Protein self-assembly into exquisite, complex, yet highly ordered architectures represents the supreme wisdom of nature. However, precise manipulation protein behavior in vitro is a great challenge. Here we report that by taking advantage cooperation metal-ion-chelating interactions and nonspecific protein-protein interactions, achieved accurate control orientation proteins their nanorings. As building block, utilized C2-symmetric sjGST-2His, variant glutathione S-transferase from...

Due to the long-standing challenge realize underwater adhesion, there are a few commercially available pressure-sensitive adhesives (PSAs), which are, however, ubiquitously used for dry adhesion. Herein, PSA is developed on basis of simple, low-cost, and easily commercial formulation, only involves copolymerization butyl acrylate (BA) acrylic acid (AA). By tuning ratios between hydrophobic BA unit H-bonding AA unit, we optimize viscoelastic properties maximize adhesion performance. The...

Dynamic covalent thermosets have emerged as a next-generation sustainable plastic that combines the advantages of traditional and thermoplastics. However, dynamic generally suffer from trade-off between strength/stiffness ductility/toughness. Herein, strategy to simultaneously strengthen toughen thermosets, incorporation hydrogen-bonded (H-bonded) cross-links into networks, is reported. We designed polyimine network cross-linked by both imine bonds H-bonds, resulting in remalleable...

Central nervous system (CNS) disorders confront significant challenges in drug delivery due to the blood-brain barrier (BBB). Inspired by rapid and precise binding of odor molecules olfactory receptors (ORs), this research uses thiolated HPMA construct nanoparticles (nanoodors) capable delivering drugs CNS via olfacto-cerebral pathway overcome obstruction. The nanoodor core is used encapsulate agomelatine (AGO), a CNS-targeting antidepressant, encapsulation efficiency exceeded 80%. A series...

Abstract It is highly desirable to develop reversible and easy‐release adhesives with high bonding strength for a broad range of substrates, while the adhesion low‐surface‐energy materials (e.g., polytetrafluoretyhylene, PTFE) challenging. Herein, substrate‐independent ionogel adhesive developed by blending an ionic liquid copolymer bearing charged segments. By regulating viscoelastic properties ionogel, cohesive can be well balanced maximize different substrates. The as‐developed exhibits...

KR-12 was grafted onto the surface of PEEK, which improved hydrophilicity material surface, promoted cell adhesion, osteogenic differentiation and osseointegration, while also endowing appreciable antibacterial activity on surface.

This study presents the Ni-ion-directed self-assembly of a C2-symmetric homodimeric enzyme into nanowires. A genetically introduced His-tag arm stretches out central structure homodimer glutathione S-transferase, which is used as linker to recruit second building block through interprotein metal coordination, forming self-assembled one-dimensional nanostructures with excellent enzymatic activity.

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is known to play a role in sensitivity temozolomide. Promoter hypermethylation of MGMT commonly used predict low expression levels gliomas, despite observed discordance between promoter methylation and levels. Here, we investigated the functional gene body cytosine modification regulating In 91 human glioblastoma samples, significant variation patients with an unmethylated promoter, higher correlating Furthermore,...

Targeting prostate cancer cells with hybrid elastin-like polypeptide/liposome nanoparticles Wei Zhang,1 Yunmei Song,1 Preethi Eldi,1 Xiuli Guo,2 John D Hayball,1,3 Sanjay Garg,1 Hugo Albrecht1 1Centre for Pharmaceutical Innovation and Development, Centre Drug Discovery Experimental Therapeutics Laboratory, Sansom Institute Health Research, School of Pharmacy Medical Sciences, University South Australia, Adelaide, SA, Australia; 2Department Pharmacology, Shandong University, Jinan, China;...

Open AccessCCS ChemistryRESEARCH ARTICLE5 Sep 2022Identification of the New Type G-Quadruplex with Multiple Vacant Sites in Human Telomeric DNA Xiaonong Zhang†, Xiaolong Kou†, Wei Zhang and Wenke Zhang† State Key Laboratory Supramolecular Structure Materials, College Chemistry, Jilin University, Changchun 130012 , Kou† *Corresponding author: E-mail Address: [email protected] https://doi.org/10.31635/ccschem.021.202101436 SectionsSupplemental MaterialAboutAbstractPDF ToolsAdd to...

Dihydroartemisinin (DHA), a plant-derived natural product, has recently been proven to be an effective therapeutic agent for cancer treatment. Nevertheless, the poor water solubility and low bioavailability of DHA seriously impede its clinical applications. Herein, simple green strategy based on self-assembly was developed synthesize carrier-free nanoparticles (NPs). The resulting nanodrug (DHA NPs) formed by molecules via hydrogen bonding hydrophobic interactions. NPs exhibited...

A synergistic effect between individual components is crucial for increasing the activity of metal/metal oxide catalysts. The greatest challenge how to control obtain enhanced catalytic performance. Through density functional theory calculations model Au/TiO2 catalysts, it suggested that there strong interaction Au nanoparticles and Ti species at edge/corner sites anatase, which favorable formation stable oxygen vacancies. Motivated by this theoretical analysis, we have rationally prepared...

Shikonin (SHK) is a potential chemotherapy drug for the treatment of breast cancer. However, poor water solubility, as well lack tumor targeting, restricts practical application SHK molecules. In addition, alone no longer sufficient current clinical treatment, and it needs to be combined with other therapeutical methods. Here, using our previously developed shikonin-disulfide bond-poly(ethylene glycol) compound (referred SHK-SS-PEG) molecule that responds reduced glutathione (GSH),...

Driven by the excitement surrounding high-temperature superconductivity in hydrides, we systematically investigated structures, electronic properties, and of ternary Y-B-H compounds using first-principles calculations combined with a genetic algorithm for structure search. Five stable phases (YBH, YBH2, YBH10, YB2H6 YB2H10) were predicted at specified pressures. Several structural building units, such as boron rings, folded chains, BH4 tetrahedrons, dumbbell-shaped B2H6, observed these...

Poly(ethylene imine) (PEI) is one of the most efficient nonviral vectors, and its binding mode/strength with double-stranded DNA (dsDNA), which still not clear, a core area transfection studies. In this work we used atomic force microscopy (AFM)-based single molecule spectroscopy (SMFS) to detect interaction between branched PEI dsDNA quantitatively by using long chain as probe. Our results indicate that binds phosphoric acid skeletons mainly via electrostatic interactions, no obvious...

Abstract The performances of NEPE (Nitrate Ester Plasticized Polyether) propellants containing 1,1 diamino‐2,2‐dinitroethylene (FOX‐7) were evaluated by means theoretical calculation, combustion, mechanical and sensitivity experiments. It was found that, the replacement Cyclotetramethylene tetranitramine (HMX) with FOX‐7 in propellants, density (ρ) maintained to be same 1.80 g cm −3 , whereas combustion temperature ( T c ) decreased from 3700 K 3592 K. meaN molecular weight gas M slightly...