A5005938167- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
- Chinese history and philosophy
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Nanoparticle-Based Drug Delivery
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- vaccines and immunoinformatics approaches
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Plant biochemistry and biosynthesis
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Caching and Content Delivery
- Bone health and treatments
- Advanced Data Storage Technologies
- RNA modifications and cancer
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
Chongqing Medical University
2020-2025
China Medical University
2017-2025
Dalian University of Technology
2022-2025
Liaoning Cancer Hospital & Institute
2017-2025
Southern Medical University
2005-2025
Nanfang Hospital
2005-2025
Central China Normal University
2024
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
General Research Institute for Nonferrous Metals (China)
2024
Limonene is an important biologically active natural product widely used in the food, cosmetic, nutraceutical and pharmaceutical industries. However, low abundance of limonene plants renders their isolation from plant sources non-economically viable. Therefore, engineering microbes into microbial factories for producing fast becoming attractive alternative approach that can overcome aforementioned bottleneck to meet needs industries make production more sustainable environmentally...
Central nervous system (CNS) disorders confront significant challenges in drug delivery due to the blood-brain barrier (BBB). Inspired by rapid and precise binding of odor molecules olfactory receptors (ORs), this research uses thiolated HPMA construct nanoparticles (nanoodors) capable delivering drugs CNS via olfacto-cerebral pathway overcome obstruction. The nanoodor core is used encapsulate agomelatine (AGO), a CNS-targeting antidepressant, encapsulation efficiency exceeded 80%. A series...
Abstract Background Circular RNAs (circRNAs), a class of noncoding (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. However, there is large gap the knowledge about circDOCK1 and its biological functions osteogenic sarcoma (OS). Methods Differentially expressed OS cell lines tissues were identified circRNA microarray analysis quantitative real-time PCR (qRT–PCR). To explore actions vivo...
Abstract Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in variety of biological processes, including cartilage regeneration. However, few studies reported their potential the development osteoarthritis (OA) previously. In this study, we explored roles and underlying mechanism MSCs-EVs OA. Results Co-culture experiments revealed that could promote expression collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9)...
This study aimed to investigate the roles of adipose mesenchymal stem cell (AMSC)-derived extracellular vesicles (EVs) binding with chitosan oligosaccharides (COS) in cartilage injury, as well related mechanisms.IL-1β treatment significantly inhibited viability and migration chondrocytes enhanced apoptosis (P < 0.05), while vesicles-chitosan oligosaccharide conjugates (EVs-COS/EVs-COS conjugates) reversed changes induced by IL-1β effects were better than those 0.05). After damage, IL-1β,...
Summary The natural plant product bisabolene serves as a precursor for the production of wide range industrially relevant chemicals. However, low abundance in plants renders its isolation from sources non‐economically viable. Therefore, creation microbial cell factories supported by synthetic biology and metabolic engineering strategies presents more competitive environmentally sustainable method industrial bisabolene. In this proof‐of‐principle study, first time, we engineered oleaginous...
Limonene is an important plant natural product widely used in food and cosmetics production as well the pharmaceutical chemical industries. However, low efficiency of extraction high energy consumption synthesis limit sustainability industrial limonene production. Recently, advancement metabolic engineering synthetic biology has facilitated microbes into microbial cell factories for producing limonene. deleterious effects on cellular activity by toxicity major obstacle achieving high-titer...
Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in particle of vaccine carriers such as mesoporous silica nanoparticles (MSNs) affect this response is unknown. We prepared 50, 100, 200 nm MSNs that adsorbed ovalbumin (OVA) while modifying β-glucan enhance immunogenicity. The results...
Nowadays, more and enterprises organizations are hosting their data into the cloud, in order to reduce IT maintenance cost enhance reliability. However, facing numerous cloud vendors as well heterogenous pricing policies, customers maywell be perplexed with which cloud(s) suitable for storing what strategy is cheaper.The general status quo that usually put a single (which subject vendor lock-in risk) then simply trust luck. Based on comprehensive analysis of various state-of-the-art vendors,...
Circular RNAs (circRNAs) are recently emerged to be promising therapeutic targets of tumors. Osteosarcoma is the most prevalent primary bone tumor and third cancer in children adolescents. This study firstly analyzed circRNA microarray osteosarcoma selected circ-0001785 as object. We aimed comprehensively investigate expression pattern biological function progression osteosarcoma. Relative levels miR-1200 normal human osteoblast cell line lines were determined. Bioinformatics analyses...