A5089852629- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Pharmaceutical studies and practices
- Microbial Metabolites in Food Biotechnology
- Esophageal and GI Pathology
- Analytical Methods in Pharmaceuticals
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
- Nail Diseases and Treatments
- Nonmelanoma Skin Cancer Studies
- Breastfeeding Practices and Influences
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Curcumin's Biomedical Applications
- Cannabis and Cannabinoid Research
- Clostridium difficile and Clostridium perfringens research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Essential Oils and Antimicrobial Activity
University of South Australia
2016-2025
The University of Adelaide
2015-2020
Hanyang University
2013
China Pharmaceutical University
2008
Monash University
2002
There has been little understanding of acidification functionality in wound healing, highlighting the need to study efficacy on closure and cellular activity non-infected wounds. This is focused establishing healing potential Acidic buffers, constituting either phosphoric or citric acid, were employed modify physiological pH full-thickness excisional murine Acidification by acidic buffers was found be an effective strategy improve healing. A significant improvement parameters observed as...
We report on the fabrication and characterization of dry hybrid lipid−silica nanoparticle based microcapsules with an internal porous matrix structure for encapsulation poorly soluble drugs, their delivery properties (in vitro release lipolysis in vivo pharmacokinetics demonstrated indomethacin as a model drug). Microcapsules were prepared by spray drying Pickering o/w emulsions containing either negatively or positively charged lipophilic surfactant oil phase hydrophilic silica...
Cannabidiol (CBD) has demonstrated therapeutic potential in treating epilepsy, multiple sclerosis, Alzheimer’s, Parkinson’s, and Crohn’s diseases. Despite its promising effects analgesic, anti-inflammatory, anxiolytic properties, oral CBD’s full is hindered by poor water solubility (0.7–10 μg/mL), low permeability, chemical instability. This study aimed to enhance dissolution, stability, gastrointestinal (GI) permeability forming a CBD–phospholipid complex (CBD-PLC). We hypothesised that...
Inulin-based hydrogels are useful carriers for the delivery of drugs in colon-targeted system and other biomedical applications. In this project, inulin were fabricated by crosslinking oxidized with adipic acid dihydrazide (AAD) without use a catalyst or initiator. The physicochemical properties obtained further characterized using different techniques, such as swelling experiments, vitro drug release, degradation, biocompatibility tests. was confirmed Fourier transform infrared spectroscopy...
The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness urinary symptoms), sexual dysfunction, mood, sleep disturbance often last longer than decade. Furthermore, reductions in level increase risks chronic complications such as osteoporosis, cardiovascular disease, cognitive decline among others, thereby affecting quality...
Imiquimod (IMQ) is an immunomodulating drug that approved for the treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and perianal warts. However, IMQ cream (Aldara®) has several drawbacks including poor skin permeation, local toxicity, compromised patient compliance as a topical pharmacological option.Our research aimed to develop optimize nanostructured lipid carriers (NLCs) containing first time using hybrid design experiments approach. The optimized...
Effects of chitosan coating on physical properties and pharmacokinetic behavior mitoxantrone liposomes Jie Zhuang1, Qineng Ping1, Yunmei Song2, Jianping Qi1, Zheng Cui31School Pharmacy, China Pharmaceutical University, Nanjing, China; 2School Pharmacy Medical Sciences, University South Australia, Adelaide, Australia; 3School Peking Beijing, ChinaAbstract: The objective this work was to evaluate the in vivo circulation (CH)-coated (MTO). Changes particle size zeta potential confirmed...
Pilot investigations have suggested that a novel, long-acting, injectable i.m. formulation of omeprazole (LA-OMEP) can induce acid suppression for up to 7 days following single injection.To investigate the pharmacodynamics and assess clinical efficacy LA-OMEP formulation.Part A comprised pharmacodynamic study. Part B consisted pilot trial.Part enrolled six adult Thoroughbred horses with percutaneous gastrotomy tubes. Intragastric pH was measured continuous 23-h periods (08.00-07.00 h) eight...
Targeting prostate cancer cells with hybrid elastin-like polypeptide/liposome nanoparticles Wei Zhang,1 Yunmei Song,1 Preethi Eldi,1 Xiuli Guo,2 John D Hayball,1,3 Sanjay Garg,1 Hugo Albrecht1 1Centre for Pharmaceutical Innovation and Development, Centre Drug Discovery Experimental Therapeutics Laboratory, Sansom Institute Health Research, School of Pharmacy Medical Sciences, University South Australia, Adelaide, SA, Australia; 2Department Pharmacology, Shandong University, Jinan, China;...
Enhancing cytosol delivery of exogenous antigens in antigen presenting cells can improve cross-presentation and CD8+ T cell-mediated immune response. The speed, which has great importance on the rate MHC class I molecules (MHC I) presentation pathway cytotoxic lymphocytes (CTLs) induction, not been well studied. We hypothesized that micelle-tailored vaccine with multiple cascaded lysosomal responsive capabilities could accelerate escape enhance cancer immunotherapy. To test our hypothesis,...
A novel drug delivery system preventing Glioblastoma multiforme (GBM) recurrence after resection surgery is imperatively required to overcome the mechanical limitation of current local and offer personalised treatment options for GBM patients. In this study, 3D printed biodegradable flexible porous scaffolds were developed via Fused Deposition Modelling (FDM) three-dimensional (3D) printing technology curcumin. The with various geometries containing 1, 3, 5, 7% (w/w) curcumin, respectively,...