A5112945019- Inflammatory Biomarkers in Disease Prognosis
- Dementia and Cognitive Impairment Research
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Blood Pressure and Hypertension Studies
- Neurobiology of Language and Bilingualism
- Voice and Speech Disorders
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Chemokine receptors and signaling
- Language Development and Disorders
- Liver Disease Diagnosis and Treatment
- Beetle Biology and Toxicology Studies
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Non-Invasive Vital Sign Monitoring
- Phagocytosis and Immune Regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Emotion and Mood Recognition
- Protein Hydrolysis and Bioactive Peptides
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Stuttering Research and Treatment
Soochow University
2015-2025
First Affiliated Hospital of Soochow University
2015-2025
Anhui Agricultural University
2023-2024
Guangdong Pharmaceutical University
2023-2024
Dalian University of Technology
2023-2024
China Medical University
2015-2024
Liaoning Cancer Hospital & Institute
2017-2024
Anhui Medical University
2024
Cambridge Cognition (United Kingdom)
2024
Ministry of Agriculture and Rural Affairs
2023
VEGF/VEGFR2 pathway is the central therapeutic target in anti-angiogenic treatment multiple cancers. However, little work has been carried out concerning pro-malignancy functions of VEGFR2 that are independent its pro-angiogenesis effects gastric cancer. Here, we demonstrated up-regulation cancer tissues was a prognostic marker for poor disease-free survival and overall patients.Immunohistochemistry used to detect VTN expressions specimens. Kaplan-Meier curves were constructed analysis....
Anti-angiogenic therapy has been successfully applied to treat colorectal cancer (CRC). Ginsenoside Rg3, derived from the Chinese herb ginseng, anti-vascularization effects and can inhibit tumor growth metastasis, sensitize cells chemotherapy. Therefore, in present study, we investigated whether Rg3 could be appropriate for CRC treatment. Growth of was assessed by an MTT (methyl thiazolyl tetrazolium) assay vitro using orthotopic xenograft models vivo. mRNA expression evaluated real-time...
Abstract Background Language impairment is an important marker of neurodegenerative disorders. Despite this, there no universal system terminology used to describe these impairments and large inter-rater variability can exist between clinicians assessing language. The use natural language processing (NLP) automated speech analysis (ASA) emerging as a novel potentially more objective method assess in individuals with mild cognitive (MCI) Alzheimer’s dementia (AD). No studies have analyzed how...
Despite new developments in cancer therapy, chemotherapy and radiotherapy remain the cornerstone of breast treatment. Therefore, finding ways to reduce toxicity increase sensitivity is particularly important. Tumor necrosis factor alpha (TNF-α) exerts multiple functions cell proliferation, differentiation apoptosis. In present study, we investigated whether TNF-α could enhance effect against cells. Cell growth was determined by MTT assay vitro, using nude mouse tumor xenograft model vivo....
The main purpose of this study was to isolate and identify Angiotensin Converting Enzyme (ACE) inhibitory peptides (IPs) from black soybean protein hydrolysate compare the activity between single mixed peptides. Black hydrolyzed, desalted, separated by size-exclusion ultrafiltration G-15 Sephadex column. A total 31 were identified nano-HPLC-ESI-MS/MS. 7 screened molecular docking, only three ACEIPs after synthetized bioactive verified, namely KDFPPR (IC50 = 7.91 ± 0.27 mg/mL), VVPPGHPF 12.13...
Detecting early signs of cognitive decline is crucial for detection and treatment Alzheimer's Disease. Most the current screening tools Disease represent a significant burden, requiring invasive procedures, or intensive costly clinical testing. Recent findings have highlighted changes to speech language patterns that occur in Disease, may be detectable prior diagnosis. Automated assess been developed can used on smartphone tablet, from one's home, under 10 min. In this study, we present...
Cantharidin (CTD) is a promising anticancer drug; however, its dosage limited by hepatotoxicity. We previously showed that Astragalus polysaccharides (APS) effectively improved chemical liver injury. In this study, we established CTD-induced subacute injury mouse model and examined the effects of APS on weight, indexes, histopathology, serum biochemical indexes metabolism. Compared with control group, mice in CTD group had obvious damage, which was partially prevented APS. Metabolomics...
740 Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with poor prognosis worldwide. Chidamide, a subtype-selective histone deacetylase (HDAC) inhibitor, has significant anti-tumor effects and extensive synergistic immunotherapy. Envafolimab light-chain deficient PD-L1 antibody. Here we conducted single-arm, multicenter, prospective phase Ⅱ clinical study (ChiCTR2200058431) to evaluate efficacy safety Chidamide plus combined S-1 as second-line treatment in...
There is increasing interest in using computational speech and language analysis for the objective assessment of symptom severity schizophrenia spectrum disorders (SSD), including negative severity. However, extent to which antipsychotic side effects influence markers symptoms unclear. This study investigated associations between severity, examined whether features are associated with dose extrapyramidal (EPS). Sixty-seven participants SSD completed speech-focused tasks clinical assessment....
Objective: SARS-CoV-2 (originally named COVID-2019) pneumonia is currently prevalent worldwide.The number of cases has increased rapidly but the auscultatory characteristics affected patients and how to use it predict who most likely survive or die are not available.This study aims describe its clinical relativity by using a wireless stethoscope.Material methods: A cross-sectional, observational, single-center case series 30 consecutive hospitalized with confirmed at Leishenshan Hospital in...
Abstract Pancreatic cancer is one of the most lethal gastrointestinal tumours, common pathological type pancreatic adenocarcinoma (PAAD). In recent year, immune imbalanced in tumour microenvironment has been shown to play an important role evolution tumours progression, and efficacy immunotherapy gradually demonstrated clinical practice. this study, we propose construct immune‐related prognostic risk model based on genes MMP14 INHBA expression that can assess prognosis patients identify...
Speech and language changes occur in Alzheimer's disease (AD), but few studies have characterized their longitudinal course. We analyzed open-ended speech samples from a prodromal-to-mild AD cohort to develop novel composite score characterize progressive changes. Participant the Clinical Dementia Rating (CDR) interview was compute metrics reflecting characteristics. determined aspects of that exhibited significant change over 18 months. Nine acoustic linguistic measures were combined create...
Sleep can affect nonalcoholic fatty liver disease (NAFLD). We investigated the association between sleep duration, quality, and NAFLD. From January to December 2018, 1,073 patients (age: 37.94 ± 10.88, Body Mass Index (BMI): 22.85 3.27) were enrolled. Pittsburgh Quality Questionnaire Munich Chronotype used assess habits. Ultrasonography was diagnose Multivariate logistic regression models calculate odds ratio (OR) 95% confidence interval (CI) of risk NAFLD by different types duration...
Cantharidin, one of the active components mylabris, is believed to have antitumor activity. Cantharidin selectively inhibits protein phosphatase 2A (PP2A), which can repress multiple oncogenic kinases (ERK, JNK, PKC, and NF-κB). Researches in vitro shown that cantharidin suppresses cell viability metastasis pancreatic cancer cells. This study aims investigate effects on xenografts vivo. Xenograft models were established using cells stably expressing luciferase. growth was evaluated by living...
Colorectal cancer (CRC) represents the third most common malignancy worldwide. The aim of present study was to investigate predictive values platelet-associated indicators, including platelet count (PLT), plateletcrit (PCT), mean volume (MPV) and distribution width (PDW) in patients with resectable CRC. current retrospective included 153 who were pathologically diagnosed divided into two groups according median value PLT, PCT, MPV or PDW. To evaluate changes PDW following resection adjuvant...
Abstract Non‐small‐cell lung cancer (NSCLC), with its aggressive biological behavior, is one of the most diagnosed cancers. Tumor‐associated inflammatory cells play important roles in interaction between chronic inflammation and cancer, however mechanisms involved are far from defined. In present study, by developing an orthotopic NSCLC mouse model based on inflammation, we proved that microenvironment accelerated growth xenografts vivo. macrophages, abundant population cells, were...
The count and classification of white blood cells (WBCs) may be used as prognostic markers in certain types cancer. present study investigated the potential counts WBCs, including lymphocytes (LYs), monocytes (MOs), neutrophils (NEs), eosinophils (EOs) basophils (BAs), prognosis resectable colorectal recruited 153 cancer cases retrospectively, which were pathologically confirmed. All patients divided into two groups, according to median value LY (low LY, ≤1.632x109/l or high >1.632x109/l),...