial carcinoma (EC) is one of the most common gynecological cancers with a poor prognosis. Therefore, clarifying details molecular mechanisms great importance for EC diagnosis and clinical management. Interferon‑stimulated gene 15 (ISG15) plays an important role in development various cancers. However, its remains unclear. High ISG15 expression was observed EC, which associated outcomes pathological stage patients thus representing promising marker progression. Further exploratory...
Background: Gliomas are the most prevalent primary brain tumors, and patients typically exhibit poor prognoses. Increasing evidence suggests that telomere maintenance mechanisms play a crucial role in glioma development. However, prognostic value of telomere-related genes remains uncertain. This study aimed to construct model further elucidate potential association between two. Methods: We acquired RNA-seq data for low-grade (LGG) glioblastoma (GBM), along with corresponding clinical...
CD19-modified CAR-T cells greatly influence responses in patients with relapsed/refractory acute lymphoblastic leukemia (ALL). However, recurrence remains a challenge, and reinfusion of is not always effective. Sequential infusion humanized CD22-modified may overcome this issue induce remission.We examined treatment sequential patient relapsed ALL previously exposed to murine-derived anti-CD19 cells.At ~6 weeks after treatment, repeated bone marrow smear flow cytometry analysis revealed no...