A5101439389- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Dendrimers and Hyperbranched Polymers
- Phagocytosis and Immune Regulation
- Drug Transport and Resistance Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- ATP Synthase and ATPases Research
- Lanthanide and Transition Metal Complexes
- Cell Adhesion Molecules Research
- Graphene and Nanomaterials Applications
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Immune cells in cancer
- Molecular Sensors and Ion Detection
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Nanocluster Synthesis and Applications
Shanghai Public Health Clinical Center
2024
Fujian Provincial Cancer Hospital
2020-2023
Fujian Medical University
2020-2023
Shenyang Pharmaceutical University
2016-2023
Jiangxi Science and Technology Normal University
2020-2021
Tongji University
2015-2019
State Council of the People's Republic of China
2018-2019
Shanghai Tenth People's Hospital
2017-2019
Chinese Academy of Sciences
2014
University of Science and Technology of China
2014
Abstract Development of multifunctional theranostic nanoplatforms with improved diagnostic sensitivity and therapeutic efficiency tumors still remains a great challenge. A unique nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer–stabilized gold nanoflowers (NFs) embedded ultrasmall iron oxide (USIO) nanoparticles (NPs) for multimode T 1 ‐weighted magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging–guided combination photothermal therapy (PTT)...
Amplifying "eat me signal" during tumor immunogenic cell death (ICD) cascade is crucial for immunotherapy. Inspired by the indispensable role of adenosine triphosphate (ATP, a necessary ICD), versatile ICD amplifier was developed chemotherapy-sensitized Doxorubicin (DOX), ATP and ferrous ions (Fe2+) were co-assembled into nanosized (ADO-Fe) through π‒π stacking coordination effect. Meanwhile, phenylboric acid-polyethylene glycol-phenylboric acid (PBA-PEG-PBA) modified on surface ADO-Fe...
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines because antigen presentation and initiation T-cell-mediated immune responses occur primarily at these locations. In this study, amphiphilic diblock copolymer poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) (PEOz-PLA) combined with carboxylterminated-Pluronic F127 was used to construct mixed micelles [carboxylated-nanoparticles (NPs)] for codelivery ovalbumin (OVA) Toll-like receptor-7 agonist CL264...
Introduction: Multidrug resistance (MDR) of breast cancer is the major challenge to successful chemotherapy while mitochondria-targeting therapy was a promising strategy overcome MDR. Materials and methods: In this study, HER-2 peptide-PEG 2000 -Schiff base-cholesterol (HPSC) derivate synthesized successfully incorporated it on surface doxorubicin (DOX)-loaded dequalinium (DQA) chloride vesicle (HPS-DQAsomes) treat drug-resistant cancer. Evaluations were performed using human cell...
The therapeutic efficacy of chemotherapy is dramatically hindered by multidrug resistance (MDR), which induced the overexpression P-glycoprotein (P-gp). codelivery an antitumor drug and siRNA effective strategy recently applied in overcoming P-gp-related MDR. In this study, a multifunctional delivery system with both pH-sensitive feature active targetability was designed, MDR1-siRNA DOX were successfully loaded. resulting carrier EphA10 antibody-conjugated doxorubicin (DOX), coloading...
Development of novel activable dual-mode T1/T2-weighted magnetic resonance (MR) contrast agents with the same composition for dynamic precision imaging tumors has been a challenging task. Here, we demonstrated strategy to prepare clustered Fe3O4 nanoparticles (NPs) redox-responsiveness tumor microenvironment achieve switchable T2/T1-weighted MR applications. In this study, first synthesized ultrasmall NPs an average size 3.3 nm and r1 relaxivity 4.3 mM–1 s–1, then cross-linked single using...
A stimuli-responsive nanoplatform achieves successful intracellular siRNA delivery due to a proton sponge effect based on poly(<sc>l</sc>-histidine) and effective gene silencing <italic>in vivo</italic>.
There are two severe obstacles in cancer immunotherapy. The first is that the low response rate challenges immune owing to immunosuppressive tumor microenvironment (ITM) and poor immunogenicity of tumor. second obstacle dense intricate pathophysiology barrier seriously restricts deep drug delivery solid tumors. A laser/glutathione (GSH)-activatable nanosystem with penetration for achieving highly efficient immunotherapy reported. core was synthesized by coordinating zinc ions GSH-activatable...
The development of new nanoplatforms with enhanced tumor accumulation for accurate diagnosis still remains a great challenge in current precision nanomedicine. Herein, we report the design stem cell-mediated delivery nanogels (NGs) loaded ultrasmall iron oxide (Fe3O4) nanoparticles (NPs) magnetic resonance (MR) imaging tumors. In this study, sodium citrate-stabilized Fe3O4 NPs size 3.16 ± 1.30 nm were first synthesized using solvothermal route, coated polyethyleneimine (PEI), and used as...
Diabetic chronic wounds remain a major clinical challenge with long-term inflammatory responses and extreme oxidative damage. Hence, pH-responsive injectable multifunctional hydrogel [Gel/CUR-FCHO/Mg (GCM) micromotors] via Schiff base reaction between gelatin benzaldehyde-grafted Pluronic F127 drug-loaded micelles (FCHO) was fabricated for the first time. Dynamic linkage endowed GCM ability to be self-healing, injectable, on-demand drug delivery at wound site. Curcumin (CUR), hydrophobic...
Polydopamine-coated magnetic mesoporous silica nanoparticles have been designed by loading ultrasmall iron oxide within hollow nanopartricles and then coating polydopamine onto the particle surface. The developed nanoplatform displayed improved colloidal stability, enhanced r1 relaxivity near infrared absorption feature, affording their use for multimodal cancer theranostics.
The formation of gold nanoparticle (Au NP)-loaded γ-polyglutamic acid (γ-PGA) nanogels (NGs) for computed tomography (CT) imaging tumors is reported. γ-PGA with carboxyl groups activated by 1-ethyl-3-[3-(dimethylamino)propyl] carbodiimide hydrochloride first emulsified to form NGs and then in situ chemically cross-linked polyethylenimine (PEI)-entrapped Au NPs partial polyethylene glycol (PEG) modification ([(Au0)200–PEI·NH2–mPEG]). formed γ-PGA–[(Au0)200–PEI·NH2–mPEG] a size 108.6 ± 19.1 nm...
A novel pH-sensitive conjugate glycyrrhetinic acid–polyethylene glycol–Schiff bond–cholesterol (GPSC) has been synthesized successfully and used to construct doxorubicin-loaded liposomes with both features active targeting ability.
At present, multidrug resistance (MDR) in cancer therapy is an international problem, which caused mostly by the overexpressed P-glycoprotein (P-gp) efflux pump.
It is generally known that, for nanoparticles in cancer therapy, sufficient tumor penetration needs a minor particle size, while long vivo circulation time larger size. hard to balance them because they are standing on either side of seesaw. To address these two different requirements, dual-responsive size-shrinking nanocluster can self-adaptively respond complicated microenvironment and transform its particulate property overcome sequential barriers reach preferable antitumor activity. The...